ATE141644T1 - Verfahren zur protein-n-myristoylation - Google Patents

Verfahren zur protein-n-myristoylation

Info

Publication number: ATE141644T1
Authority: AT; Austria
Prior art keywords: gene; myristoyltransferase; replication; coli; origin
Prior art date: 1990-02-26

Application number

AT91870031T

Other languages

English (en)

Inventor

Robert Joseph Duronio

Peter Olafs Olins

Jeffrey Ivan Gordon

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1991-02-25

Publication date

1996-09-15

1991-02-25 Application filed by Univ Washington filed Critical Univ Washington

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141644T1 publication Critical patent/ATE141644T1/de

Links

238000000034 method Methods 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 5
241000588724 Escherichia coli Species 0.000 abstract 2
108010016306 Glycylpeptide N-tetradecanoyltransferase Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
230000010076 replication Effects 0.000 abstract 2
101150023438 NMT gene Proteins 0.000 abstract 1
229960000723 ampicillin Drugs 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
230000009977 dual effect Effects 0.000 abstract 1
229930027917 kanamycin Natural products 0.000 abstract 1
229960000318 kanamycin Drugs 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
229930182823 kanamycin A Natural products 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229940105132 myristate Drugs 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
101150079601 recA gene Proteins 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

AT91870031T 1990-02-26 1991-02-25 Verfahren zur protein-n-myristoylation ATE141644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48510390A	1990-02-26	1990-02-26

Publications (1)

Publication Number	Publication Date
ATE141644T1 true ATE141644T1 (de)	1996-09-15

Family

ID=23926912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91870031T ATE141644T1 (de)	1990-02-26	1991-02-25	Verfahren zur protein-n-myristoylation

Country Status (9)

Country	Link
US (2)	US5436138A (de)
EP (1)	EP0445097B1 (de)
JP (1)	JPH06245775A (de)
AT (1)	ATE141644T1 (de)
CA (1)	CA2036965A1 (de)
DE (1)	DE69121435T2 (de)
DK (1)	DK0445097T3 (de)
ES (1)	ES2091903T3 (de)
GR (1)	GR3021484T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5942254A (en) *	1995-02-27	1999-08-24	Abbott Laboratories	Phosphorylated recombinant human β-casein expressed in a bacterial system
US5710044A (en) *	1995-02-27	1998-01-20	Abbott Laboratories	Plasmid for expressing phosphorylated recombinant proteins in a bacterial system
JPH11500920A (ja) *	1995-02-27	1999-01-26	アボツト・ラボラトリーズ	修飾された組換えタンパク質を細菌系において発現させるプラスミド
NZ304538A (en) *	1995-02-27	1999-08-30	Abbott Lab	Process for producing a modified recombinant protein in a host cell comprising preparing a single vector encoding both the exogenous protein and an enzyme capable of modifying the exogenous protein
US5807702A (en) *	1995-02-27	1998-09-15	Abbott Laboratories	Method for expressing phosphorylated recombinant human β-casein in a bacterial system
US5807700A (en) *	1995-11-27	1998-09-15	Washington University	Method of screening anti-amebic agents with an E. coli mutant having a deleted adhE gene complemented by the E. histolytica EhADH2 gene
AU7364098A (en) *	1997-04-30	1998-11-24	Trustees Of The University Of Pennsylvania, The	Bacterial interaction screening system
UA100692C2 (ru)	2007-05-02	2013-01-25	Мериал Лимитед	Днк-плазмиды, имеющие повышенную экспрессию и стабильность
WO2013172954A1 (en)	2012-05-17	2013-11-21	Ra Pharmaceuticals, Inc	Peptide and peptidomimetic inhibitors
WO2018157150A1 (en) *	2017-02-27	2018-08-30	Duke University	In vivo protein n-acylation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5013662A (en) *	1985-09-20	1991-05-07	Cetus Corporation	Bacterial methionine n-terminal peptidase
US4740588A (en) *	1986-08-07	1988-04-26	Washington University	Novel substrate peptides
US4709012A (en) *	1986-08-07	1987-11-24	Washington University	Novel inhibitor peptides
US4778878A (en) *	1986-08-07	1988-10-18	Washington University	Novel inhibitor peptides I
US4778877A (en) *	1986-08-07	1988-10-18	Washington University	Novel inhibitor peptides II
US4942130A (en) *	1987-01-14	1990-07-17	President & Fellows Of Harvard College	T7 DNA polymerase
US5073571A (en) *	1988-06-16	1991-12-17	Washington University	Method of inhibiting virus
US5082967A (en) *	1988-06-16	1992-01-21	Washington University	Novel fatty acid analog enzyme substrates
US5108919A (en) *	1988-06-24	1992-04-28	Genentech, Inc.	Dna sequences encoding yeast ubiquitin hydrolase

1991
- 1991-02-25 DE DE69121435T patent/DE69121435T2/de not_active Expired - Fee Related
- 1991-02-25 AT AT91870031T patent/ATE141644T1/de not_active IP Right Cessation
- 1991-02-25 CA CA002036965A patent/CA2036965A1/en not_active Abandoned
- 1991-02-25 EP EP91870031A patent/EP0445097B1/de not_active Expired - Lifetime
- 1991-02-25 DK DK91870031.1T patent/DK0445097T3/da active
- 1991-02-25 ES ES91870031T patent/ES2091903T3/es not_active Expired - Lifetime
- 1991-02-25 JP JP3030426A patent/JPH06245775A/ja active Pending
1993
- 1993-07-12 US US08/090,383 patent/US5436138A/en not_active Expired - Fee Related
1994
- 1994-07-13 US US08/274,606 patent/US5504008A/en not_active Expired - Fee Related
1996
- 1996-10-25 GR GR960402843T patent/GR3021484T3/el unknown

Also Published As

Publication number	Publication date
EP0445097A3 (en)	1992-01-08
GR3021484T3 (en)	1997-01-31
EP0445097B1 (de)	1996-08-21
JPH06245775A (ja)	1994-09-06
US5504008A (en)	1996-04-02
DK0445097T3 (da)	1996-09-16
US5436138A (en)	1995-07-25
EP0445097A2 (de)	1991-09-04
ES2091903T3 (es)	1996-11-16
CA2036965A1 (en)	1991-08-27
DE69121435T2 (de)	1997-02-27
DE69121435D1 (de)	1996-09-26

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Legal Events

Date	Code	Title	Description
1997-03-15	UEP	Publication of translation of european patent specification
1999-11-15	REN	Ceased due to non-payment of the annual fee