DK598688A - Spiro-oxathiolan/quinuclidin - Google Patents

Spiro-oxathiolan/quinuclidin

Info

Publication number: DK598688A
Authority: DK; Denmark
Prior art keywords: hydrogen; group; sec; oxathiolane; aminoalkyl
Prior art date: 1987-10-28

Application number

DK598688A

Other languages

English (en)

Other versions

DK175064B1 (da

DK598688D0 (da

Inventor

Abraham Fisher

Ishai Karton

Original Assignee

Israel State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-28

Filing date

1988-10-27

Publication date

1989-04-29

1988-10-27 Application filed by Israel State filed Critical Israel State

1988-10-27 Publication of DK598688D0 publication Critical patent/DK598688D0/da

1989-04-29 Publication of DK598688A publication Critical patent/DK598688A/da

2004-05-17 Application granted granted Critical

2004-05-17 Publication of DK175064B1 publication Critical patent/DK175064B1/da

Links

SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229910052722 tritium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D497/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK198805986A 1987-10-28 1988-10-27 Spiro-oxathiolan/quinuclidinforbindelser, præparat indeholdende disse og anvendelse af disse til fremstilling af et farmaceutisk præparat DK175064B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US11447387A	1987-10-28	1987-10-28
US11447387		1987-10-28
US07/189,210 US4876260A (en)	1987-10-28	1988-05-02	Oxathiolanes
US18921088		1988-05-02

Publications (3)

Publication Number	Publication Date
DK598688D0 DK598688D0 (da)	1988-10-27
DK598688A true DK598688A (da)	1989-04-29
DK175064B1 DK175064B1 (da)	2004-05-17

Family

ID=26812231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198805986A DK175064B1 (da)	1987-10-28	1988-10-27	Spiro-oxathiolan/quinuclidinforbindelser, præparat indeholdende disse og anvendelse af disse til fremstilling af et farmaceutisk præparat

Country Status (13)

Country	Link
US (1)	US4876260A (da)
EP (1)	EP0314444B1 (da)
JP (1)	JP2753280B2 (da)
KR (1)	KR910007979B1 (da)
AT (1)	ATE138663T1 (da)
AU (1)	AU608903B2 (da)
CA (1)	CA1315791C (da)
DE (1)	DE3855325T2 (da)
DK (1)	DK175064B1 (da)
ES (1)	ES2087854T3 (da)
IL (1)	IL87834A (da)
NO (1)	NO167806C (da)
NZ (1)	NZ226415A (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
JP2683783B2 (ja) *	1992-07-10	1997-12-03	雪印乳業株式会社	シェーグレン症候群治療剤
DE4343838C2 (de) *	1993-12-22	1998-07-09	Lohmann Therapie Syst Lts	Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6572880B2 (en)	1996-10-24	2003-06-03	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
US6479074B2 (en)	1996-10-24	2002-11-12	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
US6290986B1 (en)	1996-10-24	2001-09-18	Pharmaceutical Applications Associates, Llc	Method and composition for transdermal administration of pharmacologic agents
NZ500643A (en)	1997-05-30	2001-12-21	Neurosearch As	Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
US20040209849A1 (en) *	1998-11-27	2004-10-21	Sanochemia Pharmazeutika Aktiengesellschaft	Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) *	1999-01-14	2010-04-07	第一三共株式会社	皮膚乾燥症治療剤
US6433168B1 (en)	1999-07-26	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
KR100929078B1 (ko)	2001-11-29	2009-11-30	파나소닉 주식회사	코딩 왜곡 제거 방법
US7439251B2 (en) *	2002-05-03	2008-10-21	Israel Institute For Biological Research	Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
EP2035420A2 (en) *	2006-06-20	2009-03-18	Wyeth a Corporation of the State of Delaware	Kv1.5 potassium channel inhibitors
US8143400B2 (en) *	2008-01-10	2012-03-27	Apotex Pharmachem Inc.	Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
CA2743584A1 (en) *	2008-11-23	2010-05-27	Pfizer Inc.	Lactams as beta secretase inhibitors
CA2750777C (en)	2009-01-26	2018-04-03	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
US9034891B2 (en)	2009-01-26	2015-05-19	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
CN101798311A (zh) *	2010-04-07	2010-08-11	天津炜杰凯华科技有限公司	顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2146962A1 (en) *	1971-07-28	1973-03-09	Yoshitomi Pharmaceutical	Aza-spirodecanones - useful in treating gastric disorders
IL48452A (en) *	1975-11-11	1979-07-25	Purdue Frederick Co	Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
IL48453A (en) *	1975-11-11	1980-06-30	Purdue Frederick Co	Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
US4855290A (en) *	1985-05-10	1989-08-08	State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research	Derivatives of quinuclidine
ZA868369B (en) *	1986-01-10	1987-11-25	Israel State	Derivatives of quinuclidine
IL87234A (en) *	1987-08-13	1992-02-16	Israel Inst Biolog Res	Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

1988
- 1988-05-02 US US07/189,210 patent/US4876260A/en not_active Expired - Lifetime
- 1988-09-22 IL IL87834A patent/IL87834A/xx active Protection Beyond IP Right Term
- 1988-09-30 NZ NZ226415A patent/NZ226415A/xx unknown
- 1988-10-12 AU AU23671/88A patent/AU608903B2/en not_active Expired
- 1988-10-26 ES ES88310040T patent/ES2087854T3/es not_active Expired - Lifetime
- 1988-10-26 EP EP88310040A patent/EP0314444B1/en not_active Expired - Lifetime
- 1988-10-26 AT AT88310040T patent/ATE138663T1/de not_active IP Right Cessation
- 1988-10-26 DE DE3855325T patent/DE3855325T2/de not_active Expired - Lifetime
- 1988-10-27 CA CA000581526A patent/CA1315791C/en not_active Expired - Lifetime
- 1988-10-27 DK DK198805986A patent/DK175064B1/da not_active IP Right Cessation
- 1988-10-27 NO NO884790A patent/NO167806C/no not_active IP Right Cessation
- 1988-10-28 KR KR1019880014136A patent/KR910007979B1/ko not_active Expired
- 1988-10-28 JP JP63271085A patent/JP2753280B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3855325T2 (de)	1996-10-10
KR890006641A (ko)	1989-06-15
JPH0262883A (ja)	1990-03-02
ATE138663T1 (de)	1996-06-15
IL87834A0 (en)	1989-03-31
AU2367188A (en)	1989-05-04
NZ226415A (en)	1990-05-28
NO884790D0 (no)	1988-10-27
CA1315791C (en)	1993-04-06
EP0314444A3 (en)	1990-11-07
EP0314444A2 (en)	1989-05-03
JP2753280B2 (ja)	1998-05-18
EP0314444B1 (en)	1996-05-29
ES2087854T3 (es)	1996-08-01
US4876260A (en)	1989-10-24
NO884790L (no)	1989-05-02
DK175064B1 (da)	2004-05-17
AU608903B2 (en)	1991-04-18
DE3855325D1 (de)	1996-07-04
NO167806B (no)	1991-09-02
IL87834A (en)	1992-05-25
KR910007979B1 (ko)	1991-10-05
NO167806C (no)	1991-12-11
DK598688D0 (da)	1988-10-27

Legal Events

Date	Code	Title	Description
2008-11-17	PUP	Patent expired

Publication	Publication Date	Title
DK598688D0 (da)	1988-10-27	Oxathiolanderivater
CA2066640A1 (en)	1991-04-15	Heterocyclic compounds
NZ240676A (en)	1993-05-26	Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof
DE3470420D1 (en)	1988-05-19	Novel 1,8-naphthyridine derivatives, and process for preparation thereof
EP0205247A3 (en)	1988-02-03	Derivatives of quinuclidine
DE68914292D1 (de)	1994-05-11	Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
ATE143943T1 (de)	1996-10-15	Arylglycinamidderivate, verfahren zur deren herstellung und deren verwendung zur therapie der dysurie
ES8601202A1 (es)	1985-10-16	Procedimiento para la produccion de espirosuccinimidas
JO1077B1 (en)	1982-07-10	New heterocyclic derivatives of phenoxiamine, methods of preparation and use as a local anesthetic.
DK0573318T3 (da)	1999-10-11	4-phenylcarbamoyl-3-isoxazolcarboxylsyreforbindelser, fremgangsmåde til deres fremstilling, farmaceutiske præparater med in
ZA873350B (en)	1988-01-27	Substituted pyridine herbicides
HU903489D0 (en)	1990-10-28	Process for producing serotonine-2-receptor antagonistic heterocyclic compounds
HUT75647A (en)	1997-05-28	Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia
NO169391C (no)	1992-06-17	Analogifremgangsmaate for fremstilling av et terapeutisk aktivt (-)-cis-quinuklidin og syreaddisjonssalter derav
DK423188A (da)	1989-01-29	Svovlforbindelser, fremgangsmaade til deres fremstilling samt laegemidler indeholdende disse forbindelser
FI862694A0 (fi)	1986-06-25	Nya i 11-staellning substituerade 5,11-dihydro-6h-pyrido/2,3-b//1,4/benzodiazepin-6-oner, foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel.
ES8305359A1 (es)	1983-04-01	Un procedimiento para la preparacion de benzamitas sustituidas.
CA1267150C (en)	1990-03-27	THIABICYCLOHEPTANE SUBSTITUTION DERIVATIVES OF AMINO-PROSTAGLANDIN ANALOGS
ES2000133A6 (es)	1987-12-16	Procedimiento pra preparar un derivado de triazol con actividad reguladora del crecimiento de las plantas
NO164901C (no)	1990-11-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive tetraoxo-3,7-diazabicyclo (3,3,1)-nonanforbindelser.
ES478072A1 (es)	1979-07-01	Un procedimiento de preparacion de 2-metoxi-benzamidas.
HUT51614A (en)	1990-05-28	Process for producing cardio-protective and suitable for treating ischemic illnesses pharmaceutical compositions containing nitriferous heterocyclic compounds as active agent as well as for producing the active agents