ATE138663T1 - Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel - Google Patents

Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel

Info

Publication number: ATE138663T1
Authority: AT; Austria
Prior art keywords: hydrogen; group; sec; oxothiolans; derivatives
Prior art date: 1987-10-28

Application number

AT88310040T

Other languages

English (en)

Inventor

Abraham Fisher

Ishai Karton

Original Assignee

Israel State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-28

Filing date

1988-10-26

Publication date

1996-06-15

1988-10-26 Application filed by Israel State filed Critical Israel State

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138663T1 publication Critical patent/ATE138663T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229910052722 tritium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D497/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compositions Of Macromolecular Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT88310040T 1987-10-28 1988-10-26 Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel ATE138663T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11447387A	1987-10-28	1987-10-28
US07/189,210 US4876260A (en)	1987-10-28	1988-05-02	Oxathiolanes

Publications (1)

Publication Number	Publication Date
ATE138663T1 true ATE138663T1 (de)	1996-06-15

Family

ID=26812231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88310040T ATE138663T1 (de)	1987-10-28	1988-10-26	Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel

Country Status (13)

Country	Link
US (1)	US4876260A (de)
EP (1)	EP0314444B1 (de)
JP (1)	JP2753280B2 (de)
KR (1)	KR910007979B1 (de)
AT (1)	ATE138663T1 (de)
AU (1)	AU608903B2 (de)
CA (1)	CA1315791C (de)
DE (1)	DE3855325T2 (de)
DK (1)	DK175064B1 (de)
ES (1)	ES2087854T3 (de)
IL (1)	IL87834A (de)
NO (1)	NO167806C (de)
NZ (1)	NZ226415A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
JP2683783B2 (ja) *	1992-07-10	1997-12-03	雪印乳業株式会社	シェーグレン症候群治療剤
DE4343838C2 (de) *	1993-12-22	1998-07-09	Lohmann Therapie Syst Lts	Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6572880B2 (en)	1996-10-24	2003-06-03	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
US6479074B2 (en)	1996-10-24	2002-11-12	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
US6290986B1 (en)	1996-10-24	2001-09-18	Pharmaceutical Applications Associates, Llc	Method and composition for transdermal administration of pharmacologic agents
ZA984637B (en)	1997-05-30	1998-12-21	Neurosearch As	Spiro-quinuclidine derivatives their preparation and use
US20040209849A1 (en) *	1998-11-27	2004-10-21	Sanochemia Pharmazeutika Aktiengesellschaft	Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) *	1999-01-14	2010-04-07	第一三共株式会社	皮膚乾燥症治療剤
US6433168B1 (en)	1999-07-26	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
EP2320660B8 (de)	2001-11-29	2015-09-09	Godo Kaisha IP Bridge 1	Entfernungsverfahren für die Codierungsverzerrung
MXPA04010921A (es) *	2002-05-03	2005-05-27	Israel Inst Biolog Res	Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos.
EP2035420A2 (de) *	2006-06-20	2009-03-18	Wyeth a Corporation of the State of Delaware	Kv1.5-kaliumkanal-hemmer
US8143400B2 (en) *	2008-01-10	2012-03-27	Apotex Pharmachem Inc.	Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
CN102317289A (zh) *	2008-11-23	2012-01-11	辉瑞大药厂	作为β分泌酶抑制剂的内酰胺
US9034891B2 (en)	2009-01-26	2015-05-19	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
KR20150116466A (ko)	2009-01-26	2015-10-15	이스라엘 인스티튜트 포 바이올로지컬 리서치	이환형 헤테로사이클릭 스피로 화합물
CN101798311A (zh) *	2010-04-07	2010-08-11	天津炜杰凯华科技有限公司	顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2146962A1 (en) *	1971-07-28	1973-03-09	Yoshitomi Pharmaceutical	Aza-spirodecanones - useful in treating gastric disorders
IL48452A (en) *	1975-11-11	1979-07-25	Purdue Frederick Co	Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
IL48453A (en) *	1975-11-11	1980-06-30	Purdue Frederick Co	Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
US4855290A (en) *	1985-05-10	1989-08-08	State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research	Derivatives of quinuclidine
ZA868369B (en) *	1986-01-10	1987-11-25	Israel State	Derivatives of quinuclidine
IL87234A (en) *	1987-08-13	1992-02-16	Israel Inst Biolog Res	Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

1988
- 1988-05-02 US US07/189,210 patent/US4876260A/en not_active Expired - Lifetime
- 1988-09-22 IL IL87834A patent/IL87834A/xx active Protection Beyond IP Right Term
- 1988-09-30 NZ NZ226415A patent/NZ226415A/xx unknown
- 1988-10-12 AU AU23671/88A patent/AU608903B2/en not_active Expired
- 1988-10-26 ES ES88310040T patent/ES2087854T3/es not_active Expired - Lifetime
- 1988-10-26 AT AT88310040T patent/ATE138663T1/de not_active IP Right Cessation
- 1988-10-26 EP EP88310040A patent/EP0314444B1/de not_active Expired - Lifetime
- 1988-10-26 DE DE3855325T patent/DE3855325T2/de not_active Expired - Lifetime
- 1988-10-27 DK DK198805986A patent/DK175064B1/da not_active IP Right Cessation
- 1988-10-27 NO NO884790A patent/NO167806C/no not_active IP Right Cessation
- 1988-10-27 CA CA000581526A patent/CA1315791C/en not_active Expired - Lifetime
- 1988-10-28 KR KR1019880014136A patent/KR910007979B1/ko not_active Expired
- 1988-10-28 JP JP63271085A patent/JP2753280B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0314444A2 (de)	1989-05-03
DK175064B1 (da)	2004-05-17
KR910007979B1 (ko)	1991-10-05
DE3855325D1 (de)	1996-07-04
AU608903B2 (en)	1991-04-18
CA1315791C (en)	1993-04-06
IL87834A (en)	1992-05-25
EP0314444A3 (en)	1990-11-07
ES2087854T3 (es)	1996-08-01
NO884790L (no)	1989-05-02
NO167806B (no)	1991-09-02
US4876260A (en)	1989-10-24
KR890006641A (ko)	1989-06-15
DK598688A (da)	1989-04-29
NO167806C (no)	1991-12-11
NO884790D0 (no)	1988-10-27
DK598688D0 (da)	1988-10-27
DE3855325T2 (de)	1996-10-10
AU2367188A (en)	1989-05-04
EP0314444B1 (de)	1996-05-29
IL87834A0 (en)	1989-03-31
JPH0262883A (ja)	1990-03-02
NZ226415A (en)	1990-05-28
JP2753280B2 (ja)	1998-05-18

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2009-01-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE138663T1 (de)	1996-06-15	Oxothiolane und derivate, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als arzneimittel
NO152902C (no)	1985-12-11	Analogifremgangsmaae for fremstilling av terapeutisk virksomme 1-alkyl-2-aminotetralinderivater
DE69305276D1 (de)	1996-11-14	Arylglycinamidderivate, Verfahren zur deren Herstellung und deren Verwendung zur Therapie der Dysurie
DE68922478D1 (de)	1995-06-08	Pyrazoloisoquinoline-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
ATE18549T1 (de)	1986-03-15	1-carboxyalkanoylindolin-2-carbonsaeure-ester, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie ihre therapeutische verwendung.
NO881835L (no)	1988-10-31	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
EP0404737A3 (de)	1992-03-11	R(-)3-Quinuklidinol-Derivate
IL94592A0 (en)	1991-04-15	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
NO169391C (no)	1992-06-17	Analogifremgangsmaate for fremstilling av et terapeutisk aktivt (-)-cis-quinuklidin og syreaddisjonssalter derav
DE68903019D1 (de)	1992-11-05	4,5,6,7-tetrahydroisothiazolo (4,5-c)pyridin-derivate und isomere.
DE69130266D1 (de)	1998-11-05	Optisch wirksame Alkylendioxybenzolderivate und ihre Verwendung als Arzneimittel
EP0299076A4 (en)	1991-01-09	5-hydroxyindole-3-carboxamide compound and medicinal use thereof
ATE86993T1 (de)	1993-04-15	Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
NO173010C (no)	1993-10-13	Analogifremgangsmaate for fremstilling av terapeutisk aktivt sulfonanilid
ATE57928T1 (de)	1990-11-15	1-alkyl-ergolinyl-thioharnstoffderivate.
GB1510370A (en)	1978-05-10	Pharmaceutical preparations for the treatment of coronary heart diseases
ATE63550T1 (de)	1991-06-15	Neue 1-/ 3-(2-dialkylaminoaethoxy)-2-thienyl/-3phenyl-1-propanone und ihre saeureadditionssalze und verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
EP0301466A3 (en)	1990-09-12	Uricosuric composition
TH13944A (th)	1994-05-20	สารประกอบเฮเทโรไซคลิค