ATE143671T1 - Zyklisches polypeptid mit antibiotischer aktivität, dessen herstellung und reinkultur eines coelomycetes stammes - Google Patents

Zyklisches polypeptid mit antibiotischer aktivität, dessen herstellung und reinkultur eines coelomycetes stammes

Info

Publication number: ATE143671T1
Authority: AT; Austria
Prior art keywords: hydrogen; preparation; pure culture; alkoxy; chem
Prior art date: 1990-06-18

Application number

AT91109856T

Other languages

English (en)

Inventor

Iwamoto Toshiro

Fujie Akihiko

Nitta Kumiko

Tsurumi Yasuhisa

Shigematsu Nobuharu

Kasahara Chiyoshi

Hino Motohiro

Okuhara Masakuni

Sakane Kazuo

Kawabata Kohji

Ohki Hidenori

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-18

Filing date

1991-06-15

Publication date

1996-10-15

1990-06-18 Priority claimed from GB909013558A external-priority patent/GB9013558D0/en

1990-10-31 Priority claimed from GB909023666A external-priority patent/GB9023666D0/en

1991-01-24 Priority claimed from GB919101552A external-priority patent/GB9101552D0/en

1991-06-15 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1996-10-15 Application granted granted Critical

1996-10-15 Publication of ATE143671T1 publication Critical patent/ATE143671T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
230000003115 biocidal effect Effects 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
-1 hydroxysulfonyloxy Chemical group 0.000 abstract 2
229910006069 SO3H Inorganic materials 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Stringed Musical Instruments (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Materials For Medical Uses (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT91109856T 1990-06-18 1991-06-15 Zyklisches polypeptid mit antibiotischer aktivität, dessen herstellung und reinkultur eines coelomycetes stammes ATE143671T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB909013558A GB9013558D0 (en)	1990-06-18	1990-06-18	New polypeptide compound and a process for preparation thereof
GB909023666A GB9023666D0 (en)	1990-10-31	1990-10-31	Polypeptide compound and a process for preparation thereof
GB919101552A GB9101552D0 (en)	1991-01-24	1991-01-24	New polypeptide compound and a process for preparation thereof

Publications (1)

Publication Number	Publication Date
ATE143671T1 true ATE143671T1 (de)	1996-10-15

Family

ID=27265144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91109856T ATE143671T1 (de)	1990-06-18	1991-06-15	Zyklisches polypeptid mit antibiotischer aktivität, dessen herstellung und reinkultur eines coelomycetes stammes

Country Status (20)

Country	Link
US (1)	US5376634A (de)
EP (2)	EP0729974A1 (de)
JP (1)	JP3307410B2 (de)
KR (1)	KR100199535B1 (de)
CN (1)	CN1040541C (de)
AT (1)	ATE143671T1 (de)
AU (1)	AU651347B2 (de)
CA (1)	CA2044746C (de)
DE (1)	DE69122432T2 (de)
DK (1)	DK0462531T3 (de)
ES (1)	ES2093658T3 (de)
FI (1)	FI912873A7 (de)
GR (1)	GR3021780T3 (de)
HU (2)	HUT58108A (de)
IE (2)	IE990233A1 (de)
IL (1)	IL98506A (de)
NO (1)	NO912347L (de)
OA (1)	OA09369A (de)
PT (1)	PT98023B (de)
RU (1)	RU2108342C1 (de)

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* Cited by examiner, † Cited by third party
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GB8925593D0 (en) *	1989-11-13	1990-01-04	Fujisawa Pharmaceutical Co	Fr901379 substance and preparation thereof
US5330973A (en) *	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
US5386009A (en) *	1990-03-19	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
IE990233A1 (en)	1990-06-18	2000-11-15	Fujisawa Pharmaceutical Co	New Polypeptide Compound and a Process for Preparation thereof
US5428009A (en) *	1990-07-16	1995-06-27	Merck & Co., Inc.	Lipopeptide derivatives
USH1638H (en) *	1990-11-08	1997-03-04	Furuta; Takahisa	Use of the polypeptide compound
US5385884A (en) *	1991-08-27	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
US6743777B1 (en)	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) *	1992-03-19	1999-10-12	Eli Lilly And Company	Cyclic peptide antifungal agents
US6384013B1 (en)	1992-03-19	2002-05-07	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
CA2161149A1 (en) *	1993-05-04	1994-11-10	James M. Balkovec	Cyclohexapeptidyl aminoalkyl ethers
AU681119B2 (en) *	1993-05-17	1997-08-21	Fujisawa Pharmaceutical Co., Ltd.	New polypeptide compound and a process for preparation thereof
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WO1996011210A1 (en) *	1994-10-07	1996-04-18	Fujisawa Pharmaceutical Co., Ltd.	Cyclic hexapeptides having antibiotic activity
US5516756A (en) *	1994-10-31	1996-05-14	Merck & Co., Inc.	Aza cyclohexapeptide compounds
WO1996022784A1 (en) *	1995-01-26	1996-08-01	Merck & Co., Inc.	Novel antifungal cyclohexapeptides
US5646111A (en) *	1995-04-07	1997-07-08	Eli Lilly And Company	Cyclic peptide antifungal Agents
US5786325A (en) *	1995-05-26	1998-07-28	Eli Lilly And Company	Cyclic peptide antifungal agents and methods of making and using
US5629290A (en) *	1995-05-26	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
US5618787A (en) *	1995-05-26	1997-04-08	Eli Lilly And Company	Cyclic peptide antifungal agents
US5652213A (en) *	1995-05-26	1997-07-29	Eli Lilly And Company	Cyclic peptide antifungal agents
US5629289A (en) *	1995-07-25	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
EP1666587A1 (de)	1996-06-13	2006-06-07	Astellas Pharma Inc.	Zyclische lipopeptid acylase
AUPO371596A0 (en) *	1996-11-19	1996-12-12	Fujisawa Pharmaceutical Co., Ltd.	New compound
DE19728524A1 (de) *	1997-07-04	1999-01-07	Merck Patent Gmbh	Cyclische Azapeptide
JP3561917B2 (ja)	1998-02-09	2004-09-08	藤沢薬品工業株式会社	新規化合物
HUP0103714A3 (en) *	1998-05-11	2003-05-28	Takeda Pharmaceutical	Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity, medicaments containing them and their use
ES2233070T3 (es)	1998-08-20	2005-06-01	ELI LILLY & COMPANY	Sintesis de analogos peptidicos ciclicos modificados en el anillo.
DE69933046T2 (de)	1998-12-09	2007-09-13	Eli Lilly And Co., Indianapolis	Reinigung von echinocandin cyclopeptiden
KR20020003864A (ko)	1999-03-03	2002-01-15	피터 지. 스트링거	에키노칸딘/탄수화물 착물
AU767956B2 (en)	1999-03-03	2003-11-27	Eli Lilly And Company	Formation and anion-exchange of crystalline echinocandin ammonium salts
WO2000051567A1 (en)	1999-03-03	2000-09-08	Eli Lilly And Company	Processes for making pharmaceutical oral ecb formulations and compositions
EP1582204B1 (de)	1999-03-03	2013-09-25	Eli Lilly & Company	Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside
AUPP999799A0 (en)	1999-04-27	1999-05-20	Fujisawa Pharmaceutical Co., Ltd.	New compound
TWI233805B (en) *	1999-07-01	2005-06-11	Fujisawa Pharmaceutical Co	Stabilized pharmaceutical composition in lyophilized form as antifungal agent
CZ2002801A3 (cs) *	1999-09-03	2002-07-17	Sankyo Company Limited	Nové sloučeniny F-15078
EP1366065A1 (de) *	2001-02-26	2003-12-03	Fujisawa Pharmaceutical Co., Ltd.	Echinocandin-derivate, sie enthaltendende pharmazeutische zubereitungen und ihre verwendung als arzneimittel
KR20010098986A (ko) *	2001-07-27	2001-11-09	김종군	바르는 단열재(temp-coat)
US6991800B2 (en)	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products
US7459290B1 (en)	2004-03-30	2008-12-02	Iowa State University Research Foundation, Inc.	Methods of using functional 30S subunits
WO2010064219A1 (en)	2008-12-04	2010-06-10	Ranbaxy Laboratories Limited	Process for the preparation of a novel intermediate for caspofungin
RU2535489C1 (ru) *	2010-09-29	2014-12-10	Шанхай Техвелл Биофармасьютикал Ко., Лтд.	Способ очистки циклолипопептидных соединений или их солей
US8877777B2 (en) *	2010-09-30	2014-11-04	Shanghai Techwell Biopharmaceutical Co., Ltd.	Process for purifying cyclolipopeptide compounds or the salts thereof
CN102533551B (zh)	2010-12-15	2013-10-09	上海天伟生物制药有限公司	一种肽类抗生素的高产菌株及其制备方法和用途
CN102618604B (zh) *	2011-01-31	2014-09-03	上海天伟生物制药有限公司	一种环脂肽化合物的制备方法
BR112013026420A2 (pt)	2011-04-20	2020-11-03	Xellia Pharmaceuticals Aps	método de produção de um sal de micafungina farmaceuticamente aceitável
CN102659930B (zh) *	2012-03-30	2014-04-23	上海天伟生物制药有限公司	一种高纯度环肽类物质的晶体及其制备方法和用途
CN102627688B (zh)	2012-03-30	2014-12-31	上海天伟生物制药有限公司	一种高纯度环肽化合物及其制备方法和用途
CN102627689B (zh) *	2012-03-30	2014-08-06	上海天伟生物制药有限公司	一种环肽类化合物的水合物及其制备方法和用途
CN103387975A (zh)	2012-05-11	2013-11-13	上海天伟生物制药有限公司	一种固定化环脂肽酰基转移酶及其制备方法和用途
CN116987153A (zh) *	2023-07-31	2023-11-03	上海天伟生物制药有限公司	一种高纯度棘白菌素药物杂质及其制备方法和应用

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US4293489A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912A nucleus
CA1159450A (en) *	1979-12-13	1983-12-27	Manuel Debono	Process for the preparation of derivatives of cyclic peptide nuclei
US4293482A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	A-30912A Nucleus
CA1182812A (en) *	1979-12-13	1985-02-19	Bernard J. Abbott	Process for the preparation of derivatives of cyclic peptide nuclei
US4293488A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912B nucleus
US4293484A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912H nucleus
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
DE3886001T2 (de) *	1987-10-07	1994-05-26	Merck & Co Inc	Fungizides Fermentationsprodukt.
DK173802B1 (da) *	1988-09-12	2001-11-05	Merck & Co Inc	Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
EP0450048A4 (en) *	1989-10-18	1992-12-02	City Of Hope	Stable mammalian cell lines that express aromatase
GB8925593D0 (en) *	1989-11-13	1990-01-04	Fujisawa Pharmaceutical Co	Fr901379 substance and preparation thereof
US5386009A (en) *	1990-03-19	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
US5330973A (en) *	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
IE990233A1 (en)	1990-06-18	2000-11-15	Fujisawa Pharmaceutical Co	New Polypeptide Compound and a Process for Preparation thereof
EP0486011A3 (en) *	1990-11-16	1992-07-15	Fujisawa Pharmaceutical Co., Ltd.	Pharmaceutical composition against pneumocystis carinii

1991
- 1991-06-14 IE IE19990233A patent/IE990233A1/en unknown
- 1991-06-14 FI FI912873A patent/FI912873A7/fi not_active Application Discontinuation
- 1991-06-14 IE IE204691A patent/IE912046A1/en not_active IP Right Cessation
- 1991-06-14 IL IL9850691A patent/IL98506A/en not_active IP Right Cessation
- 1991-06-15 ES ES91109856T patent/ES2093658T3/es not_active Expired - Lifetime
- 1991-06-15 EP EP95117638A patent/EP0729974A1/de not_active Withdrawn
- 1991-06-15 EP EP91109856A patent/EP0462531B1/de not_active Expired - Lifetime
- 1991-06-15 DK DK91109856.4T patent/DK0462531T3/da active
- 1991-06-15 AT AT91109856T patent/ATE143671T1/de not_active IP Right Cessation
- 1991-06-15 DE DE69122432T patent/DE69122432T2/de not_active Expired - Lifetime
- 1991-06-17 US US07/715,961 patent/US5376634A/en not_active Expired - Lifetime
- 1991-06-17 HU HU912014A patent/HUT58108A/hu unknown
- 1991-06-17 NO NO91912347A patent/NO912347L/no unknown
- 1991-06-17 CA CA002044746A patent/CA2044746C/en not_active Expired - Lifetime
- 1991-06-17 RU SU4895760/04A patent/RU2108342C1/ru active
- 1991-06-17 AU AU78435/91A patent/AU651347B2/en not_active Expired
- 1991-06-18 OA OA60023A patent/OA09369A/xx unknown
- 1991-06-18 PT PT98023A patent/PT98023B/pt not_active IP Right Cessation
- 1991-06-18 JP JP24528491A patent/JP3307410B2/ja not_active Expired - Lifetime
- 1991-06-18 CN CN91104847A patent/CN1040541C/zh not_active Expired - Lifetime
- 1991-06-18 KR KR1019910010043A patent/KR100199535B1/ko not_active Expired - Lifetime
1995
- 1995-06-22 HU HU95P/P00349P patent/HU211740A9/hu unknown
1996
- 1996-11-27 GR GR960403178T patent/GR3021780T3/el unknown

Also Published As

Publication number	Publication date
ES2093658T3 (es)	1997-01-01
DE69122432T2 (de)	1997-03-20
KR920000788A (ko)	1992-01-29
JP3307410B2 (ja)	2002-07-24
GR3021780T3 (en)	1997-02-28
FI912873L (fi)	1991-12-19
IE912046A1 (en)	1991-12-18
IL98506A0 (en)	1992-07-15
CA2044746C (en)	2001-08-07
RU2108342C1 (ru)	1998-04-10
KR100199535B1 (ko)	1999-06-15
OA09369A (en)	1992-09-15
CN1059729A (zh)	1992-03-25
HU912014D0 (en)	1991-12-30
HU211740A9 (en)	1995-12-28
FI912873A7 (fi)	1991-12-19
CA2044746A1 (en)	1991-12-19
CN1040541C (zh)	1998-11-04
DE69122432D1 (de)	1996-11-07
AU7843591A (en)	1992-01-16
IL98506A (en)	1996-09-12
HUT58108A (en)	1992-01-28
AU651347B2 (en)	1994-07-21
IE990233A1 (en)	2000-11-15
DK0462531T3 (da)	1996-11-18
EP0462531B1 (de)	1996-10-02
EP0462531A2 (de)	1991-12-27
JPH04352799A (ja)	1992-12-07
US5376634A (en)	1994-12-27
NO912347L (no)	1991-12-19
FI912873A0 (fi)	1991-06-14
NO912347D0 (no)	1991-06-17
PT98023B (pt)	1998-11-30
PT98023A (pt)	1992-03-31
EP0729974A1 (de)	1996-09-04
EP0462531A3 (en)	1992-11-04

Legal Events

Date	Code	Title	Description
1997-04-15	UEP	Publication of translation of european patent specification
2011-09-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE143671T1 (de)	1996-10-15	Zyklisches polypeptid mit antibiotischer aktivität, dessen herstellung und reinkultur eines coelomycetes stammes
DE69021176D1 (de)	1995-08-31	Polypeptid und Verfahren zu dessen Herstellung.
NZ504203A (en)	2002-11-26	Pleuromutilin derivatives as antimicrobials
ATE194846T1 (de)	2000-08-15	Zyklische antimikrobielle peptide und deren herstellung
IE861820L (en)	1987-01-10	2-hydroxy-2-phenylethylaminotetralines
NZ238181A (en)	1993-02-25	N-(1-substituted-piperidinyl(alkyl))carbamic acid, urea and carboxamide derivatives and homologues thereof; preparatory processes and pharmaceutical compositions
AU6601294A (en)	1995-01-12	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
ATE61340T1 (de)	1991-03-15	Aminosaeurederivate und deren verfahren zur herstellung.
KR910016915A (ko)	1991-11-05	과콜레스테롤혈증 치료제
ATE138571T1 (de)	1996-06-15	Verwendung von dioxabicyclo (3.3.0>octane derivaten zur herstellung eines arzneimittels zur hemmung des cholesterinmetabolismus.
NO952402L (no)	1995-08-16	Substituerte 6-azaandrostenoner
ZA925093B (en)	1993-04-28	6-oxo-azepinoindol compounds as well as a process and intermediate products for the production thereof,and drugs that contain these compounds
MY111439A (en)	2000-05-31	Thymosin alpha 1 derivatives
HU198215B (en)	1989-08-28	Process for production of compositions similar in construction with antibiotics tan-749
FI860098A0 (fi)	1986-01-09	Nya piperazinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner som innehaoller dessa foereningar som aktiv ingrediens.
AU1032197A (en)	1997-06-19	New amino alcohol derivatives, processes for their production and pharmaceutical agents containing these compounds
AU2353595A (en)	1995-11-29	Antitumor indolopyprolocarbazole derivative
TW353071B (en)	1999-02-21	Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions
JPS6485973A (en)	1989-03-30	1,3-dithiol derivative
KR940002252A (ko)	1994-02-17	우수한 항균작용을 갖는 신규한 피리돈 카르복실산 유도체 및 그의 제조방법