ATE140224T1 - Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung - Google Patents

Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung

Info

Publication number
ATE140224T1
ATE140224T1 AT93908326T AT93908326T ATE140224T1 AT E140224 T1 ATE140224 T1 AT E140224T1 AT 93908326 T AT93908326 T AT 93908326T AT 93908326 T AT93908326 T AT 93908326T AT E140224 T1 ATE140224 T1 AT E140224T1
Authority
AT
Austria
Prior art keywords
pct
formula
image
group
aryl
Prior art date
Application number
AT93908326T
Other languages
English (en)
Inventor
Richard Friary
John J Piwinski
Jesse K Wong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE140224T1 publication Critical patent/ATE140224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93908326T 1992-03-27 1993-03-22 Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung ATE140224T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85891992A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
ATE140224T1 true ATE140224T1 (de) 1996-07-15

Family

ID=25329500

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93908326T ATE140224T1 (de) 1992-03-27 1993-03-22 Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung

Country Status (13)

Country Link
US (2) US5679692A (de)
EP (1) EP0635012B1 (de)
JP (1) JPH07505393A (de)
AT (1) ATE140224T1 (de)
AU (1) AU3918993A (de)
CA (1) CA2132848A1 (de)
DE (1) DE69303605T2 (de)
DK (1) DK0635012T3 (de)
ES (1) ES2089815T3 (de)
GR (1) GR3021194T3 (de)
HK (1) HK31197A (de)
MX (1) MX9301721A (de)
WO (1) WO1993020063A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2129995C (en) * 1992-02-13 2000-04-11 Albert A. Carr Piperidinyl thiacyclic derivatives
AU2002259147A1 (en) 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
TWI329108B (en) 2001-09-06 2010-08-21 Schering Corp 17-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
AR036812A1 (es) 2001-10-17 2004-10-06 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US7338967B2 (en) * 2004-09-10 2008-03-04 Syngenta Limited Substituted isoxazoles as fungicides
UA130467C2 (uk) * 2020-04-30 2026-02-25 Ідорсія Фармасьютікалз Лтд Похідні азетидин-3-ілметанолу як модулятори рецептора ccr6

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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CA780443A (en) * 1968-03-12 Sandoz Patents Limited 10 h-(1) benzothiopyrano (3,2-b) pyridine derivatives
NL88235C (de) * 1950-12-05
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
GB1046543A (en) * 1963-02-22 1966-10-26 Sandoz Ag Improvements in or relating to azathiaxanthene derivatives
NL132137C (de) * 1963-04-24
BE638971A (de) * 1963-10-21
US3325501A (en) * 1964-02-18 1967-06-13 Sandoz Ltd 9-[piperidylidene(4')]-1-aza-thiaxanthene-10-oxides and derivatives
US3803154A (en) * 1969-08-07 1974-04-09 Colgate Palmolive Co 11-cyclicaminoalkylidenemorphanthridines
US3803153A (en) * 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3966944A (en) * 1975-05-19 1976-06-29 Abbott Laboratories 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine as an analgesic, anti-inflammatory and agent against type III hypersensitivity disease
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3170504D1 (en) * 1980-09-02 1985-06-20 Sandoz Ag Piperidylidene derivatives, their production and pharmaceutical compositions containing them
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
EP0228893A3 (de) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Durch Aryloxyalkyl-Gruppen N-substituierte Arylalkyl heterozyklische Amine in Allergieheilverfahren
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
IL78939A (en) * 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4797489A (en) * 1987-12-02 1989-01-10 American Home Products Corp. Adamantyl- and fluorenyl-arylpiperazines and -arylpiperidines
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
NZ228889A (en) * 1988-04-28 1991-09-25 Schering Corp Fused tri- or tetracyclic heterocyclic compounds and pharmaceutical compositions
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
GB9000304D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Muscarinic receptor antagonists
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
HUT66081A (en) * 1990-10-10 1994-09-28 Schering Corp Process for preparing pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0635012B1 (de) 1996-07-10
HK31197A (en) 1997-03-21
GR3021194T3 (en) 1996-12-31
US5679692A (en) 1997-10-21
CA2132848A1 (en) 1993-10-14
DK0635012T3 (da) 1996-08-19
DE69303605D1 (de) 1996-08-14
MX9301721A (es) 1993-09-01
ES2089815T3 (es) 1996-10-01
WO1993020063A1 (en) 1993-10-14
EP0635012A1 (de) 1995-01-25
US5665735A (en) 1997-09-09
DE69303605T2 (de) 1997-01-23
JPH07505393A (ja) 1995-06-15
AU3918993A (en) 1993-11-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee