ATE140001T1 - Isochromanderivate - Google Patents

Isochromanderivate

Info

Publication number: ATE140001T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; group; alkoxy; hydroxy
Prior art date: 1990-05-25

Application number

AT91201119T

Other languages

English (en)

Inventor

Jean-Claude Laigle

Michel Combourieu

Nadine Simbille

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-25

Filing date

1991-05-10

Publication date

1996-07-15

1991-05-10 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1996-07-15 Application granted granted Critical

1996-07-15 Publication of ATE140001T1 publication Critical patent/ATE140001T1/de

Links

HEBMCVBCEDMUOF-UHFFFAOYSA-N isochromane Chemical class C1=CC=C2COCCC2=C1 HEBMCVBCEDMUOF-UHFFFAOYSA-N 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 methylenedioxy group Chemical group 0.000 abstract 3
125000001118 alkylidene group Chemical group 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
208000031229 Cardiomyopathies Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
206010042434 Sudden death Diseases 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000003384 isochromanyl group Chemical class C1(OCCC2=CC=CC=C12)* 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)

AT91201119T 1990-05-25 1991-05-10 Isochromanderivate ATE140001T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90401407		1990-05-25

Publications (1)

Publication Number	Publication Date
ATE140001T1 true ATE140001T1 (de)	1996-07-15

Family

ID=8205714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91201119T ATE140001T1 (de)	1990-05-25	1991-05-10	Isochromanderivate

Country Status (15)

Country	Link
EP (1)	EP0458387B1 (de)
JP (1)	JPH04253970A (de)
KR (1)	KR910020004A (de)
AT (1)	ATE140001T1 (de)
AU (1)	AU643277B2 (de)
CA (1)	CA2042861A1 (de)
DE (1)	DE69120603T2 (de)
DK (1)	DK0458387T3 (de)
ES (1)	ES2091283T3 (de)
FI (1)	FI912400L (de)
GR (1)	GR3021084T3 (de)
IE (1)	IE73232B1 (de)
NZ (1)	NZ238243A (de)
PT (1)	PT97766B (de)
ZA (1)	ZA913691B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69419778T2 (de) *	1993-12-28	1999-12-09	Pharmacia & Upjohn Co., Kalamazoo	Heterozyklische verbindungen für die behandlung von kardiovaskular- und zentralnervensystem störungen
US6943168B2 (en)	1998-06-30	2005-09-13	Neuromed Technologies Inc.	Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6492375B2 (en)	1998-06-30	2002-12-10	Neuromed Technologies, Inc.	Partially saturated calcium channel blockers
US6011035A (en) *	1998-06-30	2000-01-04	Neuromed Technologies Inc.	Calcium channel blockers
US7186726B2 (en)	1998-06-30	2007-03-06	Neuromed Pharmaceuticals Ltd.	Preferentially substituted calcium channel blockers
US6387897B1 (en)	1998-06-30	2002-05-14	Neuromed Technologies, Inc.	Preferentially substituted calcium channel blockers
US6310059B1 (en)	1998-06-30	2001-10-30	Neuromed Technologies, Inc.	Fused ring calcium channel blockers
US6951862B2 (en)	1998-06-30	2005-10-04	Neuromed Technologies, Inc.	Calcium channel blockers comprising two benzhydril moieties
CA2903746C (en)	2013-03-08	2022-08-23	Amy Hauck Newman	Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
UA122222C2 (uk) *	2015-02-11	2020-10-12	Суновіон Фармасьютикалз Інк.	Сполуки 1-гетероцикліл-ізохроманілу і аналоги для лікування розладів цнс
WO2019094856A1 (en)	2017-11-13	2019-05-16	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1552004A (en) *	1976-05-26	1979-09-05	Takeda Chemical Industries Ltd	Isochroman derivatives
EP0450689A1 (de) *	1990-04-02	1991-10-09	Akzo Nobel N.V.	Isochromanderivate

1991
- 1991-05-09 IE IE158991A patent/IE73232B1/en not_active IP Right Cessation
- 1991-05-10 ES ES91201119T patent/ES2091283T3/es not_active Expired - Lifetime
- 1991-05-10 AT AT91201119T patent/ATE140001T1/de not_active IP Right Cessation
- 1991-05-10 DE DE69120603T patent/DE69120603T2/de not_active Expired - Fee Related
- 1991-05-10 EP EP91201119A patent/EP0458387B1/de not_active Expired - Lifetime
- 1991-05-10 DK DK91201119.4T patent/DK0458387T3/da active
- 1991-05-15 ZA ZA913691A patent/ZA913691B/xx unknown
- 1991-05-17 FI FI912400A patent/FI912400L/fi not_active Application Discontinuation
- 1991-05-17 CA CA002042861A patent/CA2042861A1/en not_active Abandoned
- 1991-05-23 NZ NZ238243A patent/NZ238243A/en unknown
- 1991-05-24 KR KR1019910008399A patent/KR910020004A/ko not_active Ceased
- 1991-05-24 PT PT97766A patent/PT97766B/pt not_active IP Right Cessation
- 1991-05-24 AU AU77334/91A patent/AU643277B2/en not_active Ceased
- 1991-05-24 JP JP3222510A patent/JPH04253970A/ja active Pending
1996
- 1996-09-19 GR GR960402440T patent/GR3021084T3/el unknown

Also Published As

Publication number	Publication date
JPH04253970A (ja)	1992-09-09
DE69120603D1 (de)	1996-08-08
EP0458387A1 (de)	1991-11-27
ZA913691B (en)	1992-02-26
PT97766A (pt)	1992-03-31
EP0458387B1 (de)	1996-07-03
DE69120603T2 (de)	1997-01-02
ES2091283T3 (es)	1996-11-01
KR910020004A (ko)	1991-12-19
FI912400A0 (fi)	1991-05-17
DK0458387T3 (da)	1996-10-21
GR3021084T3 (en)	1996-12-31
IE73232B1 (en)	1997-05-21
NZ238243A (en)	1992-12-23
FI912400A7 (fi)	1991-11-26
IE911589A1 (en)	1991-12-04
AU7733491A (en)	1991-11-28
CA2042861A1 (en)	1991-11-26
PT97766B (pt)	1998-10-30
FI912400L (fi)	1991-11-26
AU643277B2 (en)	1993-11-11

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
1999-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
MX9203122A (es)	1992-07-01	Compuestos analogos de distamicina a y composiciones farmaceuticas que los contienen.
ATE24001T1 (de)	1986-12-15	Substituierte 1-hydroxyethyl-triazolyl-derivate.
LV5748A4 (lv)	1996-10-20	Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
DE69120603D1 (de)	1996-08-08	Isochromanderivate
YU12992A (sh)	1995-01-31	2-amino-1,2,3,4,-tetrahidronaftaleni supstituisani u prstenu
ES2043807T3 (es)	1994-01-01	Compuestos anticancer.
ATE143661T1 (de)	1996-10-15	Imidazonaphthyridinderivate
ATE96446T1 (de)	1993-11-15	Estramustin-ester.
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
ATE110721T1 (de)	1994-09-15	2-alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische zusammensetzungen.
ES2053896T3 (es)	1994-08-01	4,5-diariltioimidazoles 2-substituidos antihipercolesterolesmicos.
ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
FI914525A0 (fi)	1991-09-26	Foerening, anvaendning och framstaellning.
ATE105565T1 (de)	1994-05-15	Pradimicinderivate.
SE8901060D0 (sv)	1989-03-28	New compounds
FI903967A0 (fi)	1990-08-10	Nya imidazolderivat.
FR2632522B1 (fr)	1990-09-14	Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent
DK568483A (da)	1984-06-11	Tropyl- og pseudotropylalkylbenzoater
DE68911893D1 (de)	1994-02-10	Antagonisten von Leukotrien D4.