ATE99281T1 - Verfahren zur herstellung von 7-substituierten hept-6-en- und heptansaeuren und derivaten davon. - Google Patents

Verfahren zur herstellung von 7-substituierten hept-6-en- und heptansaeuren und derivaten davon.

Info

Publication number: ATE99281T1
Authority: AT; Austria
Prior art keywords: derivatives; preparation; heptanoic acids; hept; substituted
Prior art date: 1988-10-13

Application number

AT89118906T

Other languages

English (en)

Inventor

Kau-Ming Chen

Prasad Koteswara Kapa

George T Lee

Oljan Repic

Petr Hess

Michel Crevoisier

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-13

Filing date

1989-10-11

Publication date

1994-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26945992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE99281(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-11 Application filed by Sandoz Ag filed Critical Sandoz Ag

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99281T1 publication Critical patent/ATE99281T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
-1 7-SUBSTITUTED HEPT-6-EN Chemical class 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
125000004185 ester group Chemical group 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
241000845077 Iare Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000422 delta-lactone group Chemical group 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Obesity (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT89118906T 1988-10-13 1989-10-11 Verfahren zur herstellung von 7-substituierten hept-6-en- und heptansaeuren und derivaten davon. ATE99281T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25747588A	1988-10-13	1988-10-13
US35553189A	1989-05-22	1989-05-22
EP89118906A EP0363934B1 (de)	1988-10-13	1989-10-11	Verfahren zur Herstellung von 7-substituierten Hept-6-en- und Heptansäuren und Derivaten davon

Publications (1)

Publication Number	Publication Date
ATE99281T1 true ATE99281T1 (de)	1994-01-15

Family

ID=26945992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89118906T ATE99281T1 (de)	1988-10-13	1989-10-11	Verfahren zur herstellung von 7-substituierten hept-6-en- und heptansaeuren und derivaten davon.

Country Status (24)

Country	Link
EP (2)	EP0562643A3 (de)
JP (1)	JP2853227B2 (de)
KR (1)	KR0162656B1 (de)
AT (1)	ATE99281T1 (de)
AU (1)	AU636122B2 (de)
BG (1)	BG60555B1 (de)
CA (1)	CA2000553C (de)
CZ (1)	CZ283316B6 (de)
DE (1)	DE68911834T2 (de)
DK (1)	DK175073B1 (de)
ES (1)	ES2060712T3 (de)
FI (1)	FI98063C (de)
HK (1)	HK49496A (de)
HU (1)	HU207993B (de)
IE (2)	IE63477B1 (de)
IL (1)	IL91941A (de)
MY (1)	MY105067A (de)
NO (1)	NO174623C (de)
NZ (1)	NZ230973A (de)
RO (1)	RO109732B1 (de)
SG (1)	SG139553A1 (de)
SK (1)	SK280845B6 (de)
WO (1)	WO1990003962A1 (de)
YU (1)	YU48466B (de)

Families Citing this family (29)

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US5118853A (en) *	1988-10-13	1992-06-02	Sandoz Ltd.	Processes for the synthesis of 3-disubstituted aminoacroleins
US5290946A (en) *	1988-10-13	1994-03-01	Sandoz Ltd.	Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5112819A (en) *	1989-10-10	1992-05-12	Glaxo Group Limited	Imidazole derivatives, pharmaceutical compositions and use
DE4424525A1 (de) *	1994-07-12	1995-01-26	Elmar Meyer	Dauermagnet-Kolbenmotor
GT199800127A (es)	1997-08-29	2000-02-01		Combinaciones terapeuticas.
SK2692002A3 (en)	1999-08-30	2002-07-02	Aventis Pharma Gmbh	Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001092223A1 (en) *	2000-05-26	2001-12-06	Ciba Specialty Chemicals Holding Inc.	Process for the preparation of indole derivatives and intermediates of the process
US7777006B2 (en)	2002-12-31	2010-08-17	Csl Behring L.L.C.	Method for purification of alpha-1-antitrypsin
JPWO2004094377A1 (ja) *	2003-04-24	2006-07-13	ダイセル化学工業株式会社	光学活性なジヒドロキシヘプテン酸エステルの分離方法
JP2007524619A (ja)	2003-06-18	2007-08-30	テバファーマシューティカルインダストリーズリミティド	フルバスタチンナトリウム結晶型、その調製方法、これを含有する組成物、およびその使用法
US7368468B2 (en)	2003-06-18	2008-05-06	Teva Pharmaceutical Industries Ltd.	Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
US7368581B2 (en)	2003-06-18	2008-05-06	Teva Pharmaceutical Industries Ltd.	Process for the preparation of fluvastatin sodium crystal from XIV
EP1722780A4 (de)	2003-11-26	2008-12-17	Univ Duke	Verfahren zur prävention oder behandlung von glaukom
US7851624B2 (en)	2003-12-24	2010-12-14	Teva Pharamaceutical Industries Ltd.	Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
EP1847529B1 (de)	2006-04-20	2009-05-20	F.I.S. Fabbrica Italiana Sintetici S.P.A.	Verfahren zur Herstellung von Fluvastatin-Natrium
SI2373609T1 (sl)	2008-12-19	2013-12-31	Krka, D.D., Novo Mesto	Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (de)	2009-10-29	2011-06-01	KRKA, D.D., Novo Mesto	Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte.
US20140370060A1 (en)	2012-02-02	2014-12-18	The University Of Sydney	Tear Film Stability
BR112015026513A2 (pt)	2013-04-17	2017-07-25	Pfizer	derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
RS66416B1 (sr)	2019-01-18	2025-02-28	Astrazeneca Ab	6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene
TW202545529A (zh)	2024-02-05	2025-12-01	瑞典商阿斯特捷利康公司	組合療法
WO2025196155A1 (en)	2024-03-20	2025-09-25	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
WO2025196153A1 (en)	2024-03-20	2025-09-25	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
TW202539678A (zh)	2024-03-20	2025-10-16	瑞典商阿斯特捷利康公司	Ｐｃｓｋ９抑制劑及其使用方法
WO2025238159A1 (en)	2024-05-16	2025-11-20	Astrazeneca Ab	Combination therapy comprising azd0780 and ezetimibe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB945536A (en) *	1961-09-08	1964-01-02	Istituto Chemioterapico	Method of preparing ª -amino-acroleins
AU570021B2 (en) *	1982-11-22	1988-03-03	Novartis Ag	Analogs of mevalolactone
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4571428A (en) *	1983-07-08	1986-02-18	Sandoz, Inc.	6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) *	1984-04-03	1987-03-17	Sandoz Corp.	Preparation of olefinic compounds and intermediates thereof
FI860755A0 (fi) *	1984-06-22	1986-02-20	Sandoz Ag	Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning.
JPS62501009A (ja) *	1984-12-04	1987-04-23	サンド・アクチエンゲゼルシヤフト	メバロノラクトンのインデン同族体及びその誘導体
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
JPS6322056A (ja) *	1986-04-30	1988-01-29	サンド・アクチエンゲゼルシヤフト	オレフイン性化合物の製造法
NZ221717A (en) *	1986-09-10	1990-08-28	Sandoz Ltd	Azaindole and indolizine derivatives and pharmaceutical compositions

1989
- 1989-10-11 DE DE68911834T patent/DE68911834T2/de not_active Expired - Lifetime
- 1989-10-11 AU AU43448/89A patent/AU636122B2/en not_active Expired
- 1989-10-11 JP JP1510605A patent/JP2853227B2/ja not_active Expired - Lifetime
- 1989-10-11 EP EP19930106005 patent/EP0562643A3/en not_active Ceased
- 1989-10-11 MY MYPI89001403A patent/MY105067A/en unknown
- 1989-10-11 YU YU197389A patent/YU48466B/sh unknown
- 1989-10-11 AT AT89118906T patent/ATE99281T1/de not_active IP Right Cessation
- 1989-10-11 KR KR1019900701243A patent/KR0162656B1/ko not_active Expired - Lifetime
- 1989-10-11 ES ES89118906T patent/ES2060712T3/es not_active Expired - Lifetime
- 1989-10-11 RO RO145326A patent/RO109732B1/ro unknown
- 1989-10-11 SG SG200602066-3A patent/SG139553A1/en unknown
- 1989-10-11 HU HU896048A patent/HU207993B/hu unknown
- 1989-10-11 IE IE327789A patent/IE63477B1/en not_active IP Right Cessation
- 1989-10-11 NZ NZ230973A patent/NZ230973A/xx unknown
- 1989-10-11 IL IL9194189A patent/IL91941A/en not_active IP Right Cessation
- 1989-10-11 WO PCT/EP1989/001201 patent/WO1990003962A1/en not_active Ceased
- 1989-10-11 EP EP89118906A patent/EP0363934B1/de not_active Expired - Lifetime
- 1989-10-11 IE IE940109A patent/IE940109L/xx unknown
- 1989-10-12 SK SK5797-89A patent/SK280845B6/sk unknown
- 1989-10-12 CZ CS895797A patent/CZ283316B6/cs not_active IP Right Cessation
- 1989-10-12 CA CA002000553A patent/CA2000553C/en not_active Expired - Lifetime
1990
- 1990-06-07 BG BG92179A patent/BG60555B1/bg unknown
- 1990-06-12 FI FI902935A patent/FI98063C/fi active IP Right Grant
- 1990-06-12 NO NO902598A patent/NO174623C/no unknown
- 1990-06-13 DK DK199001446A patent/DK175073B1/da not_active IP Right Cessation
1996
- 1996-03-21 HK HK49496A patent/HK49496A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0562643A2 (de)	1993-09-29
YU48466B (sh)	1998-08-14
KR900701723A (ko)	1990-12-04
CA2000553A1 (en)	1990-04-13
FI98063B (fi)	1996-12-31
FI98063C (fi)	1997-04-10
NO174623C (no)	1994-06-08
CA2000553C (en)	2001-12-04
JP2853227B2 (ja)	1999-02-03
SK579789A3 (en)	2000-08-14
NO902598D0 (no)	1990-06-12
NO174623B (no)	1994-02-28
NO902598L (no)	1990-08-07
NZ230973A (en)	1993-03-26
DE68911834D1 (de)	1994-02-10
IE63477B1 (en)	1995-04-19
ES2060712T3 (es)	1994-12-01
AU636122B2 (en)	1993-04-22
KR0162656B1 (ko)	1999-01-15
SK280845B6 (sk)	2000-08-14
CZ579789A3 (en)	1997-11-12
DE68911834T2 (de)	1994-06-23
HK49496A (en)	1996-03-29
EP0363934A1 (de)	1990-04-18
HU896048D0 (en)	1990-11-28
DK175073B1 (da)	2004-05-24
FI902935A0 (fi)	1990-06-12
YU197389A (en)	1990-12-31
JPH03501735A (ja)	1991-04-18
RO109732B1 (ro)	1995-05-30
IE940109L (en)	1990-04-13
MY105067A (en)	1994-07-30
BG60555B1 (en)	1995-08-28
AU4344889A (en)	1990-05-01
DK144690D0 (da)	1990-06-13
DK144690A (da)	1990-06-13
BG92179A (bg)	1993-12-24
HUT53860A (en)	1990-12-28
IE893277L (en)	1990-04-13
IL91941A0 (en)	1990-06-10
EP0562643A3 (en)	1994-05-18
EP0363934B1 (de)	1993-12-29
SG139553A1 (en)	2008-02-29
CZ283316B6 (cs)	1998-02-18
WO1990003962A1 (en)	1990-04-19
IL91941A (en)	1994-10-21
HU207993B (en)	1993-07-28

Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
2010-01-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE99281T1 (de)	1994-01-15	Verfahren zur herstellung von 7-substituierten hept-6-en- und heptansaeuren und derivaten davon.
ES8103048A1 (es)	1981-02-16	Un procedimiento para preparar derivados del acido 4-amino-3-quimoleincarboxilico.
DE69738154D1 (de)	2007-10-31	Optische auflösung von methylphenidat mittels 0,0'-bisaroyl-weinsäuren
ES8706622A1 (es)	1987-07-01	Procedimiento para preparar alfa-aminoacidos sustituidos
GR930100259A (el)	1994-02-28	Μικροβιακή μέ?οδος παρασκευής μεβινολίνης.
ATE117989T1 (de)	1995-02-15	Prostaglandinanaloge enthaltende lipidemulsion.
DK691288D0 (da)	1988-12-12	Cyclopropanderivater
ATE114637T1 (de)	1994-12-15	Verfahren zur herstellung von antikonvulsanten cyclischen aminosäureverbindungen.
EP0366041A3 (de)	1991-10-23	Imido-percarbonsäuren
ATE46322T1 (de)	1989-09-15	Verfahren zur herstellung von bestatin-derivaten und deren zwischenprodukte.
GB1514389A (en)	1978-06-14	Glycerides with antibacterial properties
MY101645A (en)	1991-12-31	Phosphoric esters and process for preparing the same.
DE68907873D1 (de)	1993-09-02	Arylessigsaeuremonoester, deren herstellung und verwendung.
ATE25680T1 (de)	1987-03-15	Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
GR1000469B (el)	1992-07-30	Mεθοδος παρασκευης κινολινοκαρβοξυλικων οξεων.
ATE213493T1 (de)	2002-03-15	Verfahren zur herstellung von methoximinophenylglyoxylsäure-derivaten
BG49274A3 (bg)	1991-09-16	Метод за получаване на естери на l-аминодикарбонова киселина
ATE123028T1 (de)	1995-06-15	Phospholipase-a2-inhibitor, verfahren zu seiner herstellung und diesen enthaltende pharmazeutische oder veterinäre zusammensetzungen.
ATE16696T1 (de)	1985-12-15	Verfahren zur herstellung von 3-alkyl-6-methylbeta-resorcylsaeureestern.
ATE103598T1 (de)	1994-04-15	Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem.
SE405732B (sv)	1978-12-27	Sett att framstella derivat av dl-7-aminodesacetoxicefalosporansyra eller dl-7-tritylaminodesacetoxicefalosporansyra
ATE104974T1 (de)	1994-05-15	Verfahren zur herstellung eines pyrrol-derivats.
DE59002152D1 (de)	1993-09-09	Verfahren zur herstellung von 4-ketocarbonsaeuren und deren ester.
ES2083961T3 (es)	1996-05-01	Acidos 3-anilino-2-hidroxicarbonil-4-tiofenoaceticos.
GR1000201B (el)	1992-03-20	Mέ?οδος για την παρασκευή του 1-κυκλοπροπυλο-6-φ?ορο-1,4-διϋδρο-4-οξο-7κινολίνο-3-καρβοξυλικού οξέος δομικού λί?ου παρασκευής των 1-κυκλοπρόπυλο-6-φ?όρο-1,4-διϋδρο-4οξο-7-πιπεράζινο-κινολινο 3καρβοξυλικών οξέων.