ATE133962T1 - Proteine mit antikoagulierenden eigenschaften - Google Patents

Proteine mit antikoagulierenden eigenschaften

Info

Publication number
ATE133962T1
ATE133962T1 AT90309834T AT90309834T ATE133962T1 AT E133962 T1 ATE133962 T1 AT E133962T1 AT 90309834 T AT90309834 T AT 90309834T AT 90309834 T AT90309834 T AT 90309834T AT E133962 T1 ATE133962 T1 AT E133962T1
Authority
AT
Austria
Prior art keywords
proteins
inhibitors
factor
anticoagulation properties
inhibit
Prior art date
Application number
AT90309834T
Other languages
English (en)
Inventor
George P Vlasuk
Lloyd H Waxman
Victor M Garsky
Michael P Neeper
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE133962T1 publication Critical patent/ATE133962T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90309834T 1989-09-07 1990-09-07 Proteine mit antikoagulierenden eigenschaften ATE133962T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40403389A 1989-09-07 1989-09-07
US49830790A 1990-03-23 1990-03-23
US56516490A 1990-08-13 1990-08-13

Publications (1)

Publication Number Publication Date
ATE133962T1 true ATE133962T1 (de) 1996-02-15

Family

ID=27410566

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90309834T ATE133962T1 (de) 1989-09-07 1990-09-07 Proteine mit antikoagulierenden eigenschaften

Country Status (8)

Country Link
EP (1) EP0419099B1 (de)
JP (1) JP3034926B2 (de)
AT (1) ATE133962T1 (de)
AU (1) AU639257B2 (de)
CA (1) CA2024697A1 (de)
DE (1) DE69025247T2 (de)
DK (1) DK0419099T3 (de)
IE (1) IE70759B1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
US5278144A (en) * 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
DE4136087A1 (de) * 1991-10-31 1993-05-06 Basf Ag, 6700 Ludwigshafen, De Neues thrombininhibitorisches protein aus zecken
US5321010A (en) * 1991-12-10 1994-06-14 Merck & Co., Inc. Proteins for inhibiting adhesion of platelets to collagen
WO1994012204A1 (en) * 1992-12-01 1994-06-09 Merck & Co., Inc. Anticoagulant proteins
WO1995011691A1 (en) * 1993-10-29 1995-05-04 Merck & Co., Inc. Antithrombotic proteins
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
EP0788546B9 (de) * 1994-10-18 2007-06-13 Dendreon Corporation Aus nematoden extrahierte serinprotease-inhibitoren und die koagulation hemmende proteine
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
US6245741B1 (en) 1998-05-19 2001-06-12 Washington University Protein Z-dependent protease inhibitor
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
CA2623565A1 (en) 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
CN112552382A (zh) * 2020-01-22 2021-03-26 天津科技大学 一种信号肽突变体及其用途

Also Published As

Publication number Publication date
DE69025247D1 (de) 1996-03-21
IE903245A1 (en) 1991-03-13
JPH03178997A (ja) 1991-08-02
EP0419099A1 (de) 1991-03-27
AU6224790A (en) 1991-03-14
DE69025247T2 (de) 1996-09-12
CA2024697A1 (en) 1991-03-08
DK0419099T3 (da) 1996-03-11
EP0419099B1 (de) 1996-02-07
AU639257B2 (en) 1993-07-22
JP3034926B2 (ja) 2000-04-17
IE70759B1 (en) 1996-12-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee