ATE139776T1 - Trizyklische verbindungen - Google Patents
Trizyklische verbindungenInfo
- Publication number
- ATE139776T1 ATE139776T1 AT89110272T AT89110272T ATE139776T1 AT E139776 T1 ATE139776 T1 AT E139776T1 AT 89110272 T AT89110272 T AT 89110272T AT 89110272 T AT89110272 T AT 89110272T AT E139776 T1 ATE139776 T1 AT E139776T1
- Authority
- AT
- Austria
- Prior art keywords
- tricyclic compounds
- txa2
- activity
- cerebro
- preventive
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 101150100032 Tbxa2r gene Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000023589 ischemic disease Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Eye Examination Apparatus (AREA)
- Led Devices (AREA)
- Surgical Instruments (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14237488 | 1988-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE139776T1 true ATE139776T1 (de) | 1996-07-15 |
Family
ID=15313892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89110272T ATE139776T1 (de) | 1988-06-09 | 1989-06-07 | Trizyklische verbindungen |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US4999363A (de) |
| EP (1) | EP0345747B1 (de) |
| JP (1) | JPH0737416B2 (de) |
| AT (1) | ATE139776T1 (de) |
| CA (1) | CA1338625C (de) |
| DE (1) | DE68926727T2 (de) |
| ES (1) | ES2091190T3 (de) |
| GR (1) | GR3020929T3 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242931A (en) * | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
| US4999363A (en) * | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5378701A (en) * | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
| FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
| EP0685478B1 (de) * | 1993-02-16 | 2001-10-24 | Ube Industries, Ltd. | Quinolin-derivate |
| CN1052722C (zh) * | 1995-04-11 | 2000-05-24 | 中国人民解放军军事医学科学院毒物药物研究所 | 二苯并氧杂䓬或硫杂䓬衍生物、其制备方法及药物组合物 |
| AU6369696A (en) | 1995-07-17 | 1997-02-18 | Fuji Photo Film Co., Ltd. | Benzimidazole compounds |
| CA2259431A1 (en) * | 1996-07-01 | 1998-01-08 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| PL337888A1 (en) | 1997-07-03 | 2000-09-11 | Du Pont Pharm Co | Imidazoprimidines and imidazopyridines for use in treating neurological disorders |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CA2318088A1 (en) | 1998-01-21 | 1999-07-29 | Yoshisuke Nakasato | Chemokine receptor antagonists and methods of use therefor |
| AU2331999A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) * | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TW200400816A (en) * | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| CN1918151A (zh) * | 2003-12-19 | 2007-02-21 | 伊莱利利公司 | 三环甾类激素核受体调节剂 |
| JP2008530229A (ja) | 2005-02-17 | 2008-08-07 | ワイス | シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体 |
| AU2006332694A1 (en) * | 2005-12-30 | 2007-07-12 | Alantos Pharmaceuticals, Holding, Inc. | Substituted bis-amide metalloprotease inhibitors |
| US7645752B2 (en) | 2006-01-13 | 2010-01-12 | Wyeth Llc | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
| JP5189091B2 (ja) | 2006-07-14 | 2013-04-24 | イーライ リリー アンド カンパニー | グルココルチコイド受容体モジュレーターおよびその使用方法 |
| TWI431010B (zh) * | 2007-12-19 | 2014-03-21 | Lilly Co Eli | 礦皮質素受體拮抗劑及使用方法 |
| BRPI0906945A2 (pt) * | 2008-01-11 | 2015-07-14 | Lilly Co Eli | (e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide. |
| CA2722923C (en) * | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| CA2722811C (en) * | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| NZ591115A (en) * | 2008-09-26 | 2012-10-26 | Boehringer Ingelheim Int | Azaindazole compounds as ccr1 receptor antagonists |
| PH12012500775A1 (en) | 2009-10-21 | 2012-11-26 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
| US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
| WO2011071730A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| WO2012087782A1 (en) | 2010-12-23 | 2012-06-28 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3420851A (en) * | 1962-12-19 | 1969-01-07 | Pfizer & Co C | Novel dibenzoxepines |
| SE368825B (de) * | 1963-10-14 | 1974-07-22 | Pfizer | |
| US4585788A (en) * | 1973-09-06 | 1986-04-29 | American Hoechst Corporation | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives |
| US4282365A (en) * | 1978-11-24 | 1981-08-04 | Merck & Co., Inc. | Dibenz[b,e]oxepin compounds |
| US4396550A (en) * | 1980-04-22 | 1983-08-02 | Kyowa Hakko Kogyo Co., Ltd. | Dibenz [b,e] oxepin derivatives |
| JPS57139073A (en) * | 1981-02-20 | 1982-08-27 | Kyowa Hakko Kogyo Co Ltd | Novel dibenzo(b, e)oxepin derivative |
| JPS58126883A (ja) * | 1982-01-25 | 1983-07-28 | Kyowa Hakko Kogyo Co Ltd | ジベンゾ〔ｂ，ｅ〕オキセピン誘導体を含有してなる抗喘息剤 |
| JPS59227879A (ja) * | 1983-06-10 | 1984-12-21 | Kyowa Hakko Kogyo Co Ltd | ジベンゾ［ｂ，ｅ］オキセピン誘導体 |
| JPS6028972A (ja) * | 1983-06-29 | 1985-02-14 | Kyowa Hakko Kogyo Co Ltd | ジベンゾ［ｂ，ｅ］オキセピン誘導体 |
| JPS6125798A (ja) * | 1984-07-13 | 1986-02-04 | ヤマザキマザック株式会社 | ハンド支持機構 |
| JPS6147466A (ja) * | 1984-08-10 | 1986-03-07 | Dainippon Pharmaceut Co Ltd | アミン誘導体 |
| JPS61152676A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法 |
| EP0188802A3 (de) * | 1984-12-26 | 1986-08-20 | Kyowa Hakko Kogyo Co., Ltd. | Dibenz(b,e)oxepin-Derivat und antiallergisches Mittel |
| JPS61152673A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法 |
| JPS61152669A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体および抗アレルギ−剤 |
| JPS61152674A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法 |
| JPS61152675A (ja) * | 1984-12-26 | 1986-07-11 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法 |
| JPS61257981A (ja) * | 1985-05-09 | 1986-11-15 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体および抗アレルギ−剤 |
| GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| JPH0645600B2 (ja) * | 1985-12-25 | 1994-06-15 | 大日本製薬株式会社 | １，４−ジアザシクロアルカン誘導体 |
| AU7020887A (en) * | 1986-02-12 | 1987-09-09 | Dainippon Pharmaceutical Co. Ltd. | Tricyclic compounds, process for their preparation, and medicinal composition containing them |
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| JPS6317877A (ja) * | 1986-07-09 | 1988-01-25 | Kyowa Hakko Kogyo Co Ltd | ジベンズ〔ｂ，ｅ〕オキセピン誘導体及び抗アレルギ−剤 |
| US4882351A (en) * | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| AU612437B2 (en) * | 1987-12-14 | 1991-07-11 | Kyowa Hakko Kogyo Co. Ltd. | Tricyclic compounds |
| US4999363A (en) * | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5242931A (en) * | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
-
1989
- 1989-06-06 US US07/368,242 patent/US4999363A/en not_active Expired - Lifetime
- 1989-06-06 CA CA000601928A patent/CA1338625C/en not_active Expired - Fee Related
- 1989-06-07 EP EP89110272A patent/EP0345747B1/de not_active Expired - Lifetime
- 1989-06-07 DE DE68926727T patent/DE68926727T2/de not_active Expired - Fee Related
- 1989-06-07 ES ES89110272T patent/ES2091190T3/es not_active Expired - Lifetime
- 1989-06-07 AT AT89110272T patent/ATE139776T1/de not_active IP Right Cessation
- 1989-06-08 JP JP1146049A patent/JPH0737416B2/ja not_active Expired - Lifetime
-
1990
- 1990-11-14 US US07/612,446 patent/US5118701A/en not_active Expired - Fee Related
-
1992
- 1992-11-23 US US07/980,617 patent/US5302596A/en not_active Expired - Fee Related
-
1996
- 1996-09-03 GR GR960402286T patent/GR3020929T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5118701A (en) | 1992-06-02 |
| EP0345747A3 (en) | 1990-07-04 |
| CA1338625C (en) | 1996-10-01 |
| DE68926727D1 (de) | 1996-08-01 |
| EP0345747A2 (de) | 1989-12-13 |
| EP0345747B1 (de) | 1996-06-26 |
| GR3020929T3 (en) | 1996-12-31 |
| ES2091190T3 (es) | 1996-11-01 |
| US4999363A (en) | 1991-03-12 |
| JPH0291040A (ja) | 1990-03-30 |
| JPH0737416B2 (ja) | 1995-04-26 |
| DE68926727T2 (de) | 1996-11-21 |
| US5302596A (en) | 1994-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |