ATE140960T1 - Verfahren zur herstellung von zellen, die stabil integrierte fremde dns mit hoher kopiezahl enthalten, durch dieses verfahren hergestellte zellen und verwendung dieser zellen zur herstellung von durch diese fremde dns kodierten polypeptiden - Google Patents

Verfahren zur herstellung von zellen, die stabil integrierte fremde dns mit hoher kopiezahl enthalten, durch dieses verfahren hergestellte zellen und verwendung dieser zellen zur herstellung von durch diese fremde dns kodierten polypeptiden

Info

Publication number
ATE140960T1
ATE140960T1 AT89303942T AT89303942T ATE140960T1 AT E140960 T1 ATE140960 T1 AT E140960T1 AT 89303942 T AT89303942 T AT 89303942T AT 89303942 T AT89303942 T AT 89303942T AT E140960 T1 ATE140960 T1 AT E140960T1
Authority
AT
Austria
Prior art keywords
cells
foreign dna
producing
copy number
stably integrated
Prior art date
Application number
AT89303942T
Other languages
English (en)
Inventor
James G Barsoum
Original Assignee
Btg Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22680067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE140960(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Btg Usa Inc filed Critical Btg Usa Inc
Application granted granted Critical
Publication of ATE140960T1 publication Critical patent/ATE140960T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT89303942T 1988-04-22 1989-04-20 Verfahren zur herstellung von zellen, die stabil integrierte fremde dns mit hoher kopiezahl enthalten, durch dieses verfahren hergestellte zellen und verwendung dieser zellen zur herstellung von durch diese fremde dns kodierten polypeptiden ATE140960T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/185,212 US4956288A (en) 1988-04-22 1988-04-22 Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA

Publications (1)

Publication Number Publication Date
ATE140960T1 true ATE140960T1 (de) 1996-08-15

Family

ID=22680067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89303942T ATE140960T1 (de) 1988-04-22 1989-04-20 Verfahren zur herstellung von zellen, die stabil integrierte fremde dns mit hoher kopiezahl enthalten, durch dieses verfahren hergestellte zellen und verwendung dieser zellen zur herstellung von durch diese fremde dns kodierten polypeptiden

Country Status (6)

Country Link
US (1) US4956288A (de)
EP (1) EP0343783B2 (de)
JP (1) JP2755421B2 (de)
AT (1) ATE140960T1 (de)
DE (1) DE68926892T3 (de)
ES (1) ES2092995T5 (de)

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DE68926892T2 (de) 1997-02-06
DE68926892T3 (de) 2000-11-09
DE68926892D1 (de) 1996-09-05
ES2092995T5 (es) 2000-08-16
JPH0284169A (ja) 1990-03-26
JP2755421B2 (ja) 1998-05-20
EP0343783B1 (de) 1996-07-31
EP0343783A3 (en) 1990-09-12
EP0343783A2 (de) 1989-11-29
US4956288A (en) 1990-09-11
EP0343783B2 (de) 2000-03-15

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