DK0462531T3 - Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme - Google Patents

Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme

Info

Publication number: DK0462531T3
Authority: DK; Denmark
Prior art keywords: hydrogen; preparation; pure culture; alkoxy; chem
Prior art date: 1990-06-18

Application number

DK91109856.4T

Other languages

Danish (da)

English (en)

Inventor

Iwamoto Toshiro

Fujie Akihiko

Nitta Kumiko

Tsurumi Yasuhisa

Shigematsu Nobuharu

Kasahara Chiyoshi

Hino Motohiro

Okuhara Masakuni

Sakane Kazuo

Kawabata Kohji

Ohki Hidenori

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-18

Filing date

1991-06-15

Publication date

1996-11-18

1990-06-18 Priority claimed from GB909013558A external-priority patent/GB9013558D0/en

1990-10-31 Priority claimed from GB909023666A external-priority patent/GB9023666D0/en

1991-01-24 Priority claimed from GB919101552A external-priority patent/GB9101552D0/en

1991-06-15 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1996-11-18 Application granted granted Critical

1996-11-18 Publication of DK0462531T3 publication Critical patent/DK0462531T3/da

Links

229920001184 polypeptide Polymers 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
230000003115 biocidal effect Effects 0.000 title 1
125000004122 cyclic group Chemical group 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
-1 hydroxysulfonyloxy Chemical group 0.000 abstract 2
229910006069 SO3H Inorganic materials 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Stringed Musical Instruments (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Materials For Medical Uses (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK91109856.4T 1990-06-18 1991-06-15 Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme DK0462531T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB909013558A GB9013558D0 (en)	1990-06-18	1990-06-18	New polypeptide compound and a process for preparation thereof
GB909023666A GB9023666D0 (en)	1990-10-31	1990-10-31	Polypeptide compound and a process for preparation thereof
GB919101552A GB9101552D0 (en)	1991-01-24	1991-01-24	New polypeptide compound and a process for preparation thereof

Publications (1)

Publication Number	Publication Date
DK0462531T3 true DK0462531T3 (da)	1996-11-18

Family

ID=27265144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91109856.4T DK0462531T3 (da)	1990-06-18	1991-06-15	Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme

Country Status (20)

Country	Link
US (1)	US5376634A (de)
EP (2)	EP0462531B1 (de)
JP (1)	JP3307410B2 (de)
KR (1)	KR100199535B1 (de)
CN (1)	CN1040541C (de)
AT (1)	ATE143671T1 (de)
AU (1)	AU651347B2 (de)
CA (1)	CA2044746C (de)
DE (1)	DE69122432T2 (de)
DK (1)	DK0462531T3 (de)
ES (1)	ES2093658T3 (de)
FI (1)	FI912873L (de)
GR (1)	GR3021780T3 (de)
HU (2)	HUT58108A (de)
IE (2)	IE912046A1 (de)
IL (1)	IL98506A (de)
NO (1)	NO912347L (de)
OA (1)	OA09369A (de)
PT (1)	PT98023B (de)
RU (1)	RU2108342C1 (de)

Families Citing this family (51)

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GB8925593D0 (en) *	1989-11-13	1990-01-04	Fujisawa Pharmaceutical Co	Fr901379 substance and preparation thereof
US5330973A (en) *	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
US5386009A (en) *	1990-03-19	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
IL98506A (en)	1990-06-18	1996-09-12	Fujisawa Pharmaceutical Co	Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5428009A (en) *	1990-07-16	1995-06-27	Merck & Co., Inc.	Lipopeptide derivatives
USH1638H (en) *	1990-11-08	1997-03-04	Furuta; Takahisa	Use of the polypeptide compound
US5385884A (en) *	1991-08-27	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
US6743777B1 (en)	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en)	1992-03-19	2002-05-07	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) *	1992-03-19	1999-10-12	Eli Lilly And Company	Cyclic peptide antifungal agents
JPH09500103A (ja) *	1993-05-04	1997-01-07	メルクエンドカンパニーインコーポレーテッド	シクロヘキサペプチジルアミノアルキルエーテル
IL109615A (en) *	1993-05-17	2000-12-06	Fujisawa Pharmaceutical Co	Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
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RU2165423C2 (ru) *	1994-10-07	2001-04-20	Фудзисава Фармасьютикал Ко., Лтд.	Полипептидное соединение, способ его получения и фармацевтическая композиция
US5516756A (en) *	1994-10-31	1996-05-14	Merck & Co., Inc.	Aza cyclohexapeptide compounds
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US5646111A (en) *	1995-04-07	1997-07-08	Eli Lilly And Company	Cyclic peptide antifungal Agents
US5786325A (en) *	1995-05-26	1998-07-28	Eli Lilly And Company	Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) *	1995-05-26	1997-07-29	Eli Lilly And Company	Cyclic peptide antifungal agents
US5629290A (en) *	1995-05-26	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
US5618787A (en) *	1995-05-26	1997-04-08	Eli Lilly And Company	Cyclic peptide antifungal agents
US5629289A (en) *	1995-07-25	1997-05-13	Eli Lilly And Company	Cyclic peptide antifungal agents
EP0933422A4 (de) *	1996-06-13	2005-02-02	Fujisawa Pharmaceutical Co	Zyclische lipopeptid acylase
AUPO371596A0 (en) *	1996-11-19	1996-12-12	Fujisawa Pharmaceutical Co., Ltd.	New compound
DE19728524A1 (de) *	1997-07-04	1999-01-07	Merck Patent Gmbh	Cyclische Azapeptide
CN1240713C (zh)	1998-02-09	2006-02-08	藤泽药品工业株式会社	化合物
IL139470A0 (en) *	1998-05-11	2001-11-25	Takeda Chemical Industries Ltd	Oxyiminoalkanoic acid derivatives
ATE287899T1 (de)	1998-08-20	2005-02-15	Lilly Co Eli	Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
DK1137663T3 (da)	1998-12-09	2007-01-08	Lilly Co Eli	Oprensning af Echinocandin-cyclopeptidforbindelser
ATE248187T1 (de)	1999-03-03	2003-09-15	Lilly Co Eli	Echinocandin-kohlenhydrate-komplexe
AU767956B2 (en)	1999-03-03	2003-11-27	Eli Lilly And Company	Formation and anion-exchange of crystalline echinocandin ammonium salts
HK1040062A1 (zh)	1999-03-03	2002-05-24	Eli Lilly And Company	含有成胶束表面活性剂的棘白菌素药物配方
HK1040369A1 (zh)	1999-03-03	2002-06-07	Eli Lilly And Company	制备药物口服ecb配方和组合物的方法
AUPP999799A0 (en)	1999-04-27	1999-05-20	Fujisawa Pharmaceutical Co., Ltd.	New compound
TWI233805B (en) *	1999-07-01	2005-06-11	Fujisawa Pharmaceutical Co	Stabilized pharmaceutical composition in lyophilized form as antifungal agent
NZ517561A (en) *	1999-09-03	2003-06-30	Sankyo Co	Nacrocyclic compounds formed by the fermentation of a Phoma sp. strain
JP2004524318A (ja) *	2001-02-26	2004-08-12	藤沢薬品工業株式会社	エチノカンジン誘導体およびその医薬組成物および医薬としての用途
KR20010098986A (ko) *	2001-07-27	2001-11-09	김종군	바르는 단열재(temp-coat)
US6991800B2 (en)	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products
US7459290B1 (en)	2004-03-30	2008-12-02	Iowa State University Research Foundation, Inc.	Methods of using functional 30S subunits
WO2010064219A1 (en)	2008-12-04	2010-06-10	Ranbaxy Laboratories Limited	Process for the preparation of a novel intermediate for caspofungin
ES2581562T3 (es)	2010-09-29	2016-09-06	Shanghai Techwell Biopharmaceutical Co., Ltd	Procedimiento para purificar compuestos lipopeptídicos cíclicos o sales de los mismos
CN102443050B (zh) *	2010-09-30	2014-06-04	上海天伟生物制药有限公司	一种环脂肽化合物或其盐的纯化方法
CN102533551B (zh) *	2010-12-15	2013-10-09	上海天伟生物制药有限公司	一种肽类抗生素的高产菌株及其制备方法和用途
CN102618604B (zh) *	2011-01-31	2014-09-03	上海天伟生物制药有限公司	一种环脂肽化合物的制备方法
WO2012143293A1 (en)	2011-04-20	2012-10-26	Xellia Pharmaceuticals Aps	Method for purification of micafungin
CN102627688B (zh)	2012-03-30	2014-12-31	上海天伟生物制药有限公司	一种高纯度环肽化合物及其制备方法和用途
CN102627689B (zh) *	2012-03-30	2014-08-06	上海天伟生物制药有限公司	一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) *	2012-03-30	2014-04-23	上海天伟生物制药有限公司	一种高纯度环肽类物质的晶体及其制备方法和用途
CN103387975A (zh)	2012-05-11	2013-11-13	上海天伟生物制药有限公司	一种固定化环脂肽酰基转移酶及其制备方法和用途
CN116987153A (zh) *	2023-07-31	2023-11-03	上海天伟生物制药有限公司	一种高纯度棘白菌素药物杂质及其制备方法和应用

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US4293482A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	A-30912A Nucleus
CA1182812A (en) *	1979-12-13	1985-02-19	Bernard J. Abbott	Process for the preparation of derivatives of cyclic peptide nuclei
US4293489A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912A nucleus
CA1159450A (en) *	1979-12-13	1983-12-27	Manuel Debono	Process for the preparation of derivatives of cyclic peptide nuclei
US4293484A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912H nucleus
US4293488A (en) *	1979-12-13	1981-10-06	Eli Lilly And Company	Derivatives of A-30912B nucleus
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
EP0311193B1 (de) *	1987-10-07	1993-12-01	Merck & Co. Inc.	Fungizides Fermentationsprodukt
DK173802B1 (da) *	1988-09-12	2001-11-05	Merck & Co Inc	Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
EP0450048A4 (en) *	1989-10-18	1992-12-02	City Of Hope	Stable mammalian cell lines that express aromatase
GB8925593D0 (en) *	1989-11-13	1990-01-04	Fujisawa Pharmaceutical Co	Fr901379 substance and preparation thereof
US5386009A (en) *	1990-03-19	1995-01-31	Merck & Co. Inc.	Lipopeptide derivatives
US5330973A (en) *	1990-03-19	1994-07-19	Merck & Co., Inc.	Lipopeptide derivatives
IL98506A (en)	1990-06-18	1996-09-12	Fujisawa Pharmaceutical Co	Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
EP0486011A3 (en) *	1990-11-16	1992-07-15	Fujisawa Pharmaceutical Co., Ltd.	Pharmaceutical composition against pneumocystis carinii

1991
- 1991-06-14 IL IL9850691A patent/IL98506A/en not_active IP Right Cessation
- 1991-06-14 FI FI912873A patent/FI912873L/fi not_active Application Discontinuation
- 1991-06-14 IE IE204691A patent/IE912046A1/en not_active IP Right Cessation
- 1991-06-14 IE IE19990233A patent/IE990233A1/en unknown
- 1991-06-15 EP EP91109856A patent/EP0462531B1/de not_active Expired - Lifetime
- 1991-06-15 DE DE69122432T patent/DE69122432T2/de not_active Expired - Lifetime
- 1991-06-15 ES ES91109856T patent/ES2093658T3/es not_active Expired - Lifetime
- 1991-06-15 DK DK91109856.4T patent/DK0462531T3/da active
- 1991-06-15 AT AT91109856T patent/ATE143671T1/de not_active IP Right Cessation
- 1991-06-15 EP EP95117638A patent/EP0729974A1/de not_active Withdrawn
- 1991-06-17 AU AU78435/91A patent/AU651347B2/en not_active Expired
- 1991-06-17 RU SU4895760/04A patent/RU2108342C1/ru active
- 1991-06-17 CA CA002044746A patent/CA2044746C/en not_active Expired - Lifetime
- 1991-06-17 US US07/715,961 patent/US5376634A/en not_active Expired - Lifetime
- 1991-06-17 HU HU912014A patent/HUT58108A/hu unknown
- 1991-06-17 NO NO91912347A patent/NO912347L/no unknown
- 1991-06-18 CN CN91104847A patent/CN1040541C/zh not_active Expired - Lifetime
- 1991-06-18 PT PT98023A patent/PT98023B/pt not_active IP Right Cessation
- 1991-06-18 OA OA60023A patent/OA09369A/xx unknown
- 1991-06-18 JP JP24528491A patent/JP3307410B2/ja not_active Expired - Lifetime
- 1991-06-18 KR KR1019910010043A patent/KR100199535B1/ko not_active Expired - Lifetime
1995
- 1995-06-22 HU HU95P/P00349P patent/HU211740A9/hu unknown
1996
- 1996-11-27 GR GR960403178T patent/GR3021780T3/el unknown

Also Published As

Publication number	Publication date
EP0729974A1 (de)	1996-09-04
OA09369A (en)	1992-09-15
PT98023B (pt)	1998-11-30
IL98506A (en)	1996-09-12
RU2108342C1 (ru)	1998-04-10
CN1040541C (zh)	1998-11-04
FI912873A0 (fi)	1991-06-14
EP0462531B1 (de)	1996-10-02
GR3021780T3 (en)	1997-02-28
EP0462531A2 (de)	1991-12-27
NO912347D0 (no)	1991-06-17
PT98023A (pt)	1992-03-31
HU912014D0 (en)	1991-12-30
IE990233A1 (en)	2000-11-15
JPH04352799A (ja)	1992-12-07
DE69122432T2 (de)	1997-03-20
DE69122432D1 (de)	1996-11-07
AU651347B2 (en)	1994-07-21
CA2044746C (en)	2001-08-07
CN1059729A (zh)	1992-03-25
HU211740A9 (en)	1995-12-28
FI912873A7 (fi)	1991-12-19
KR100199535B1 (ko)	1999-06-15
ATE143671T1 (de)	1996-10-15
HUT58108A (en)	1992-01-28
FI912873L (fi)	1991-12-19
AU7843591A (en)	1992-01-16
JP3307410B2 (ja)	2002-07-24
CA2044746A1 (en)	1991-12-19
ES2093658T3 (es)	1997-01-01
KR920000788A (ko)	1992-01-29
EP0462531A3 (en)	1992-11-04
NO912347L (no)	1991-12-19
IL98506A0 (en)	1992-07-15
US5376634A (en)	1994-12-27
IE912046A1 (en)	1991-12-18

Publication	Publication Date	Title
DK0462531T3 (da)	1996-11-18	Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme
DE69021176D1 (de)	1995-08-31	Polypeptid und Verfahren zu dessen Herstellung.
MY107319A (en)	1995-11-30	Process for the preparation of cyclic amino acids, as well as intermediates.
MY121760A (en)	2006-02-28	Benzothiazin and benzoxazin derivatives;their preparation and uses
NZ504203A (en)	2002-11-26	Pleuromutilin derivatives as antimicrobials
NZ237132A (en)	1993-04-28	Preparation of substituted oxetanones from beta-hydroxy-omega-lactones; various beta-hydroxy and beta-keto-omega-lactones
HUT68385A (en)	1995-06-28	Polypeptide and process for producing thereof
GB8819024D0 (en)	1988-09-14	Chemical compounds
PT82134B (en)	1987-08-10	Process for the preparation of amino acid derivatives comprising the culturing of fr-900490 producing strain belonging to the genus discosia
ES2000368A6 (es)	1988-02-16	Un procedimiento para preparar di-t-butilfenoles sustituidos
MY111439A (en)	2000-05-31	Thymosin alpha 1 derivatives
GB8903036D0 (en)	1989-03-30	Chemical compounds
HU198215B (en)	1989-08-28	Process for production of compositions similar in construction with antibiotics tan-749
ES8704895A1 (es)	1987-04-16	Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas
NZ332245A (en)	2000-03-27	Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
AU7020996A (en)	1997-04-24	UCK14 compounds
UA42798C2 (uk)	2001-11-15	Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, проміжні сполуки, фармацевтична композиція на основі аналогів 15-дезоксипергуаліну
CA1261341A (en)	1989-09-26	SPIRO[BENZOFURANE-2(3H),1'-CYCLOHEPTANES]; METHOD AND INTERMEDIATE PRODUCTS FOR PREPARING THEM; THEIR USE AS MEDICINES
GR3021336T3 (en)	1997-01-31	New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof.