ATE139344T1 - Verfahren zum nachweis eines cobalamin- und folsäuredefizits - Google Patents
Verfahren zum nachweis eines cobalamin- und folsäuredefizitsInfo
- Publication number
- ATE139344T1 ATE139344T1 AT91203329T AT91203329T ATE139344T1 AT E139344 T1 ATE139344 T1 AT E139344T1 AT 91203329 T AT91203329 T AT 91203329T AT 91203329 T AT91203329 T AT 91203329T AT E139344 T1 ATE139344 T1 AT E139344T1
- Authority
- AT
- Austria
- Prior art keywords
- cobalamine
- detecting
- folic acid
- acid deficiency
- deficiency
- Prior art date
Links
- 206010016880 Folate deficiency Diseases 0.000 title 1
- 208000010188 Folic Acid Deficiency Diseases 0.000 title 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/18—Sulfur containing
- Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/933,553 US4940658A (en) | 1986-11-20 | 1986-11-20 | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE139344T1 true ATE139344T1 (de) | 1996-06-15 |
Family
ID=25464166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87310138T ATE87104T1 (de) | 1986-11-20 | 1987-11-17 | Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. |
| AT91203329T ATE139344T1 (de) | 1986-11-20 | 1987-11-17 | Verfahren zum nachweis eines cobalamin- und folsäuredefizits |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87310138T ATE87104T1 (de) | 1986-11-20 | 1987-11-17 | Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4940658A (de) |
| EP (2) | EP0269352B1 (de) |
| JP (3) | JP2574339B2 (de) |
| AT (2) | ATE87104T1 (de) |
| CA (1) | CA1298536C (de) |
| DE (2) | DE3784852T2 (de) |
| HK (1) | HK1007799A1 (de) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US5374560A (en) * | 1989-04-03 | 1994-12-20 | The University Of Colorado, Inc. | Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid |
| US5457055A (en) * | 1986-11-20 | 1995-10-10 | The University Of Colorado Foundation | Diagnostic method for cobalamin deficiency |
| US5438017A (en) * | 1989-05-01 | 1995-08-01 | The University Of Colorado Foundation, Inc. | Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency |
| DK138090D0 (da) * | 1990-06-06 | 1990-06-06 | Novo Nordisk As | Diagnostisk analysemetode |
| US6207651B1 (en) | 1996-08-02 | 2001-03-27 | Metabolite Laboratories | Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6 |
| US20030203873A1 (en) * | 1992-12-29 | 2003-10-30 | Allen Robert H | Method for treatment of neuropsychiatric disorders |
| US5478729A (en) * | 1994-04-28 | 1995-12-26 | Syntex (U.S.A.) Inc. | Immunoassay for homocysteine |
| US5559038A (en) * | 1994-05-04 | 1996-09-24 | The Regents Of The University Of Colorado | Gas chromatography/mass spectrometry determination of oxidized sulfhydryl amino acids |
| US5800979A (en) * | 1994-12-01 | 1998-09-01 | Kolhouse; J. Fred | Gas chromatography/mass spectrometric determination of folic acid coenzymes |
| US6265391B1 (en) | 1995-10-17 | 2001-07-24 | Upsher-Smith Laboratories, Inc. | Method for preventing peripheral nerve damage |
| US5932624A (en) * | 1995-10-17 | 1999-08-03 | Herbert; Victor D. | Vitamin supplement composition |
| WO1997027764A1 (en) | 1996-01-31 | 1997-08-07 | South Alabama Medical Science Foundation | Food and vitamin preparations containing the natural isomer of reduced folates |
| GB9617683D0 (en) | 1996-08-23 | 1996-10-02 | Univ Glasgow | Homocysteine desulphurase |
| ATE275834T1 (de) | 1997-03-20 | 2004-10-15 | Coventry Group Ltd | Nährungsergänzungsmittel für kardiovasküläre gesundheit |
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| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
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| US6468762B1 (en) | 1997-07-24 | 2002-10-22 | Anticancer, Inc. | High specificity homocysteinases |
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| US6066467A (en) * | 1997-07-24 | 2000-05-23 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| US5985540A (en) * | 1997-07-24 | 1999-11-16 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| US6300136B1 (en) * | 1997-09-03 | 2001-10-09 | The Trustees Of The University Of Pennsylvania | Methods for diagnosis and treatment of tumors in humans |
| AU4835599A (en) | 1998-06-29 | 2000-01-17 | Edwin F. Ullman | Assay for homocysteine |
| US6284219B1 (en) | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
| US6953666B1 (en) | 1998-11-06 | 2005-10-11 | Emory University | Biomarkers for oxidative stress |
| US6174696B1 (en) | 1999-11-12 | 2001-01-16 | Genzyme Corporation | Method for the determination of homocysteine |
| US6426194B1 (en) | 1999-02-01 | 2002-07-30 | Anticancer, Inc. | Homogeneous enzymatic assay for vitamin B6 and improvements in H2S detection |
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| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
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| JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
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| JPWO2013099949A1 (ja) * | 2011-12-28 | 2015-05-11 | 扶桑薬品工業株式会社 | 血漿中の酢酸濃度の測定方法 |
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| KR102085946B1 (ko) | 2017-07-24 | 2020-03-06 | 충남대학교 산학협력단 | 무세포 단백질 합성 시스템을 이용한 아미노산의 정량 방법 |
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| CN116818966A (zh) * | 2023-06-29 | 2023-09-29 | 山东英盛生物技术有限公司 | Lc-ms/ms测定甲基丙二酸、同型半胱氨酸及其相关代谢产物方法 |
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| US4447547A (en) * | 1980-04-09 | 1984-05-08 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| US4451571A (en) * | 1981-04-06 | 1984-05-29 | University Patents, Inc. | Preparation of samples for vitamin B12 and/or folate assay and assay |
| US4427780A (en) * | 1981-08-13 | 1984-01-24 | University Patents, Inc. | Method for assaying vitamin-containing compositions for vitamin analogues |
| US4467037A (en) * | 1982-03-01 | 1984-08-21 | The Curators Of The University Of Missouri | Silylation of amino acids |
| GB2168478A (en) * | 1984-11-26 | 1986-06-18 | Scan Limited M | Analysis of protein etc using mass spectrometry |
| JPS62292190A (ja) * | 1986-06-11 | 1987-12-18 | 日本ユニオンスペシャル株式会社 | ミシンのル−パ糸の糸繰り装置 |
| US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
-
1986
- 1986-11-20 US US06/933,553 patent/US4940658A/en not_active Expired - Lifetime
-
1987
- 1987-11-17 EP EP87310138A patent/EP0269352B1/de not_active Expired - Lifetime
- 1987-11-17 AT AT87310138T patent/ATE87104T1/de not_active IP Right Cessation
- 1987-11-17 EP EP91203329A patent/EP0486118B1/de not_active Expired - Lifetime
- 1987-11-17 AT AT91203329T patent/ATE139344T1/de not_active IP Right Cessation
- 1987-11-17 DE DE8787310138T patent/DE3784852T2/de not_active Expired - Fee Related
- 1987-11-17 DE DE3751840T patent/DE3751840T2/de not_active Expired - Fee Related
- 1987-11-19 CA CA000552222A patent/CA1298536C/en not_active Expired - Lifetime
- 1987-11-20 JP JP62292190A patent/JP2574339B2/ja not_active Expired - Lifetime
-
1994
- 1994-04-26 JP JP6088530A patent/JP2579434B2/ja not_active Expired - Fee Related
-
1995
- 1995-07-07 JP JP7171988A patent/JP2577878B2/ja not_active Expired - Fee Related
-
1998
- 1998-06-26 HK HK98107047A patent/HK1007799A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0269352A3 (en) | 1988-07-06 |
| JPS63221249A (ja) | 1988-09-14 |
| HK1007799A1 (en) | 1999-04-23 |
| ATE87104T1 (de) | 1993-04-15 |
| JPH0854398A (ja) | 1996-02-27 |
| DE3784852T2 (de) | 1993-06-24 |
| EP0269352B1 (de) | 1993-03-17 |
| DE3751840D1 (de) | 1996-07-18 |
| US4940658A (en) | 1990-07-10 |
| DE3784852D1 (de) | 1993-04-22 |
| CA1298536C (en) | 1992-04-07 |
| DE3751840T2 (de) | 1997-01-09 |
| JPH0749348A (ja) | 1995-02-21 |
| JP2577878B2 (ja) | 1997-02-05 |
| EP0486118A1 (de) | 1992-05-20 |
| JP2574339B2 (ja) | 1997-01-22 |
| EP0486118B1 (de) | 1996-06-12 |
| EP0269352A2 (de) | 1988-06-01 |
| JP2579434B2 (ja) | 1997-02-05 |
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| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |