ZA913691B - Isochromane derivatives - Google Patents

Isochromane derivatives

Info

Publication number: ZA913691B
Authority: ZA; South Africa
Prior art keywords: alkyl; hydrogen; group; alkoxy; hydroxy
Prior art date: 1990-05-25

Application number

ZA913691A

Other languages

English (en)

Inventor

Michel Combourieu

Combourieu Michel

Jean-Claude Laigle

Laigle Jean-Claude

Nadine Simbille

Simbille Nadine

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-25

Filing date

1991-05-15

Publication date

1992-02-26

1991-05-15 Application filed by Akzo Nv filed Critical Akzo Nv

1992-02-26 Publication of ZA913691B publication Critical patent/ZA913691B/xx

Links

125000003384 isochromanyl group Chemical class C1(OCCC2=CC=CC=C12)* 0.000 title abstract 2
125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 methylenedioxy group Chemical group 0.000 abstract 3
125000001118 alkylidene group Chemical group 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
208000031229 Cardiomyopathies Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
206010042434 Sudden death Diseases 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)

ZA913691A 1990-05-25 1991-05-15 Isochromane derivatives ZA913691B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90401407		1990-05-25

Publications (1)

Publication Number	Publication Date
ZA913691B true ZA913691B (en)	1992-02-26

Family

ID=8205714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA913691A ZA913691B (en)	1990-05-25	1991-05-15	Isochromane derivatives

Country Status (15)

Country	Link
EP (1)	EP0458387B1 (de)
JP (1)	JPH04253970A (de)
KR (1)	KR910020004A (de)
AT (1)	ATE140001T1 (de)
AU (1)	AU643277B2 (de)
CA (1)	CA2042861A1 (de)
DE (1)	DE69120603T2 (de)
DK (1)	DK0458387T3 (de)
ES (1)	ES2091283T3 (de)
FI (1)	FI912400A7 (de)
GR (1)	GR3021084T3 (de)
IE (1)	IE73232B1 (de)
NZ (1)	NZ238243A (de)
PT (1)	PT97766B (de)
ZA (1)	ZA913691B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ277373A (en) *	1993-12-28	1998-07-28	Upjohn Co	Iso(thio)chroman-1-ylethylpiperazine and -piperidine derivatives (analogues)
US6310059B1 (en)	1998-06-30	2001-10-30	Neuromed Technologies, Inc.	Fused ring calcium channel blockers
US6951862B2 (en)	1998-06-30	2005-10-04	Neuromed Technologies, Inc.	Calcium channel blockers comprising two benzhydril moieties
US6492375B2 (en)	1998-06-30	2002-12-10	Neuromed Technologies, Inc.	Partially saturated calcium channel blockers
US6011035A (en) *	1998-06-30	2000-01-04	Neuromed Technologies Inc.	Calcium channel blockers
US6943168B2 (en)	1998-06-30	2005-09-13	Neuromed Technologies Inc.	Calcium channel inhibitors comprising benzhydril spaced from piperazine
US7186726B2 (en)	1998-06-30	2007-03-06	Neuromed Pharmaceuticals Ltd.	Preferentially substituted calcium channel blockers
US6387897B1 (en)	1998-06-30	2002-05-14	Neuromed Technologies, Inc.	Preferentially substituted calcium channel blockers
WO2014138518A2 (en)	2013-03-08	2014-09-12	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
KR102601972B1 (ko) *	2015-02-11	2023-11-13	선오비온 파마슈티컬스 인코포레이티드	중추 신경계 질환을 치료하기 위한 1-헤테로사이클릴 이소크로만일 화합물 및 유사체
WO2019094856A1 (en)	2017-11-13	2019-05-16	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1552004A (en) *	1976-05-26	1979-09-05	Takeda Chemical Industries Ltd	Isochroman derivatives
EP0450689A1 (de) *	1990-04-02	1991-10-09	Akzo Nobel N.V.	Isochromanderivate

1991
- 1991-05-09 IE IE158991A patent/IE73232B1/en not_active IP Right Cessation
- 1991-05-10 DK DK91201119.4T patent/DK0458387T3/da active
- 1991-05-10 AT AT91201119T patent/ATE140001T1/de not_active IP Right Cessation
- 1991-05-10 EP EP91201119A patent/EP0458387B1/de not_active Expired - Lifetime
- 1991-05-10 ES ES91201119T patent/ES2091283T3/es not_active Expired - Lifetime
- 1991-05-10 DE DE69120603T patent/DE69120603T2/de not_active Expired - Fee Related
- 1991-05-15 ZA ZA913691A patent/ZA913691B/xx unknown
- 1991-05-17 CA CA002042861A patent/CA2042861A1/en not_active Abandoned
- 1991-05-17 FI FI912400A patent/FI912400A7/fi not_active Application Discontinuation
- 1991-05-23 NZ NZ238243A patent/NZ238243A/en unknown
- 1991-05-24 AU AU77334/91A patent/AU643277B2/en not_active Ceased
- 1991-05-24 PT PT97766A patent/PT97766B/pt not_active IP Right Cessation
- 1991-05-24 JP JP3222510A patent/JPH04253970A/ja active Pending
- 1991-05-24 KR KR1019910008399A patent/KR910020004A/ko not_active Ceased
1996
- 1996-09-19 GR GR960402440T patent/GR3021084T3/el unknown

Also Published As

Publication number	Publication date
KR910020004A (ko)	1991-12-19
EP0458387B1 (de)	1996-07-03
CA2042861A1 (en)	1991-11-26
DE69120603D1 (de)	1996-08-08
AU643277B2 (en)	1993-11-11
FI912400L (fi)	1991-11-26
DE69120603T2 (de)	1997-01-02
FI912400A7 (fi)	1991-11-26
EP0458387A1 (de)	1991-11-27
AU7733491A (en)	1991-11-28
GR3021084T3 (en)	1996-12-31
ATE140001T1 (de)	1996-07-15
DK0458387T3 (da)	1996-10-21
JPH04253970A (ja)	1992-09-09
FI912400A0 (fi)	1991-05-17
ES2091283T3 (es)	1996-11-01
PT97766A (pt)	1992-03-31
IE73232B1 (en)	1997-05-21
IE911589A1 (en)	1991-12-04
NZ238243A (en)	1992-12-23
PT97766B (pt)	1998-10-30

Publication	Publication Date	Title
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
MX9203122A (es)	1992-07-01	Compuestos analogos de distamicina a y composiciones farmaceuticas que los contienen.
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
GR3021084T3 (en)	1996-12-31	Isochromane derivatives
YU12992A (sh)	1995-01-31	2-amino-1,2,3,4,-tetrahidronaftaleni supstituisani u prstenu
ES2043807T3 (es)	1994-01-01	Compuestos anticancer.
ATE143661T1 (de)	1996-10-15	Imidazonaphthyridinderivate
ATE96446T1 (de)	1993-11-15	Estramustin-ester.
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
DE68917772D1 (de)	1994-10-06	2-Alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische Zusammensetzungen.
ES2053896T3 (es)	1994-08-01	4,5-diariltioimidazoles 2-substituidos antihipercolesterolesmicos.
FI914525A0 (fi)	1991-09-26	Foerening, anvaendning och framstaellning.
ATE105565T1 (de)	1994-05-15	Pradimicinderivate.
FI903967A0 (fi)	1990-08-10	Nya imidazolderivat.
DE69217282D1 (de)	1997-03-20	Herstellung von 2-(2-Thienyl)Äthylamin und Synthese von Thieno(3,2-c)pyridinderivaten daraus
DK568483A (da)	1984-06-11	Tropyl- og pseudotropylalkylbenzoater
DK0455899T3 (da)	2000-06-05	Prostaglandin I-analog
DE68911893D1 (de)	1994-02-10	Antagonisten von Leukotrien D4.