NO920201L - Heksacyklisk forbindelse - Google Patents

Heksacyklisk forbindelse

Info

Publication number: NO920201L
Authority: NO; Norway
Prior art keywords: compound; hexacyclic; relationship; antitumour; abundantly
Prior art date: 1991-01-16

Application number

NO92920201A

Other languages

English (en)

Other versions

NO920201D0 (no

NO180448B (no

NO180448C (no

Inventor

Hirofumi Terasawa

Akio Ejima

Satoru Ohsuki

Koichi Uoto

Original Assignee

Daiichi Seiyaku Co

Yakult Honsha Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-16

Filing date

1992-01-15

Publication date

1992-07-17

1992-01-15 Application filed by Daiichi Seiyaku Co, Yakult Honsha Kk filed Critical Daiichi Seiyaku Co

1992-01-15 Publication of NO920201D0 publication Critical patent/NO920201D0/no

1992-07-17 Publication of NO920201L publication Critical patent/NO920201L/no

1997-01-13 Publication of NO180448B publication Critical patent/NO180448B/no

1997-04-23 Publication of NO180448C publication Critical patent/NO180448C/no

Links

-1 aminoketone compound Chemical class 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Luminescent Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Lubricants (AREA)
Fats And Perfumes (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Liquid Crystal Substances (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO920201A 1991-01-16 1992-01-15 Heksacyklisk forbindelse NO180448C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1581291		1991-01-16

Publications (4)

Publication Number	Publication Date
NO920201D0 NO920201D0 (no)	1992-01-15
NO920201L true NO920201L (no)	1992-07-17
NO180448B NO180448B (no)	1997-01-13
NO180448C NO180448C (no)	1997-04-23

Family

ID=11899258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO920201A NO180448C (no)	1991-01-16	1992-01-15	Heksacyklisk forbindelse

Country Status (14)

Country	Link
EP (1)	EP0495432B1 (no)
JP (1)	JP3008226B2 (no)
KR (1)	KR100191193B1 (no)
AT (1)	ATE138661T1 (no)
AU (1)	AU640549B2 (no)
CA (1)	CA2059305C (no)
DE (1)	DE69211023T2 (no)
DK (1)	DK0495432T3 (no)
ES (1)	ES2090366T3 (no)
FI (1)	FI103047B1 (no)
GR (1)	GR3020395T3 (no)
IE (1)	IE920079A1 (no)
NO (1)	NO180448C (no)
RU (1)	RU2071476C1 (no)

Families Citing this family (73)

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US5658920A (en) *	1991-01-16	1997-08-19	Daiichi Pharmaceutical Co., Ltd.	Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
US5849945A (en) *	1995-02-22	1998-12-15	Daiichi Pharmaceutical Co., Ltd.	Aminotetralone derivatives and preparation process thereof
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
US5663177A (en) *	1995-05-31	1997-09-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs
FR2768431B1 (fr) *	1997-08-29	2000-03-24	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
FR2790261B1 (fr) *	1999-02-26	2004-09-10	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
FR2757515B1 (fr) *	1996-12-20	2000-05-05	Sod Conseils Rech Applic	Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
IN189180B (no) *	1997-07-09	2003-01-04	Chong Kun Dang Corp
FR2772763B1 (fr) *	1997-12-24	2004-01-23	Sod Conseils Rech Applic	Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2790474B1 (fr) *	1999-03-05	2001-04-06	Synthelabo	Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
AR030207A1 (es) *	2000-04-07	2003-08-13	Daiichi Seiyaku Co	Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma
CN1464874A (zh) *	2001-05-08	2003-12-31	三井化学株式会社	1,5－二氨基萘的制备方法
ATE398131T1 (de) *	2001-11-30	2008-07-15	Chugai Pharmaceutical Co Ltd	Kondensierte camptothecine als antitumormittel
KR100501439B1 (ko) *	2002-09-27	2005-07-18	현대자동차주식회사	차량 충돌시 연료 누출 방지장치
WO2004073601A2 (en) *	2003-02-21	2004-09-02	Chugai Seiyaku Kabushiki Kaisha	Process for the preparation of hexacyclic camptothecin derivatives
UA88008C2 (en)	2004-04-09	2009-09-10	Чугей Сейяку Кабусики Кайся	Water-soluble prodrugs
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US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
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TW201026715A (en)	2008-12-23	2010-07-16	Pharmasset Inc	Nucleoside phosphoramidates
JP6104504B2 (ja)	2008-12-23	2017-03-29	ギリアドファーマセットエルエルシー	ヌクレオシド類似体
CL2011000716A1 (es)	2010-03-31	2012-04-20	Gilead Pharmasset Llc	Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
WO2014057687A1 (ja)	2012-10-11	2014-04-17	第一三共株式会社	抗体－薬物コンジュゲート
WO2014061277A1 (ja)	2012-10-19	2014-04-24	第一三共株式会社	親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
PT3088419T (pt)	2013-12-25	2019-01-11	Daiichi Sankyo Co Ltd	Conjugado de anticorpo anti-trop2-fármaco
HRP20190431T1 (hr)	2014-01-31	2019-04-19	Daiichi Sankyo Company, Limited	Anti-her2 antitijelo-lijek konjugat
ES2754348T3 (es)	2014-04-10	2020-04-17	Daiichi Sankyo Co Ltd	Conjugado de (anticuerpo anti-HER2)-fármaco
CN111228511B (zh)	2014-04-10	2024-06-18	第一三共株式会社	抗her3抗体-药物偶联物
CN116059395A (zh)	2015-06-29	2023-05-05	第一三共株式会社	用于选择性制造抗体-药物缀合物的方法
AU2017341000B2 (en)	2016-10-07	2024-11-28	Daiichi Sankyo Company, Limited	Therapy for drug-resistant cancer by administration of anti-HER2 antibody/drug conjugate
EP3552626A4 (en)	2016-12-12	2020-06-10	Daiichi Sankyo Company, Limited	ASSOCIATION OF AN ANTIBODY DRUG CONJUGATE AND AN IMMUNE CONTROL POINT INHIBITOR
EP3572428A4 (en)	2017-01-17	2020-12-30	Daiichi Sankyo Company, Limited	ANTI-BODY ANTI-GPR20 AND ANTI-BODY-DRUG CONJUGATE ANTI-GPR20
TWI855528B (zh)	2017-05-15	2024-09-11	日商第一三共股份有限公司	抗體-藥物結合物之製造方法
JP7248578B2 (ja)	2017-08-31	2023-03-29	第一三共株式会社	抗体－薬物コンジュゲートの新規製造方法
KR20250084239A (ko)	2017-08-31	2025-06-10	다이이찌 산쿄 가부시키가이샤	항체-약물 콘주게이트의 개량 제조 방법
HRP20240756T1 (hr)	2018-05-18	2024-09-13	Daiichi Sankyo Co., Ltd.	Anti-muc1-eksatekan antitijelo-lijek konjugat
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EP3831412A4 (en)	2018-07-31	2022-04-27	Daiichi Sankyo Company, Limited	TREATMENT OF METASTATIC BRAIN TUMOR BY ADMINISTRATION OF AN ANTIBODY-DRUG CONJUGATE
CR20210541A (es) *	2019-03-29	2021-12-20	Medimmune Ltd	Compuestos y conjugados de estos
TW202140076A (zh) *	2020-01-22	2021-11-01	英商梅迪繆思有限公司	化合物及其軛合物
CA3166732A1 (en) *	2020-01-22	2021-07-29	Medimmune Limited	Compounds and conjugates thereof
CN111470998B (zh)	2020-06-28	2020-09-25	上海皓元生物医药科技有限公司	用于合成喜树碱衍生物的中间体及其制备方法和用途
WO2022121981A1 (zh) *	2020-12-11	2022-06-16	微境生物医药科技(上海)有限公司	新型喜树碱衍生物、含其的组合物和其用途
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WO2022171115A1 (zh) *	2021-02-09	2022-08-18	微境生物医药科技(上海)有限公司	用于adc制备的喜树碱衍生物
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US12545716B2 (en)	2021-07-19	2026-02-10	Immunome, Inc.	Immunoconjugates and methods
US11806405B1 (en)	2021-07-19	2023-11-07	Zeno Management, Inc.	Immunoconjugates and methods
CN115703712A (zh) *	2021-08-17	2023-02-17	江苏迈威康新药研发有限公司	5,8-二氨基-3,4-二氢-2h-1-萘酮的合成方法以及其中采用的中间体化合物
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US20250059143A1 (en) *	2021-10-26	2025-02-20	Shanghai Best-Link Bioscience, Llc	Camptothecin derivative intermediate, and preparation method therefor and use thereof
EP4429709A1 (en)	2021-11-09	2024-09-18	Tubulis GmbH	Conjugates comprising a phosphorus (v) and a camptothecin moiety
US11814394B2 (en)	2021-11-16	2023-11-14	Genequantum Healthcare (Suzhou) Co., Ltd.	Exatecan derivatives, linker-payloads, and conjugates and thereof
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CN115160403B (zh) *	2022-07-05	2025-06-27	博石丰生命科技(南通)有限公司	特异性拓扑异构酶抑制剂和可用于抗体药物偶联物及其制备方法
WO2024012566A2 (en)	2022-07-15	2024-01-18	Genequantum Healthcare (Suzhou) Co., Ltd.	Antibody, linkers, payload, conjugates and applications thereof
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CN120112313A (zh)	2022-10-18	2025-06-06	Tubulis 股份有限公司	具有新型napi2b抗体的新型抗体药物偶联物、其治疗方法和用途
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EP4637832A1 (en)	2022-12-22	2025-10-29	Tubulis GmbH	Conjugates comprising a phosphorus(v) moiety and a drug
TW202434547A (zh) *	2023-01-18	2024-09-01	大陸商上海森輝醫藥有限公司	一種四氫－１－萘胺及其衍生物的製備方法
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4939255A (en) *	1987-06-24	1990-07-03	Daiichi Pharmaceutical Co., Ltd.	Hexa-cyclic camptothecin derivatives

1991
- 1991-12-04 JP JP03320688A patent/JP3008226B2/ja not_active Expired - Fee Related
1992
- 1992-01-10 IE IE007992A patent/IE920079A1/en not_active IP Right Cessation
- 1992-01-13 ES ES92100449T patent/ES2090366T3/es not_active Expired - Lifetime
- 1992-01-13 AT AT92100449T patent/ATE138661T1/de not_active IP Right Cessation
- 1992-01-13 DK DK92100449.5T patent/DK0495432T3/da active
- 1992-01-13 DE DE69211023T patent/DE69211023T2/de not_active Expired - Fee Related
- 1992-01-13 EP EP92100449A patent/EP0495432B1/en not_active Expired - Lifetime
- 1992-01-13 KR KR1019920000352A patent/KR100191193B1/ko not_active Expired - Fee Related
- 1992-01-14 CA CA002059305A patent/CA2059305C/en not_active Expired - Fee Related
- 1992-01-14 AU AU10185/92A patent/AU640549B2/en not_active Ceased
- 1992-01-15 NO NO920201A patent/NO180448C/no unknown
- 1992-01-15 RU SU925010678A patent/RU2071476C1/ru not_active IP Right Cessation
- 1992-01-16 FI FI920194A patent/FI103047B1/fi not_active IP Right Cessation
1996
- 1996-06-28 GR GR960401767T patent/GR3020395T3/el unknown

Also Published As

Publication number	Publication date
NO920201D0 (no)	1992-01-15
GR3020395T3 (en)	1996-09-30
KR100191193B1 (ko)	1999-06-15
JPH0559061A (ja)	1993-03-09
AU1018592A (en)	1992-07-23
IE920079A1 (en)	1992-07-29
FI920194A0 (fi)	1992-01-16
FI920194A7 (fi)	1992-07-17
EP0495432B1 (en)	1996-05-29
DE69211023D1 (de)	1996-07-04
JP3008226B2 (ja)	2000-02-14
HK1001561A1 (en)	1998-06-26
AU640549B2 (en)	1993-08-26
ES2090366T3 (es)	1996-10-16
DK0495432T3 (da)	1996-10-21
FI103047B (fi)	1999-04-15
ATE138661T1 (de)	1996-06-15
FI103047B1 (fi)	1999-04-15
CA2059305A1 (en)	1992-07-17
NO180448B (no)	1997-01-13
CA2059305C (en)	2001-07-31
EP0495432A1 (en)	1992-07-22
DE69211023T2 (de)	1997-01-09
RU2071476C1 (ru)	1997-01-10
NO180448C (no)	1997-04-23
KR920014816A (ko)	1992-08-25

Publication	Publication Date	Title
NO920201D0 (no)	1992-01-15	Heksacyklisk forbindelse
DK344488A (da)	1989-02-24	Hexacycliske forbindelser
CA2100258A1 (en)	1992-07-12	Acridine Derivatives
NO983487D0 (no)	1998-07-29	Derivater av camptothecin for anvendelse ved behandling av kreft
GR3007919T3 (no)	1993-08-31
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
HUT49600A (en)	1989-10-30	Process for producing substituted flavonoid deriatives and salts, thereof, as well as pharmaceutical compositions comprising such compounds
ATE93838T1 (de)	1993-09-15	Triphenylmethan-derivate.
NO920614L (no)	1992-03-24	Forbindelse med antitumorvirkning og fremstilling derav
ES2147749T3 (es)	2000-10-01	Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
FI884077A0 (fi)	1988-09-05	Amidfoereningar, foerfarande foer deras framstaellning och dessa innehaollande kompositioner foer aktivering av gastrisk motorfunktion.
ES2033279T3 (es)	1993-03-16	Procedimiento para preparar un compuesto a base de quinolina.
DE69810373D1 (de)	2003-02-06	Pyrrolidin Derivate, Anti-ulcus und Antibakterielle Arzneimittel
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