DK0635012T3 - Bis-aryl-carbinolderivater uden broer, præparater indeholdende disse og fremgangsmåder til anvendelse af disse - Google Patents

Bis-aryl-carbinolderivater uden broer, præparater indeholdende disse og fremgangsmåder til anvendelse af disse

Info

Publication number
DK0635012T3
DK0635012T3 DK93908326.7T DK93908326T DK0635012T3 DK 0635012 T3 DK0635012 T3 DK 0635012T3 DK 93908326 T DK93908326 T DK 93908326T DK 0635012 T3 DK0635012 T3 DK 0635012T3
Authority
DK
Denmark
Prior art keywords
pct
formula
image
group
bridges
Prior art date
Application number
DK93908326.7T
Other languages
English (en)
Inventor
Jesse K Wong
Richard Friary
John J Piwinski
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0635012T3 publication Critical patent/DK0635012T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93908326.7T 1992-03-27 1993-03-22 Bis-aryl-carbinolderivater uden broer, præparater indeholdende disse og fremgangsmåder til anvendelse af disse DK0635012T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85891992A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
DK0635012T3 true DK0635012T3 (da) 1996-08-19

Family

ID=25329500

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93908326.7T DK0635012T3 (da) 1992-03-27 1993-03-22 Bis-aryl-carbinolderivater uden broer, præparater indeholdende disse og fremgangsmåder til anvendelse af disse

Country Status (13)

Country Link
US (2) US5679692A (da)
EP (1) EP0635012B1 (da)
JP (1) JPH07505393A (da)
AT (1) ATE140224T1 (da)
AU (1) AU3918993A (da)
CA (1) CA2132848A1 (da)
DE (1) DE69303605T2 (da)
DK (1) DK0635012T3 (da)
ES (1) ES2089815T3 (da)
GR (1) GR3021194T3 (da)
HK (1) HK31197A (da)
MX (1) MX9301721A (da)
WO (1) WO1993020063A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016081A1 (en) * 1992-02-13 1993-08-19 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
AU2002259147A1 (en) 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US6903102B2 (en) * 2001-09-06 2005-06-07 Schering Corporation 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
PE20030705A1 (es) 2001-10-17 2003-08-21 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US7338967B2 (en) * 2004-09-10 2008-03-04 Syngenta Limited Substituted isoxazoles as fungicides
EP4143179B1 (en) 2020-04-30 2025-10-22 Idorsia Pharmaceuticals Ltd Azetidin-3-ylmethanol derivatives as ccr6 receptor modulators for the treatment of cancer

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA780443A (en) * 1968-03-12 Sandoz Patents Limited 10 h-(1) benzothiopyrano (3,2-b) pyridine derivatives
NL88063C (da) * 1950-12-05
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
GB1046543A (en) * 1963-02-22 1966-10-26 Sandoz Ag Improvements in or relating to azathiaxanthene derivatives
NL132137C (da) * 1963-04-24
BE638971A (da) * 1963-10-21
US3325501A (en) * 1964-02-18 1967-06-13 Sandoz Ltd 9-[piperidylidene(4')]-1-aza-thiaxanthene-10-oxides and derivatives
US3803154A (en) * 1969-08-07 1974-04-09 Colgate Palmolive Co 11-cyclicaminoalkylidenemorphanthridines
US3803153A (en) * 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US3966944A (en) * 1975-05-19 1976-06-29 Abbott Laboratories 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine as an analgesic, anti-inflammatory and agent against type III hypersensitivity disease
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3170504D1 (en) * 1980-09-02 1985-06-20 Sandoz Ag Piperidylidene derivatives, their production and pharmaceutical compositions containing them
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
JPS61501205A (ja) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション ８↓−クロル↓−６，１１↓−ジヒドロ↓−１１↓−（４↓−ピペリジリデン）↓−５Ｈ↓−ベンゾ〔５，６〕シクロヘプタ〔１，２−ｂ〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (en) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
IN163948B (da) * 1986-01-17 1988-12-10 Robins Co Inc A H
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4797489A (en) * 1987-12-02 1989-01-10 American Home Products Corp. Adamantyl- and fluorenyl-arylpiperazines and -arylpiperidines
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
EP0339978B1 (en) * 1988-04-28 1996-08-21 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents
CA1341044C (en) * 1988-04-28 2000-07-04 Frank J. Villani Benzopyrido piperidine, piperidylidene and peperazine compounds, compositions, methods of manufacture and methods of use
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
GB9000304D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Muscarinic receptor antagonists
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
PH31566A (en) * 1990-10-10 1998-11-03 Schering Corp Pyridine and pyridine n-oxide derivatives for diaryl methyl piperidines or piperazines and compositions and methods of use thereof.

Also Published As

Publication number Publication date
CA2132848A1 (en) 1993-10-14
ES2089815T3 (es) 1996-10-01
WO1993020063A1 (en) 1993-10-14
EP0635012B1 (en) 1996-07-10
JPH07505393A (ja) 1995-06-15
ATE140224T1 (de) 1996-07-15
EP0635012A1 (en) 1995-01-25
US5665735A (en) 1997-09-09
GR3021194T3 (en) 1996-12-31
DE69303605D1 (de) 1996-08-14
US5679692A (en) 1997-10-21
MX9301721A (es) 1993-09-01
DE69303605T2 (de) 1997-01-23
HK31197A (en) 1997-03-21
AU3918993A (en) 1993-11-08

Similar Documents

Publication Publication Date Title
ES2183935T3 (es) Isoxazoles sustituidos para el tratamiento de la inflamacion.
PT641328E (pt) Derivados aza-biciclicos em ponte como antagonistas da substancia p
SE8201145L (sv) Nya aminometyl-5 oxazolidiniska derivat, deras framstellningssett och derasterapeutiska anvendning
NO944919L (no) Fremgangsmåte for å inhibere atrofi av huden eller vagina
DK151627C (da) Analogifremgangsmaade til fremstilling af terapeutisk virksomme 4-(fenylalkenyl)-imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf.
DK0779886T3 (da) Dihydrobenzofuran og beslægtede forbindelser, der er anvendelige som antiinflammatoriske midler
UA50711C2 (uk) Антрациклінові похідні, їх застосування при лікуванні амілоїдозу та фармацевтична композиція
DK157926C (da) Analogifremgangsmaade til fremstilling af 4-(substitueret aminometyl)-imidazoler eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf
DE69303605D1 (de) Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung
KR950700913A (ko) 브릿지된 비스-아릴 카비놀 유도체, 조성물 및 사용방법(Bridged bis arylcarbinol derivatives, compositions and methods of use)
FI923759A0 (fi) Terapeutiska bensazapinfoereningar.
FI834800A0 (fi) Foerfarande foer framstaellning av dialkylaminoalkoxibensylalkohol-derivat
DE69103630D1 (de) Oxazolederivate, ihre herstellung und diese enthaltende pharmazeutischen zubereitungen.
DK0720598T3 (da) Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
NO971029L (no) Fremgangsmåter for hemming av endometriale metoser
IT1191109B (it) Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono
PT97885A (pt) Processo para a preparacao de derivados da {(1-aril-2-pirrolidinil)-metil-piperazina e de composicoes farmaceuticas que os contem
ATE96803T1 (de) Indolo(3,2,1-de>(1,4>-oxazino(2,3,4ij>(1,5>naphthyridinderivate, verfahren zu ihrer herstellung und zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
FI834789A0 (fi) Foerfarande foer framstaellning av 1,1-difenylpropanolderivat
SE8405332L (sv) 2h-azeto (2,1-a)-isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
ES481416A1 (es) Un procedimiento para la preparacion de un derivado monoami-da de acido tereftalico.
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.