ES2090366T3 - Compuestos hexaciclicos. - Google Patents

Compuestos hexaciclicos.

Info

Publication number
ES2090366T3
ES2090366T3 ES92100449T ES92100449T ES2090366T3 ES 2090366 T3 ES2090366 T3 ES 2090366T3 ES 92100449 T ES92100449 T ES 92100449T ES 92100449 T ES92100449 T ES 92100449T ES 2090366 T3 ES2090366 T3 ES 2090366T3
Authority
ES
Spain
Prior art keywords
compound
hexaciclic
compounds
aminoocetone
camptothecine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92100449T
Other languages
English (en)
Inventor
Hirofumi Terasawa
Akio Ejima
Satoru Ohsuki
Kouichi Uoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Yakult Honsha Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd, Yakult Honsha Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2090366T3 publication Critical patent/ES2090366T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN NUEVO COMPUESTO HEXA-CICLICO, UN DERIVADO DE CAMPTOTHECINA, DE FORMULA GENERAL: ESTE COMPUESTO ESTA PREPARADO A PARTIR DE UN COMPUESTO AMINOCETONA Y UN COMPUESTO PIRANOINDOLIZINA MEDIANTE LA REACCION DE CIERRE DEL ANILLO DE CONDENSACION. ES ALTAMENTE SOLUBLE EN AGUA Y TIENE UNA EXCELENTE ACTIVIDAD ANTITUMORAL Y UN ALTO GRADO DE SEGURIDAD, Y PUEDE SER APLICADO COMO MEDICINA ANTITUMOR PARA CURAR TUMORES DE VARIOS TIPOS.
ES92100449T 1991-01-16 1992-01-13 Compuestos hexaciclicos. Expired - Lifetime ES2090366T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1581291 1991-01-16

Publications (1)

Publication Number Publication Date
ES2090366T3 true ES2090366T3 (es) 1996-10-16

Family

ID=11899258

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92100449T Expired - Lifetime ES2090366T3 (es) 1991-01-16 1992-01-13 Compuestos hexaciclicos.

Country Status (14)

Country Link
EP (1) EP0495432B1 (es)
JP (1) JP3008226B2 (es)
KR (1) KR100191193B1 (es)
AT (1) ATE138661T1 (es)
AU (1) AU640549B2 (es)
CA (1) CA2059305C (es)
DE (1) DE69211023T2 (es)
DK (1) DK0495432T3 (es)
ES (1) ES2090366T3 (es)
FI (1) FI103047B1 (es)
GR (1) GR3020395T3 (es)
IE (1) IE920079A1 (es)
NO (1) NO180448C (es)
RU (1) RU2071476C1 (es)

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FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
FR2757515B1 (fr) * 1996-12-20 2000-05-05 Sod Conseils Rech Applic Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
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FR2790474B1 (fr) * 1999-03-05 2001-04-06 Synthelabo Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
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CL2011000716A1 (es) 2010-03-31 2012-04-20 Gilead Pharmasset Llc Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
WO2014057687A1 (ja) 2012-10-11 2014-04-17 第一三共株式会社 抗体－薬物コンジュゲート
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
PT3088419T (pt) 2013-12-25 2019-01-11 Daiichi Sankyo Co Ltd Conjugado de anticorpo anti-trop2-fármaco
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CN111228511B (zh) 2014-04-10 2024-06-18 第一三共株式会社 抗her3抗体-药物偶联物
CN116059395A (zh) 2015-06-29 2023-05-05 第一三共株式会社 用于选择性制造抗体-药物缀合物的方法
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CN111470998B (zh) 2020-06-28 2020-09-25 上海皓元生物医药科技有限公司 用于合成喜树碱衍生物的中间体及其制备方法和用途
WO2022121981A1 (zh) * 2020-12-11 2022-06-16 微境生物医药科技(上海)有限公司 新型喜树碱衍生物、含其的组合物和其用途
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MX2023008716A (es) * 2021-02-05 2023-08-02 Sichuan Kelun Biotech Biopharmaceutical Co Ltd Compuesto de camptotecina, metodo de preparacion del mismo y aplicacion del mismo.
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CN120112312A (zh) 2022-10-18 2025-06-06 Tubulis 股份有限公司 新型抗-tpbg抗体和基于其的抗体-药物偶联物、其治疗方法及用途
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CN117417346B (zh) * 2023-09-11 2025-07-25 常州合全药业有限公司 喜树碱类衍生物的制备方法
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Also Published As

Publication number Publication date
NO920201D0 (no) 1992-01-15
GR3020395T3 (en) 1996-09-30
KR100191193B1 (ko) 1999-06-15
JPH0559061A (ja) 1993-03-09
AU1018592A (en) 1992-07-23
IE920079A1 (en) 1992-07-29
FI920194A0 (fi) 1992-01-16
FI920194A7 (fi) 1992-07-17
EP0495432B1 (en) 1996-05-29
DE69211023D1 (de) 1996-07-04
JP3008226B2 (ja) 2000-02-14
HK1001561A1 (en) 1998-06-26
AU640549B2 (en) 1993-08-26
DK0495432T3 (da) 1996-10-21
FI103047B (fi) 1999-04-15
ATE138661T1 (de) 1996-06-15
FI103047B1 (fi) 1999-04-15
CA2059305A1 (en) 1992-07-17
NO180448B (no) 1997-01-13
CA2059305C (en) 2001-07-31
EP0495432A1 (en) 1992-07-22
DE69211023T2 (de) 1997-01-09
NO920201L (no) 1992-07-17
RU2071476C1 (ru) 1997-01-10
NO180448C (no) 1997-04-23
KR920014816A (ko) 1992-08-25

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