ATE131073T1 - Konjugate zur knochenbilddarstellung und therapie von knochenkrebs. - Google Patents

Konjugate zur knochenbilddarstellung und therapie von knochenkrebs.

Info

Publication number
ATE131073T1
ATE131073T1 AT89907544T AT89907544T ATE131073T1 AT E131073 T1 ATE131073 T1 AT E131073T1 AT 89907544 T AT89907544 T AT 89907544T AT 89907544 T AT89907544 T AT 89907544T AT E131073 T1 ATE131073 T1 AT E131073T1
Authority
AT
Austria
Prior art keywords
bone
conjugates
therapy
imaging
chelate
Prior art date
Application number
AT89907544T
Other languages
English (en)
Inventor
Alan R Fritzberg
Jean-Luc E Vanderheyden
Sudhakar Kasina
Jeffrey N Fitzner
Original Assignee
Neorx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neorx Corp filed Critical Neorx Corp
Application granted granted Critical
Publication of ATE131073T1 publication Critical patent/ATE131073T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT89907544T 1988-06-10 1989-06-08 Konjugate zur knochenbilddarstellung und therapie von knochenkrebs. ATE131073T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20515688A 1988-06-10 1988-06-10
US07/207,686 US5089249A (en) 1988-06-10 1988-06-16 Conjugates for bone imaging and bone cancer therapy

Publications (1)

Publication Number Publication Date
ATE131073T1 true ATE131073T1 (de) 1995-12-15

Family

ID=26900166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89907544T ATE131073T1 (de) 1988-06-10 1989-06-08 Konjugate zur knochenbilddarstellung und therapie von knochenkrebs.

Country Status (8)

Country Link
US (1) US5089249A (de)
EP (1) EP0444038B1 (de)
JP (1) JPH03504976A (de)
AT (1) ATE131073T1 (de)
AU (1) AU3842989A (de)
CA (1) CA1338072C (de)
DE (1) DE68925034T2 (de)
WO (1) WO1989011877A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
DE68927479T2 (de) * 1988-05-02 1997-04-03 Phanos Tech Inc Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US5463080A (en) * 1992-08-27 1995-10-31 Bracco International B.V. 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
AU7261994A (en) * 1993-07-19 1995-02-20 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
US5858327A (en) * 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
US5574140A (en) * 1993-09-03 1996-11-12 Resolution Pharmaceutical Inc. Hydrazino-type N2 S2 chelators
JP4293632B2 (ja) * 1993-11-16 2009-07-08 ブラッコ インターナショナル ベースローテン フェンノートシャップ 固定化標識方法
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
BR9408590A (pt) * 1994-06-03 1997-08-26 Malinckrodt Medical Inc Agentes para imageamento ósseo rapidamente eliminaveis de fosfonato de tecnécio 99m
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6359111B1 (en) 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2001114792A (ja) * 1999-10-12 2001-04-24 Nihon Medi Physics Co Ltd ビスホスホン酸誘導体およびその放射性核種標識体
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
US7053188B2 (en) 2002-02-22 2006-05-30 Purdue Research Foundation Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
TW200505934A (en) * 2003-03-26 2005-02-16 Nihon Mediphysics Co Ltd Compound having affinity with calcified tissue
EP2041148A1 (de) * 2006-07-03 2009-04-01 Generics Ýuk¨Limited Neues verfahren zur herstellung von bisphosphonsäuren

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989730A (en) * 1972-06-15 1976-11-02 Research Corporation Bone-seeking technetium-99m complex
US4082840A (en) * 1972-09-13 1978-04-04 New England Nuclear Corporation Bone seeking technetium 99m complex
US4016249A (en) * 1972-09-13 1977-04-05 New England Nuclear Corporation Bone seeking technetium 99m complex
US3852414A (en) * 1972-09-13 1974-12-03 New England Nuclear Corp Bone seeking technetium 99m stannous phosphate complex
US4032625A (en) * 1973-06-11 1977-06-28 Research Corporation Bone-seeking technetium-99m complex
CA1027135A (en) * 1973-06-11 1978-02-28 Research Corporation Bone-seeking technetium-99m complex
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US3974268A (en) * 1975-05-30 1976-08-10 Research Corporation Bone-seeking technetium-99m imidodiphosphonate complex
US4017595A (en) * 1975-08-28 1977-04-12 Research Corporation Bone-seeking indium-113m or indium-111 organic phosphonate complexes
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4337240A (en) * 1978-04-20 1982-06-29 New England Nuclear Corporation Denatured albumin complexes for radioscintigraphic imaging and evaluation of reticuloendothelial systems
US4247534A (en) * 1978-07-31 1981-01-27 The Procter & Gamble Company Radiographic scanning agent
JPS5750928A (en) * 1980-09-13 1982-03-25 Nippon Mejifuijitsukusu Kk Diagnostic agent for scanning bone
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
GB8310438D0 (en) * 1983-04-18 1983-05-25 Amersham Int Plc Bone-seeking complexes of technetium-99m
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
DE3331159A1 (de) * 1983-08-30 1985-03-14 Hoechst Ag, 6230 Frankfurt N-(4-aminobenzoyl)-aminodicarbonsaeuren zur stabilisierung von technetium-99m-praeparaten, stabilisierte injektionspraeparate und verfahren zu ihrer herstellung
US4582700A (en) * 1983-09-01 1986-04-15 Mallinckrodt, Inc. Products and processes
US4560548A (en) * 1984-04-10 1985-12-24 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of bis(aminoalkyl)piperazine
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
EP0176288B1 (de) * 1984-09-21 1990-05-09 The Dow Chemical Company Aminocarbonsäurekomplexe zur Behandlung von Knochentumoren
US4617184A (en) * 1984-11-29 1986-10-14 Tsolis Alexandros K 99m Tc-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane complex for skeleton scanning
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US4830847A (en) * 1985-06-28 1989-05-16 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
GB8521380D0 (en) * 1985-08-28 1985-10-02 Amersham Int Plc Bone-seeking complexes of technetium-99m
GB8615916D0 (en) * 1986-06-30 1986-08-06 Amersham Int Plc Bone-seeking complexes of technetium-99m
EP0284071B1 (de) * 1987-03-26 1994-06-08 Neorx Corporation Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie

Also Published As

Publication number Publication date
EP0444038B1 (de) 1995-12-06
CA1338072C (en) 1996-02-20
JPH03504976A (ja) 1991-10-31
AU3842989A (en) 1990-01-05
US5089249A (en) 1992-02-18
DE68925034D1 (de) 1996-01-18
WO1989011877A3 (en) 1990-03-08
EP0444038A1 (de) 1991-09-04
DE68925034T2 (de) 1996-04-25
WO1989011877A2 (en) 1989-12-14

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