ATE139439T1 - Pharmazeutische formulierung und pharmazeutisches verfahren - Google Patents

Pharmazeutische formulierung und pharmazeutisches verfahren

Info

Publication number: ATE139439T1
Authority: AT; Austria
Prior art keywords: pharmaceutical; formulation; solid phase; cyclosporin; solution
Prior art date: 1991-04-19

Application number

AT92922779T

Other languages

English (en)

Inventor

Jill P Adler-Moore

William A Ernst

Original Assignee

Nexstar Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-19

Filing date

1992-04-20

Publication date

1996-07-15

1992-04-20 Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc

1996-07-15 Application granted granted Critical

1996-07-15 Publication of ATE139439T1 publication Critical patent/ATE139439T1/de

Links

238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
239000007790 solid phase Substances 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000000887 hydrating effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92922779T 1991-04-19 1992-04-20 Pharmazeutische formulierung und pharmazeutisches verfahren ATE139439T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68781291A	1991-04-19	1991-04-19

Publications (1)

Publication Number	Publication Date
ATE139439T1 true ATE139439T1 (de)	1996-07-15

Family

ID=24761958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92922779T ATE139439T1 (de)	1991-04-19	1992-04-20	Pharmazeutische formulierung und pharmazeutisches verfahren

Country Status (11)

Country	Link
US (3)	US5688525A (de)
EP (1)	EP0580817B1 (de)
JP (1)	JP2721041B2 (de)
AT (1)	ATE139439T1 (de)
AU (1)	AU657961B2 (de)
CA (1)	CA2108288C (de)
DE (1)	DE69211691T2 (de)
DK (1)	DK0580817T3 (de)
ES (1)	ES2088160T3 (de)
GR (1)	GR3020396T3 (de)
WO (1)	WO1992018104A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0697214A1 (de) *	1994-07-19	1996-02-21	Vestar, Inc.	Pharmazeutische Formulierungen mit liposomalem Cyclosporin
PT789584E (pt) *	1994-11-04	2002-03-28	Polymun Scient Immunbio Forsch	Aplicacao de superoxido-dismutase (sod) em liposomas
US5693336A (en) *	1995-06-07	1997-12-02	Nexstar Pharmaceuticals, Inc.	Blood stable liposomal cyclosporin formulations
AU6047996A (en) *	1995-06-07	1996-12-30	Nexstar Pharmaceuticals, Inc.	Liposomal cyclosporin formulations as agents for immunosuppr ession and multiple drug resistant indications
CA2202103C (en)	1996-04-11	2007-01-09	Toshiaki Tagawa	Method for preparing closed vesicles
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
ATE404172T1 (de)	1998-12-30	2008-08-15	Dexcel Ltd	Dispergierbares konzentrat zur verabreichung von cyclosporin
US6613352B2 (en)	1999-04-13	2003-09-02	Universite De Montreal	Low-rigidity liposomal formulation
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
ATE267582T1 (de) *	2000-01-20	2004-06-15	Basilea Pharmaceutica Ag	Nasal verabreichbare cyclische antimykotische peptidzusammensetzungen
US7125568B2 (en)	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
IL160761A0 (en)	2001-10-19	2004-08-31	Isotechnika Inc	Novel cyclosporin analog microemulsion preconcentrates
RU2217128C1 (ru) *	2002-07-16	2003-11-27	Закрытое акционерное общество "АИП-Наука"	Препарат для местного применения при лечении туберкулеза легких и гнойно-воспалительных заболеваний
EP1585504A4 (de) *	2002-11-06	2009-07-15	Azaya Therapeutics Inc	Proteinstabilisierte liposomale formulierungen pharmazeutischer wirkstoffe
WO2006014035A1 (en) *	2004-08-06	2006-02-09	Biospectrum, Inc.	Multiple layered liposome and preparation method thereof
US20060165641A1 (en) *	2005-01-18	2006-07-27	Kumar Pillai	Cosmetic compositions containing combinations of hydroxamate derivatives and antioxidants in a liposomal delivery system
US20070026061A1 (en) *	2005-05-25	2007-02-01	Nahid Ali	Liposomal formulation and use thereof
JP2009514969A (ja)	2005-11-09	2009-04-09	コンビナトアールエックスインコーポレーティッド	医学的状態を治療するための方法、組成物、およびキット
JPWO2008026781A1 (ja) *	2006-08-31	2010-01-21	直人奥	逆標的化脂質小胞体
KR20150065941A (ko)	2008-03-06	2015-06-15	아나코르 파마슈티칼스 인코포레이티드	소염제로써 붕소가 함유된 소분자
US8218847B2 (en)	2008-06-06	2012-07-10	Superdimension, Ltd.	Hybrid registration method
JP6205133B2 (ja)	2009-07-10	2017-09-27	プレジデントアンドフェローズオブハーバードカレッジ	抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
US20130109674A1 (en)	2009-12-18	2013-05-02	Achelios Therapeutics Llc	Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions
WO2011094450A1 (en)	2010-01-27	2011-08-04	Anacor Pharmaceuticals, Inc	Boron-containing small molecules
LT3191135T (lt)	2014-09-12	2020-11-25	Genentech, Inc.	Anti-her2 antikūnai ir imunokonjugatai
WO2016089893A1 (en)	2014-12-01	2016-06-09	Achelios Therapeutics Inc.	Methods and compositions for treating migraine and conditions associated with pain
KR20180069782A (ko)	2015-08-03	2018-06-25	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	하전 이온 채널 블록커 및 이용 방법
CA3033867A1 (en)	2016-08-17	2018-02-22	Solstice Biologics, Ltd.	Polynucleotide constructs
US11597744B2 (en)	2017-06-30	2023-03-07	Sirius Therapeutics, Inc.	Chiral phosphoramidite auxiliaries and methods of their use
EA202092893A1 (ru)	2018-06-27	2021-04-19	Брес Терапьютикс Гмбх	Фармацевтические композиции в лиофилизированной форме
US10934263B2 (en)	2019-03-11	2021-03-02	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
MX2021010869A (es)	2019-03-11	2022-01-19	Nocion Therapeutics Inc	Bloqueadores de canales iónicos sustituidos por éster y métodos para su uso.
US10780083B1 (en)	2019-03-11	2020-09-22	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
US10828287B2 (en)	2019-03-11	2020-11-10	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
AU2020235888A1 (en)	2019-03-11	2021-09-30	Nocion Therapeutics, Inc.	Charged ION channel blockers and methods for use
CA3139559A1 (en)	2019-05-09	2020-11-12	Apkarian Technologies Llc	Methods and compositions for treating pain
US12089902B2 (en)	2019-07-30	2024-09-17	Coviden Lp	Cone beam and 3D fluoroscope lung navigation
US20220307013A1 (en)	2019-08-30	2022-09-29	The Regents Of The University Of California	Gene fragment overexpression screening methodologies, and uses thereof
US10933055B1 (en)	2019-11-06	2021-03-02	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
CN114828845A (zh)	2019-11-06	2022-07-29	诺西恩医疗公司	带电的离子通道阻滞剂及其使用方法
CN119118953A (zh)	2020-03-11	2024-12-13	诺西恩医疗公司	带电的离子通道阻滞剂及其使用方法
US12162851B2 (en)	2020-03-11	2024-12-10	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
WO2022243866A1 (en) *	2021-05-17	2022-11-24	Mahmoud Reza Jaafari	Method for producing liposomes entrapping cyclosporine a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4663167A (en) *	1984-04-16	1987-05-05	The Board Of Regents Of The University Of Texas System	Composition and method for treatment of disseminated fungal infections in mammals
US4797285A (en) *	1985-12-06	1989-01-10	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	Lipsome/anthraquinone drug composition and method
US5023087A (en) *	1986-02-10	1991-06-11	Liposome Technology, Inc.	Efficient method for preparation of prolonged release liposome-based drug delivery system
US4963362A (en) *	1987-08-07	1990-10-16	Regents Of The University Of Minnesota	Freeze-dried liposome mixture containing cyclosporin
US5000887A (en) *	1988-05-17	1991-03-19	Liposome Technology, Inc.	Preparation of uniform-size liposomes
US4952405A (en) *	1988-10-20	1990-08-28	Liposome Technology, Inc.	Method of treating M. avium infection
AU6428890A (en) *	1989-09-12	1991-04-18	Regents Of The University Of California, The	Therapeutic peptides and proteins

1992
- 1992-04-20 AU AU17977/92A patent/AU657961B2/en not_active Expired
- 1992-04-20 AT AT92922779T patent/ATE139439T1/de active
- 1992-04-20 EP EP92922779A patent/EP0580817B1/de not_active Expired - Lifetime
- 1992-04-20 DE DE69211691T patent/DE69211691T2/de not_active Expired - Lifetime
- 1992-04-20 ES ES92922779T patent/ES2088160T3/es not_active Expired - Lifetime
- 1992-04-20 DK DK92922779.1T patent/DK0580817T3/da active
- 1992-04-20 CA CA002108288A patent/CA2108288C/en not_active Expired - Lifetime
- 1992-04-20 JP JP4510313A patent/JP2721041B2/ja not_active Expired - Lifetime
- 1992-04-20 WO PCT/US1992/003234 patent/WO1992018104A1/en not_active Ceased
1993
- 1993-06-30 US US08/085,673 patent/US5688525A/en not_active Expired - Lifetime
1995
- 1995-05-05 US US08/435,909 patent/US5660856A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,956 patent/US5670166A/en not_active Expired - Lifetime
1996
- 1996-06-28 GR GR960401773T patent/GR3020396T3/el unknown

Also Published As

Publication number	Publication date
CA2108288C (en)	2003-09-16
DK0580817T3 (da)	1996-08-05
US5670166A (en)	1997-09-23
JP2721041B2 (ja)	1998-03-04
CA2108288A1 (en)	1992-10-20
US5660856A (en)	1997-08-26
GR3020396T3 (en)	1996-09-30
DE69211691T2 (de)	1997-01-16
EP0580817A1 (de)	1994-02-02
DE69211691D1 (de)	1996-07-25
AU657961B2 (en)	1995-03-30
EP0580817B1 (de)	1996-06-19
JPH06510024A (ja)	1994-11-10
ES2088160T3 (es)	1996-08-01
WO1992018104A1 (en)	1992-10-29
AU1797792A (en)	1992-11-17
US5688525A (en)	1997-11-18

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Legal Events

Date	Code	Title	Description
1997-02-15	UEP	Publication of translation of european patent specification