ATE134996T1 - Heterozyklische acetylenische amine mit wirkung auf das zentrale nervensystem - Google Patents
Heterozyklische acetylenische amine mit wirkung auf das zentrale nervensystemInfo
- Publication number
- ATE134996T1 ATE134996T1 AT89910266T AT89910266T ATE134996T1 AT E134996 T1 ATE134996 T1 AT E134996T1 AT 89910266 T AT89910266 T AT 89910266T AT 89910266 T AT89910266 T AT 89910266T AT E134996 T1 ATE134996 T1 AT E134996T1
- Authority
- AT
- Austria
- Prior art keywords
- disorders
- nervous system
- central nervous
- acetyleneric
- heterocyclic
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 201000006347 Intellectual Disability Diseases 0.000 abstract 1
- 208000036626 Mental retardation Diseases 0.000 abstract 1
- 208000019430 Motor disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000000064 cholinergic agonist Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000036997 mental performance Effects 0.000 abstract 1
- 210000001002 parasympathetic nervous system Anatomy 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26367288A | 1988-10-27 | 1988-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE134996T1 true ATE134996T1 (de) | 1996-03-15 |
Family
ID=23002777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89910266T ATE134996T1 (de) | 1988-10-27 | 1989-08-25 | Heterozyklische acetylenische amine mit wirkung auf das zentrale nervensystem |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5137905A (de) |
| EP (2) | EP0440670B1 (de) |
| JP (1) | JPH04501850A (de) |
| KR (1) | KR900701758A (de) |
| AT (1) | ATE134996T1 (de) |
| AU (1) | AU636577B2 (de) |
| DE (1) | DE68925906T2 (de) |
| DK (1) | DK69991A (de) |
| WO (1) | WO1990004588A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149705A (en) * | 1987-03-13 | 1992-09-22 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity |
| US5550257A (en) * | 1991-04-24 | 1996-08-27 | American Cyanamid Company | Substituted oxotremorine derivatives |
| BR9206371A (pt) * | 1991-08-14 | 1995-10-17 | Procter & Gamble Pharma | Novas uréias cíclicas utilzáveis como agentes antirrítmicos e antifibrilatórios |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| USRE37781E1 (en) | 1991-10-11 | 2002-07-02 | Dupont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| DE4414569A1 (de) * | 1994-04-27 | 1995-11-02 | Bayer Ag | Verwendung von substituierten Aminen zur Behandlung von Hirnleistungsstörungen |
| ZA966885B (en) * | 1995-08-22 | 1998-02-16 | Du Pont Merck Pharma | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors. |
| EP0891352A4 (de) * | 1996-04-03 | 2001-08-16 | Merck & Co Inc | Inhibitoren der farnesyl-protein transferase |
| EP0818439B1 (de) * | 1996-07-02 | 1999-10-13 | Nisshin Flour Milling Co., Ltd. | Imid derivate |
| US6313110B1 (en) | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
| JP2007509898A (ja) | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1218455B (de) * | 1964-01-30 | 1966-06-08 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung von basisch substituierten cyclischen Harnstoffen und ihren Salzen |
| GB1245743A (en) * | 1967-11-09 | 1971-09-08 | Astra Ab | Alkynyl lactams |
| US4011238A (en) * | 1972-07-26 | 1977-03-08 | Gruppo Lepetit S.P.A. | 2-imidazolidione derivatives |
| WO1990001026A1 (en) * | 1988-07-25 | 1990-02-08 | The Upjohn Company | Acetylenic imidazoles having central nervous system activity |
| US5001142A (en) * | 1989-07-19 | 1991-03-19 | American Cyanamid Company | 1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives |
-
1989
- 1989-08-22 US US07/675,891 patent/US5137905A/en not_active Expired - Fee Related
- 1989-08-25 JP JP1509349A patent/JPH04501850A/ja active Pending
- 1989-08-25 WO PCT/US1989/003596 patent/WO1990004588A1/en not_active Ceased
- 1989-08-25 AT AT89910266T patent/ATE134996T1/de active
- 1989-08-25 KR KR1019900701364A patent/KR900701758A/ko not_active Ceased
- 1989-08-25 DE DE68925906T patent/DE68925906T2/de not_active Expired - Fee Related
- 1989-08-25 EP EP89910266A patent/EP0440670B1/de not_active Expired - Lifetime
- 1989-08-25 EP EP94101367A patent/EP0605393A1/de not_active Withdrawn
- 1989-08-25 AU AU42109/89A patent/AU636577B2/en not_active Ceased
-
1991
- 1991-04-18 DK DK069991A patent/DK69991A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68925906D1 (de) | 1996-04-11 |
| DE68925906T2 (de) | 1996-08-29 |
| US5137905A (en) | 1992-08-11 |
| EP0440670B1 (de) | 1996-03-06 |
| DK69991D0 (da) | 1991-04-18 |
| EP0440670A1 (de) | 1991-08-14 |
| AU636577B2 (en) | 1993-05-06 |
| DK69991A (da) | 1991-04-18 |
| AU4210989A (en) | 1990-05-14 |
| EP0605393A1 (de) | 1994-07-06 |
| KR900701758A (ko) | 1990-12-04 |
| JPH04501850A (ja) | 1992-04-02 |
| WO1990004588A1 (en) | 1990-05-03 |
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