ATE131385T1 - Platin-polymer-komplexe und deren verwendung als antitumormittel - Google Patents

Platin-polymer-komplexe und deren verwendung als antitumormittel

Info

Publication number
ATE131385T1
ATE131385T1 AT89906967T AT89906967T ATE131385T1 AT E131385 T1 ATE131385 T1 AT E131385T1 AT 89906967 T AT89906967 T AT 89906967T AT 89906967 T AT89906967 T AT 89906967T AT E131385 T1 ATE131385 T1 AT E131385T1
Authority
AT
Austria
Prior art keywords
platinum
complexes
amine
biodegradable
biostable
Prior art date
Application number
AT89906967T
Other languages
English (en)
Inventor
Devinder S Dr Gill
Peter J Andrulis Jr
Original Assignee
Andrulis Res Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrulis Res Corp filed Critical Andrulis Res Corp
Application granted granted Critical
Publication of ATE131385T1 publication Critical patent/ATE131385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT89906967T 1988-05-11 1989-05-11 Platin-polymer-komplexe und deren verwendung als antitumormittel ATE131385T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/192,451 US4931553A (en) 1988-05-11 1988-05-11 Platinum-polymer complexes and their use as antitumor agents

Publications (1)

Publication Number Publication Date
ATE131385T1 true ATE131385T1 (de) 1995-12-15

Family

ID=22709709

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89906967T ATE131385T1 (de) 1988-05-11 1989-05-11 Platin-polymer-komplexe und deren verwendung als antitumormittel

Country Status (11)

Country Link
US (1) US4931553A (de)
EP (1) EP0419535B1 (de)
JP (1) JP2787241B2 (de)
AT (1) ATE131385T1 (de)
AU (1) AU620111B2 (de)
CA (1) CA1338823C (de)
DE (1) DE68925120T2 (de)
IE (1) IE71226B1 (de)
IL (1) IL90259A0 (de)
WO (1) WO1989010928A1 (de)
ZA (1) ZA893500B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5118499A (en) * 1991-06-19 1992-06-02 Spyros Theodoropulos Quinoline polymers, their chelates and process of preparation and use
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
KR0164460B1 (ko) * 1995-10-02 1999-03-20 김은영 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
EP0904066A4 (de) * 1996-05-03 2002-04-24 Roger S Cubicciotti Prodrug-zusammensetzungen und verfahren zur arzneistoffverabreichung unter verwendung synthetischer rezeptoren
US5965118A (en) * 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
DE19723155B4 (de) * 1997-06-03 2006-03-23 Gradl, Toni, Dr. Verwendung eines Eisensalzes der Alginsäure zur Therapie rheumatischer Erkrankungen
US6585956B2 (en) * 1997-07-07 2003-07-01 The Dow Chemical Company Dendritic-platinate drug delivery system
RU2128042C1 (ru) * 1998-05-27 1999-03-27 Онкологический научный центр РАМН Противоопухолевое средство
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
FR2797786B1 (fr) * 1999-08-27 2001-10-05 Commissariat Energie Atomique Procede et installation d'elimination des cations metalliques d'un liquide par des resines de polyazacycloalcanes greffes sur un support
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
CA2548457C (en) * 2003-12-10 2010-08-24 Toudai Tlo, Ltd. Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same
JP5201572B2 (ja) * 2005-06-09 2013-06-05 ナノキャリア株式会社 白金錯体のポリマー化配位化合物の製造方法
WO2007006019A1 (en) * 2005-07-06 2007-01-11 University Of South Florida Materials and methods for screening, diagnosis and prognosis of conditions associated with stat protein expression
BRPI1008869A2 (pt) 2009-02-04 2016-03-15 Brigham & Womens Hospital nanopartícula, composto, composição farmacêutica, método para tratar câncer ou metástase, e, método de liberação prolongada de um composto de platina
EP2740737B1 (de) * 2012-12-05 2015-09-16 Heraeus Deutschland GmbH & Co. KG 1,2-Cyclohexandiaminplatin(II) bis-(4-methylbenzolsulfonat) und dessen Hydrate
CZ309355B6 (cs) * 2018-09-10 2022-09-28 Univerzita Tomáše Bati ve Zlíně Způsob přípravy konjugátů s řízenou rychlostí uvolňování léčiva s nosiči protinádorového léčiva na bázi selektivně oxidovaných polysacharidů
CN114209848B (zh) * 2021-12-27 2024-02-23 中国科学技术大学 一种具有运输siRNA功能的铂肽共聚物的制备方法及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
US4151185A (en) * 1977-05-02 1979-04-24 Research Corporation Complex or salt of a platinum (II) compound and a nitrogen containing polymer
US4137248A (en) * 1977-08-29 1979-01-30 The United States Of America As Represented By The Department Of Health, Education And Welfare Compound, 4-carboxyphthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof
JPS5829957B2 (ja) * 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
US4283342A (en) * 1980-01-31 1981-08-11 University Of Delaware Anticancer agents and methods of manufacture
JPS5921697A (ja) * 1982-06-24 1984-02-03 Yoshinori Kitani 新規な白金錯体
US4584392A (en) * 1982-11-10 1986-04-22 Inco Alloys International, Inc. Platinum and palladium complexes
JPS59112995A (ja) * 1982-12-21 1984-06-29 Shionogi & Co Ltd 新規グリコ−ル酸白金錯体
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
US4720504A (en) * 1983-05-10 1988-01-19 Andrulis Research Corporation Use of bis-platinum complexes as antitumor agents
JPS6034982A (ja) * 1983-08-05 1985-02-22 Yoshinori Kitani １，２−ジアミノシクロヘキサン白金（２）錯体
US4673754A (en) * 1983-10-14 1987-06-16 Inco Alloys International, Inc. Platinum and palladium complexes
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
CS253069B1 (en) * 1984-11-09 1987-10-15 Jaroslav Drobnik Macromolecular anticarcinogenetic remedy containing platinum and method of its production
IL73972A0 (en) * 1984-12-31 1985-03-31 Yeda Res & Dev Agents based on platinum compounds
JPH0665648B2 (ja) * 1985-09-25 1994-08-24 塩野義製薬株式会社 白金系抗癌物質の安定な凍結真空乾燥製剤
US4680308A (en) * 1985-12-26 1987-07-14 Andrulis Research Corporation Stable soluble 1,2-diaminocyclohexane platinum complexes
US4793986A (en) * 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
ATE129254T1 (de) * 1987-03-19 1995-11-15 Arthropharm Pty Ltd Antientzündungsmittel und zusammensetzungen.
EP0307827A3 (de) * 1987-09-15 1989-12-27 Kuraray Co., Ltd. Makromolekulare Komplexe, ihre Herstellung und Verwendung in der Medizin

Also Published As

Publication number Publication date
US4931553A (en) 1990-06-05
ZA893500B (en) 1990-01-31
JP2787241B2 (ja) 1998-08-13
JPH03504859A (ja) 1991-10-24
IE71226B1 (en) 1997-02-12
AU620111B2 (en) 1992-02-13
AU3751389A (en) 1989-11-29
WO1989010928A1 (en) 1989-11-16
DE68925120T2 (de) 1996-07-04
CA1338823C (en) 1996-12-31
EP0419535B1 (de) 1995-12-13
IL90259A0 (en) 1989-12-15
EP0419535A1 (de) 1991-04-03
DE68925120D1 (de) 1996-01-25
EP0419535A4 (en) 1993-02-24
IE891537L (en) 1989-11-11

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