ATE139231T1 - Verfahren zur herstellung von castanospermin - Google Patents

Verfahren zur herstellung von castanospermin

Info

Publication number: ATE139231T1
Authority: AT; Austria
Prior art keywords: castanospermine; substituted; producing; starting; hydroxypyrrolidinone
Prior art date: 1990-03-12

Application number

AT91103682T

Other languages

English (en)

Inventor

Peter B Anzeveno

Laura J Creemer

Paul T Angell

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-12

Filing date

1991-03-11

Publication date

1996-06-15

1991-03-11 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE139231T1 publication Critical patent/ATE139231T1/de

Links

JDVVGAQPNNXQDW-WCMLQCRESA-N Castanospermine Natural products O[C@H]1[C@@H](O)[C@H]2[C@@H](O)CCN2C[C@H]1O JDVVGAQPNNXQDW-WCMLQCRESA-N 0.000 title abstract 3
JDVVGAQPNNXQDW-TVNFTVLESA-N Castinospermine Chemical compound C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2[C@@H](O)CCN21 JDVVGAQPNNXQDW-TVNFTVLESA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
JQBCKRZQAMELAD-UHFFFAOYSA-N 1-hydroxypyrrolidin-2-one Chemical class ON1CCCC1=O JQBCKRZQAMELAD-UHFFFAOYSA-N 0.000 abstract 1
CWLUFVAFWWNXJZ-UHFFFAOYSA-N 1-hydroxypyrrolidine Chemical class ON1CCCC1 CWLUFVAFWWNXJZ-UHFFFAOYSA-N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229950002441 glucurolactone Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
230000009467 reduction Effects 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT91103682T 1990-03-12 1991-03-11 Verfahren zur herstellung von castanospermin ATE139231T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/492,507 US5066807A (en)	1990-03-12	1990-03-12	Process for the preparation of castanospermine

Publications (1)

Publication Number	Publication Date
ATE139231T1 true ATE139231T1 (de)	1996-06-15

Family

ID=23956525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91103682T ATE139231T1 (de)	1990-03-12	1991-03-11	Verfahren zur herstellung von castanospermin

Country Status (15)

Country	Link
US (1)	US5066807A (de)
EP (1)	EP0446832B1 (de)
JP (1)	JP3019269B2 (de)
KR (1)	KR0160136B1 (de)
AT (1)	ATE139231T1 (de)
AU (1)	AU630543B2 (de)
CA (1)	CA2037608C (de)
DE (1)	DE69120108T2 (de)
DK (1)	DK0446832T3 (de)
ES (1)	ES2090156T3 (de)
GR (1)	GR3020707T3 (de)
HU (1)	HU210048B (de)
IE (1)	IE910803A1 (de)
IL (1)	IL97487A (de)
ZA (1)	ZA911742B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5288875A (en) *	1991-08-14	1994-02-22	Cha Jin K	Synthesis of (-)-swainsonine and intermediate compounds employed in such synthesis
ES2114566T3 (es) *	1991-08-09	1998-06-01	Nycomed Innovation Ab	Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear.
GB0110832D0 (en) *	2001-05-03	2001-06-27	Virogen Ltd	Antiviral compounds
JP2008515816A (ja) *	2004-10-06	2008-05-15	ミジェニックスインコーポレイテッド	カスタノスペルミンを含有する、併用抗ウイルス組成物およびその使用方法
US10377818B2 (en)	2015-01-30	2019-08-13	The Board Of Trustees Of The Leland Stanford Junior University	Method of treating glioma
KR101966101B1 (ko)	2017-11-27	2019-04-05	주식회사 인트켐	결정성장 촉진형 하이브리드 자기치유 혼화재의 제조방법과 그 자기치유 혼화재를 이용한 시멘트 결합재 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1315276C (en) *	1987-07-02	1993-03-30	Paul S. Liu	Castanospermine esters and glycosides
US4970317A (en) *	1989-08-08	1990-11-13	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of castanospermine esters
US5227479A (en) *	1989-12-20	1993-07-13	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of nojirimycin and related compounds

1990
- 1990-03-12 US US07/492,507 patent/US5066807A/en not_active Expired - Lifetime
1991
- 1991-03-06 CA CA002037608A patent/CA2037608C/en not_active Expired - Lifetime
- 1991-03-06 AU AU72640/91A patent/AU630543B2/en not_active Expired
- 1991-03-08 ZA ZA911742A patent/ZA911742B/xx unknown
- 1991-03-08 IL IL9748791A patent/IL97487A/en not_active IP Right Cessation
- 1991-03-11 JP JP3069414A patent/JP3019269B2/ja not_active Expired - Lifetime
- 1991-03-11 IE IE080391A patent/IE910803A1/en not_active IP Right Cessation
- 1991-03-11 HU HU91790A patent/HU210048B/hu unknown
- 1991-03-11 DK DK91103682.0T patent/DK0446832T3/da active
- 1991-03-11 DE DE69120108T patent/DE69120108T2/de not_active Expired - Lifetime
- 1991-03-11 ES ES91103682T patent/ES2090156T3/es not_active Expired - Lifetime
- 1991-03-11 KR KR1019910003856A patent/KR0160136B1/ko not_active Expired - Lifetime
- 1991-03-11 EP EP91103682A patent/EP0446832B1/de not_active Expired - Lifetime
- 1991-03-11 AT AT91103682T patent/ATE139231T1/de not_active IP Right Cessation
1996
- 1996-08-02 GR GR960402071T patent/GR3020707T3/el unknown

Also Published As

Publication number	Publication date
EP0446832A2 (de)	1991-09-18
DE69120108D1 (de)	1996-07-18
DE69120108T2 (de)	1997-02-06
JPH04217978A (ja)	1992-08-07
AU630543B2 (en)	1992-10-29
DK0446832T3 (da)	1996-07-01
US5066807A (en)	1991-11-19
EP0446832A3 (en)	1992-03-25
ZA911742B (en)	1991-12-24
EP0446832B1 (de)	1996-06-12
ES2090156T3 (es)	1996-10-16
AU7264091A (en)	1991-09-12
IL97487A0 (en)	1992-06-21
JP3019269B2 (ja)	2000-03-13
IE910803A1 (en)	1991-09-25
GR3020707T3 (en)	1996-11-30
KR0160136B1 (ko)	1998-12-01
CA2037608A1 (en)	1991-09-13
HU210048B (en)	1995-01-30
HU910790D0 (en)	1991-09-30
CA2037608C (en)	2000-11-21
KR910016749A (ko)	1991-11-05
IL97487A (en)	1995-05-26
HUT57208A (en)	1991-11-28

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Legal Events

Date	Code	Title
1997-02-15	UEP	Publication of translation of european patent specification
2011-05-15	EEIH	Change in the person of patent owner
2011-06-15	EELA	Cancelled due to lapse of time