ATE137242T1 - Kovalente-ther lipidnukleosid-konjugate - Google Patents
Kovalente-ther lipidnukleosid-konjugateInfo
- Publication number
- ATE137242T1 ATE137242T1 AT91912194T AT91912194T ATE137242T1 AT E137242 T1 ATE137242 T1 AT E137242T1 AT 91912194 T AT91912194 T AT 91912194T AT 91912194 T AT91912194 T AT 91912194T AT E137242 T1 ATE137242 T1 AT E137242T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- lipidenucleoside
- ther
- covalent
- deoxythymidine
- Prior art date
Links
- -1 Ether lipid nucleoside Chemical class 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53900190A | 1990-06-15 | 1990-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE137242T1 true ATE137242T1 (de) | 1996-05-15 |
Family
ID=24149332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91912194T ATE137242T1 (de) | 1990-06-15 | 1991-06-14 | Kovalente-ther lipidnukleosid-konjugate |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0533825B1 (de) |
| JP (1) | JPH05507929A (de) |
| AT (1) | ATE137242T1 (de) |
| AU (1) | AU660417B2 (de) |
| CA (1) | CA2085354C (de) |
| DE (1) | DE69119074T2 (de) |
| WO (1) | WO1991019726A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
| US5817638A (en) * | 1988-07-07 | 1998-10-06 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
| US6252060B1 (en) | 1988-07-07 | 2001-06-26 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
| US5411947A (en) * | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5543389A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5827819A (en) | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
| AU668873B2 (en) * | 1991-07-12 | 1996-05-23 | Chimerix, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
| US5484911A (en) * | 1993-04-01 | 1996-01-16 | Health Research, Inc. | Nucleoside 5'-diphosphate conjugates of ether lipids |
| KR0125779B1 (ko) * | 1993-12-04 | 1997-12-19 | 김승호 | 뉴클레오시드 화합물 및 이의 제조방법 |
| JP4259611B2 (ja) | 1994-08-29 | 2009-04-30 | ウェイク フォレスト ユニバーシティ | ウィルス感染を治療するための脂質アナログ |
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| US20020106363A1 (en) * | 1994-11-12 | 2002-08-08 | Dieter Herrmann | Lipid cleavage enzyme |
| DE19505168A1 (de) * | 1995-02-16 | 1996-08-22 | Boehringer Mannheim Gmbh | Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel |
| JPH11514009A (ja) * | 1996-07-23 | 1999-11-30 | オレゴン ヘルス サイエンスィズ ユニヴァースティ | 軟膏において用いるための、生物学的に活性の成分との共有結合極性脂質結合体 |
| DE19855963A1 (de) * | 1998-12-04 | 2000-06-08 | Herbert Schott | Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| IT1306129B1 (it) * | 1999-04-13 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
| US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| US6670341B1 (en) * | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
| US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
| KR100871648B1 (ko) | 2001-08-31 | 2008-12-03 | 톰슨 라이센싱 | 조건부 액세스 시스템을 구현하는 방법, 컨텐트를 전송하는 방법 및 그 장치 및 컨텐트를 수신하고 처리하는 방법 및 그 장치 |
| ES2401285T3 (es) * | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
| WO2007130783A2 (en) | 2006-05-03 | 2007-11-15 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
| WO2008118879A2 (en) * | 2007-03-23 | 2008-10-02 | Ardea Biosciences, Inc. | Antiviral compositions comprising 2 compounds |
| SG10201800188SA (en) | 2013-03-15 | 2018-02-27 | Univ California | Acyclic nucleoside phosphonate diesters |
| CN111808136B (zh) | 2014-09-15 | 2024-06-11 | 加利福尼亚大学董事会 | 核苷酸类似物 |
| EP3350191B9 (de) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nukleotidanaloga |
| KR20250052378A (ko) | 2022-07-21 | 2025-04-18 | 안티바 바이오사이언시즈, 인크. | Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291024A (en) * | 1978-04-10 | 1981-09-22 | Turcotte Joseph G | Cytotoxic liponucleotide analogs |
| US4622392A (en) * | 1984-06-21 | 1986-11-11 | Health Research Inc. (Roswell Park Division) | Thiophospholipid conjugates of antitumor agents |
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| GB2175588B (en) * | 1985-04-15 | 1988-08-10 | Toyo Jozo Kk | Nucleoside-phospholipid conjugates |
| DE3778626D1 (de) * | 1986-09-27 | 1992-06-04 | Toyo Jozo Kk | Nukleosid-phospholipid-konjugat. |
-
1991
- 1991-06-14 WO PCT/US1991/004289 patent/WO1991019726A1/en not_active Ceased
- 1991-06-14 DE DE69119074T patent/DE69119074T2/de not_active Expired - Fee Related
- 1991-06-14 JP JP91511531A patent/JPH05507929A/ja active Pending
- 1991-06-14 AU AU80597/91A patent/AU660417B2/en not_active Ceased
- 1991-06-14 CA CA002085354A patent/CA2085354C/en not_active Expired - Lifetime
- 1991-06-14 AT AT91912194T patent/ATE137242T1/de not_active IP Right Cessation
- 1991-06-14 EP EP91912194A patent/EP0533825B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69119074D1 (de) | 1996-05-30 |
| EP0533825B1 (de) | 1996-04-24 |
| JPH05507929A (ja) | 1993-11-11 |
| WO1991019726A1 (en) | 1991-12-26 |
| AU8059791A (en) | 1992-01-07 |
| CA2085354A1 (en) | 1991-12-16 |
| EP0533825A4 (en) | 1993-06-02 |
| AU660417B2 (en) | 1995-06-29 |
| DE69119074T2 (de) | 1996-12-12 |
| CA2085354C (en) | 2002-08-27 |
| EP0533825A1 (de) | 1993-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE137242T1 (de) | Kovalente-ther lipidnukleosid-konjugate | |
| YU78291A (sh) | 1,3-oksatiolanski nukleozidni analozi | |
| ATE75142T1 (de) | Dhp-manteltablette. | |
| FI863652A0 (fi) | 7-isopropoxiisflavoninklusionskomplex bildat med cyklodextrin och ett foerfarande foer dess framstaellning. | |
| FI20001231A7 (fi) | 2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina | |
| DK502888D0 (da) | Anvendelse af azithromycin og derivater deraf til fremstilling af antiprotozoale laegemidler | |
| MX9102353A (es) | N,o-sulfados de heparosanos, su procedimiento de preparacion y las composiciones farmaceuticas que contienen. | |
| DK183386A (da) | Sucralfatsuspension | |
| FR2601675B1 (fr) | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent | |
| ES2138969T3 (es) | Combinacion de nucleosidos antivirales. | |
| ES2139574T3 (es) | Nuevos gases propulsores y su uso en preparaciones medicas. | |
| IT1226825B (it) | Derivati 4' fosfato di glucosidi della epipodofillotossina e relative composizioni farmaceutiche. | |
| DK393187A (da) | Laegemiddel med antitumorvirkning | |
| FI830100L (fi) | Nya 6-substituerade s-triazolo /3,4-a/ ftalazinderivat | |
| MX9303711A (es) | Nucleosidos de pirimida sustituida que tienen actividad anti-tumoral y anti-viral y composicion farmaceutica que los contiene. | |
| MX9203320A (es) | Composicion antialergica que contiene compuestos biciclicos switterionicos. | |
| TR200102313T2 (tr) | Antiviral maddeler olarak (1R, SíS)-4-(6-amino-9H-purin-9-il)-2-siklopenten-1-metanoln mono-, di ve tri-fosfat esterleri ve fosforamidatlarì | |
| FR2679906B1 (fr) | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| DE3887014D1 (de) | Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen. | |
| FI891283A0 (fi) | Ifosfamid-mesna-lyofilisat och foerfarande foer dess framstaellning. | |
| SE503436C2 (sv) | Pyroglutamidderivat | |
| SE8205905D0 (sv) | 1,4-dihydropyridinforeningar | |
| SE8102456L (sv) | Farmaceutisk komposition for oral administering och innehallande cytidindifosfokolin | |
| KR880007080A (ko) | 제약학적 생성물 | |
| IT1232819B (it) | Impiego di sorgenti di nucleobasi per stimolare la funzione immunitaria, relativo procedimento e composizioni farmaceutiche contenenti una tale sorgente di nucleobasi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |