ATE138661T1 - Hexacyclische verbindungen - Google Patents

Hexacyclische verbindungen

Info

Publication number
ATE138661T1
ATE138661T1 AT92100449T AT92100449T ATE138661T1 AT E138661 T1 ATE138661 T1 AT E138661T1 AT 92100449 T AT92100449 T AT 92100449T AT 92100449 T AT92100449 T AT 92100449T AT E138661 T1 ATE138661 T1 AT E138661T1
Authority
AT
Austria
Prior art keywords
compound
antitumour
hexacyclic compounds
abundantly
camptothecin
Prior art date
Application number
AT92100449T
Other languages
English (en)
Inventor
Hirofumi Terasawa
Akio Ejima
Satoru Ohsuki
Kouichi Uoto
Original Assignee
Daiichi Seiyaku Co
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Yakult Honsha Kk filed Critical Daiichi Seiyaku Co
Application granted granted Critical
Publication of ATE138661T1 publication Critical patent/ATE138661T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT92100449T 1991-01-16 1992-01-13 Hexacyclische verbindungen ATE138661T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1581291 1991-01-16

Publications (1)

Publication Number Publication Date
ATE138661T1 true ATE138661T1 (de) 1996-06-15

Family

ID=11899258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92100449T ATE138661T1 (de) 1991-01-16 1992-01-13 Hexacyclische verbindungen

Country Status (14)

Country Link
EP (1) EP0495432B1 (de)
JP (1) JP3008226B2 (de)
KR (1) KR100191193B1 (de)
AT (1) ATE138661T1 (de)
AU (1) AU640549B2 (de)
CA (1) CA2059305C (de)
DE (1) DE69211023T2 (de)
DK (1) DK0495432T3 (de)
ES (1) ES2090366T3 (de)
FI (1) FI103047B1 (de)
GR (1) GR3020395T3 (de)
IE (1) IE920079A1 (de)
NO (1) NO180448C (de)
RU (1) RU2071476C1 (de)

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FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
IN189180B (de) 1997-07-09 2003-01-04 Chong Kun Dang Corp
FR2772763B1 (fr) * 1997-12-24 2004-01-23 Sod Conseils Rech Applic Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
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JPWO2018110515A1 (ja) 2016-12-12 2019-10-24 第一三共株式会社 抗体−薬物コンジュゲートと免疫チェックポイント阻害剤の組み合わせ
SG11201906554RA (en) 2017-01-17 2019-08-27 Daiichi Sankyo Co Ltd Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate
US12667557B2 (en) 2017-02-28 2026-06-30 Daiichi Sankyo Company, Limited Method for treating EGFR-TKI-resistant non-small cell lung cancer by administration of anti-HER3 antibody-drug conjugate
TWI926682B (zh) 2017-05-15 2026-05-21 日商第一三共股份有限公司 抗體－藥物結合物之製造方法
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EP3794042B1 (de) 2018-05-18 2024-03-27 Daiichi Sankyo Co., Ltd. Conjugue agent cytotoxique et anticorps anti-muc1-exatecan
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TW202140076A (zh) * 2020-01-22 2021-11-01 英商梅迪繆思有限公司 化合物及其軛合物
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WO2022171115A1 (zh) * 2021-02-09 2022-08-18 微境生物医药科技(上海)有限公司 用于adc制备的喜树碱衍生物
WO2022262789A1 (zh) * 2021-06-17 2022-12-22 明慧医药（杭州）有限公司 一种抗肿瘤化合物及其应用
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EP4389732A4 (de) * 2021-08-17 2025-08-27 Jiangsu Mabwell Health Pharmaceutical R&D Co Ltd Verfahren zur synthese von 5,8-diamino-3,4-dihydro-2h-1-naphthalenon und dabei verwendete zwischenverbindung
CN115724758B (zh) * 2021-08-24 2024-12-27 杭州中美华东制药有限公司 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法
US20250059143A1 (en) * 2021-10-26 2025-02-20 Shanghai Best-Link Bioscience, Llc Camptothecin derivative intermediate, and preparation method therefor and use thereof
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Publication number Priority date Publication date Assignee Title
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives

Also Published As

Publication number Publication date
CA2059305C (en) 2001-07-31
KR100191193B1 (ko) 1999-06-15
NO180448B (no) 1997-01-13
AU1018592A (en) 1992-07-23
NO920201L (no) 1992-07-17
DE69211023T2 (de) 1997-01-09
FI920194A7 (fi) 1992-07-17
IE920079A1 (en) 1992-07-29
KR920014816A (ko) 1992-08-25
CA2059305A1 (en) 1992-07-17
AU640549B2 (en) 1993-08-26
GR3020395T3 (en) 1996-09-30
NO180448C (no) 1997-04-23
FI103047B (fi) 1999-04-15
NO920201D0 (no) 1992-01-15
DK0495432T3 (da) 1996-10-21
JP3008226B2 (ja) 2000-02-14
HK1001561A1 (en) 1998-06-26
EP0495432A1 (de) 1992-07-22
FI920194A0 (fi) 1992-01-16
JPH0559061A (ja) 1993-03-09
DE69211023D1 (de) 1996-07-04
ES2090366T3 (es) 1996-10-16
RU2071476C1 (ru) 1997-01-10
EP0495432B1 (de) 1996-05-29
FI103047B1 (fi) 1999-04-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee