DK0710228T3 - Hydraziner med N3S-konfiguration som radionuclidchelatorer - Google Patents
Hydraziner med N3S-konfiguration som radionuclidchelatorerInfo
- Publication number
- DK0710228T3 DK0710228T3 DK94922812T DK94922812T DK0710228T3 DK 0710228 T3 DK0710228 T3 DK 0710228T3 DK 94922812 T DK94922812 T DK 94922812T DK 94922812 T DK94922812 T DK 94922812T DK 0710228 T3 DK0710228 T3 DK 0710228T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrazines
- configuration
- radionuclide chelators
- radionuclide
- chelators
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title 1
- 150000002429 hydrazines Chemical class 0.000 title 1
- 230000008685 targeting Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Transmitters (AREA)
- Transceivers (AREA)
- Peptides Or Proteins (AREA)
- Lock And Its Accessories (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9291193A | 1993-07-19 | 1993-07-19 | |
| PCT/CA1994/000395 WO1995003280A1 (en) | 1993-07-19 | 1994-07-18 | Hydrazino-type radionuclide chelators having an n3s configuration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0710228T3 true DK0710228T3 (da) | 1998-09-21 |
Family
ID=22235766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94922812T DK0710228T3 (da) | 1993-07-19 | 1994-07-18 | Hydraziner med N3S-konfiguration som radionuclidchelatorer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5659041A (da) |
| EP (1) | EP0710228B1 (da) |
| JP (1) | JPH09500140A (da) |
| AT (1) | ATE162524T1 (da) |
| AU (1) | AU7261994A (da) |
| CA (1) | CA2167167A1 (da) |
| DE (1) | DE69408145T2 (da) |
| DK (1) | DK0710228T3 (da) |
| ES (1) | ES2114209T3 (da) |
| GR (1) | GR3026658T3 (da) |
| WO (1) | WO1995003280A1 (da) |
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| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
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| DE19536781A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
| DE19536785A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope |
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| WO1999012579A1 (en) * | 1997-09-08 | 1999-03-18 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
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| US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
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| US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
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| ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
| AU2225192A (en) * | 1991-05-01 | 1992-12-21 | Curators Of The University Of Missouri, The | Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical |
| WO1992019274A1 (en) * | 1991-05-08 | 1992-11-12 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| AU657770B2 (en) * | 1991-06-03 | 1995-03-23 | Mallinckrodt Medical, Inc. | Radiolabelled somatostatin derivatives, their preparation and use |
| AU670029B2 (en) * | 1991-08-05 | 1996-07-04 | Mallinckrodt Medical, Inc. | Heavy metal clusters for use as imaging agents |
-
1994
- 1994-07-18 AU AU72619/94A patent/AU7261994A/en not_active Abandoned
- 1994-07-18 AT AT94922812T patent/ATE162524T1/de not_active IP Right Cessation
- 1994-07-18 WO PCT/CA1994/000395 patent/WO1995003280A1/en not_active Ceased
- 1994-07-18 EP EP94922812A patent/EP0710228B1/en not_active Expired - Lifetime
- 1994-07-18 ES ES94922812T patent/ES2114209T3/es not_active Expired - Lifetime
- 1994-07-18 CA CA002167167A patent/CA2167167A1/en not_active Abandoned
- 1994-07-18 DE DE69408145T patent/DE69408145T2/de not_active Expired - Fee Related
- 1994-07-18 JP JP7504829A patent/JPH09500140A/ja active Pending
- 1994-07-18 DK DK94922812T patent/DK0710228T3/da active
- 1994-09-02 US US08/299,636 patent/US5659041A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 GR GR980400861T patent/GR3026658T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69408145T2 (de) | 1998-09-03 |
| DE69408145D1 (de) | 1998-02-26 |
| EP0710228B1 (en) | 1998-01-21 |
| ES2114209T3 (es) | 1998-05-16 |
| AU7261994A (en) | 1995-02-20 |
| US5659041A (en) | 1997-08-19 |
| JPH09500140A (ja) | 1997-01-07 |
| EP0710228A1 (en) | 1996-05-08 |
| WO1995003280A1 (en) | 1995-02-02 |
| GR3026658T3 (en) | 1998-07-31 |
| CA2167167A1 (en) | 1995-02-02 |
| ATE162524T1 (de) | 1998-02-15 |
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