ES2093658T3 - Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes. - Google Patents

Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes.

Info

Publication number
ES2093658T3
ES2093658T3 ES91109856T ES91109856T ES2093658T3 ES 2093658 T3 ES2093658 T3 ES 2093658T3 ES 91109856 T ES91109856 T ES 91109856T ES 91109856 T ES91109856 T ES 91109856T ES 2093658 T3 ES2093658 T3 ES 2093658T3
Authority
ES
Spain
Prior art keywords
elevado
elevated
alcoxi
preparation
superior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91109856T
Other languages
English (en)
Inventor
Iwamoto Toshiro
Fujie Akihiko
Nitta Kumiko
Tsurumi Yasuhisa
Shigematsu Nobuharu
Kasahara Chiyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909013558A external-priority patent/GB9013558D0/en
Priority claimed from GB909023666A external-priority patent/GB9023666D0/en
Priority claimed from GB919101552A external-priority patent/GB9101552D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2093658T3 publication Critical patent/ES2093658T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Stringed Musical Instruments (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

UN COMPUESTO POLIPEPTIDO DE LA SIGUIENTE FORMULA GENERAL: DONDE R ELEVADO 1 ES HIDROGENO O UN GRUPO ACILO, R (AL CUADRADO) ES HIDROXI O ACILOXI, R ELEVADO 3 ES HIDROGENO O HIDROXISULFONILOXI, Y R ELEVADO 4 ES HIDROGENO O CARBAMOILO, CON LA SALVEDAD DE QUE (I) R (AL CUADRADO) ES ACILOXI, DONDE R ELEVADO 3 ES HIDROGENO, Y (II) R ELEVADO 1 NO ES PALMITOILO, CUANDO R (AL CUADRADO) ES HIDROXI, R ELEVADO 3 ES HIDROXISULFONILOXI Y R ELEVADO 4 ES CARBAMOILO, Y SU SAL FARMACEUTICAMENTE ACEPTABLE, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN. LA INVENCION TAMBIEN SE REFIERE A INTERMEDIARIOS DE LA FORMULA DONDE R ELEVADO 6 ES ALCOXI (C SUB 4-C SUB 6), ALCOXI SUPERIOR O ALQUENILOXI SUPERIOR, Y R ELEVADO 7 ES -COOH O -SO SUB 3H, O SU DERIVADO REACTIVO EN EL GRUPO CARBOXI O UNA DE SUS SALES Y DONDE R ELEVADO 8 ES HALOGENO DE 1 A 4, Y R ELEVADO 9 ES ALCOXI INFERIOR QUE TIENE UNO O MAS DE HALOGENO, ALCOXI SUPERIOR QUE TIENE UNO O MAS DE HALOGENO, O SU DERIVADO REACTIVO EN EL GRUPO CARBOXI O, UNA DE SUS SALES. LA INVENCION TAMBIEN SE REFIERE A UN CULTIVO BIOLOGICAMENTE PURO DE LA CEPA DEL MICROORGANISMO COLONICETO F -11899(FERM BP-2635).
ES91109856T 1990-06-18 1991-06-15 Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes. Expired - Lifetime ES2093658T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909013558A GB9013558D0 (en) 1990-06-18 1990-06-18 New polypeptide compound and a process for preparation thereof
GB909023666A GB9023666D0 (en) 1990-10-31 1990-10-31 Polypeptide compound and a process for preparation thereof
GB919101552A GB9101552D0 (en) 1991-01-24 1991-01-24 New polypeptide compound and a process for preparation thereof

Publications (1)

Publication Number Publication Date
ES2093658T3 true ES2093658T3 (es) 1997-01-01

Family

ID=27265144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91109856T Expired - Lifetime ES2093658T3 (es) 1990-06-18 1991-06-15 Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes.

Country Status (20)

Country Link
US (1) US5376634A (es)
EP (2) EP0462531B1 (es)
JP (1) JP3307410B2 (es)
KR (1) KR100199535B1 (es)
CN (1) CN1040541C (es)
AT (1) ATE143671T1 (es)
AU (1) AU651347B2 (es)
CA (1) CA2044746C (es)
DE (1) DE69122432T2 (es)
DK (1) DK0462531T3 (es)
ES (1) ES2093658T3 (es)
FI (1) FI912873L (es)
GR (1) GR3021780T3 (es)
HU (2) HUT58108A (es)
IE (2) IE912046A1 (es)
IL (1) IL98506A (es)
NO (1) NO912347L (es)
OA (1) OA09369A (es)
PT (1) PT98023B (es)
RU (1) RU2108342C1 (es)

Families Citing this family (51)

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GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5428009A (en) * 1990-07-16 1995-06-27 Merck & Co., Inc. Lipopeptide derivatives
USH1638H (en) * 1990-11-08 1997-03-04 Furuta; Takahisa Use of the polypeptide compound
US5385884A (en) * 1991-08-27 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
JPH09500103A (ja) * 1993-05-04 1997-01-07 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルアミノアルキルエーテル
IL109615A (en) * 1993-05-17 2000-12-06 Fujisawa Pharmaceutical Co Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
RU2165423C2 (ru) * 1994-10-07 2001-04-20 Фудзисава Фармасьютикал Ко., Лтд. Полипептидное соединение, способ его получения и фармацевтическая композиция
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
WO1996022784A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5786325A (en) * 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) * 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) * 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) * 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0933422A4 (en) * 1996-06-13 2005-02-02 Fujisawa Pharmaceutical Co CYCLIC LIPOPEPTIDE ACYLASE
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
DE19728524A1 (de) * 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
CN1240713C (zh) 1998-02-09 2006-02-08 藤泽药品工业株式会社 化合物
IL139470A0 (en) * 1998-05-11 2001-11-25 Takeda Chemical Industries Ltd Oxyiminoalkanoic acid derivatives
ATE287899T1 (de) 1998-08-20 2005-02-15 Lilly Co Eli Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
DK1137663T3 (da) 1998-12-09 2007-01-08 Lilly Co Eli Oprensning af Echinocandin-cyclopeptidforbindelser
ATE248187T1 (de) 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
AU767956B2 (en) 1999-03-03 2003-11-27 Eli Lilly And Company Formation and anion-exchange of crystalline echinocandin ammonium salts
HK1040062A1 (zh) 1999-03-03 2002-05-24 Eli Lilly And Company 含有成胶束表面活性剂的棘白菌素药物配方
HK1040369A1 (zh) 1999-03-03 2002-06-07 Eli Lilly And Company 制备药物口服ecb配方和组合物的方法
AUPP999799A0 (en) 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
NZ517561A (en) * 1999-09-03 2003-06-30 Sankyo Co Nacrocyclic compounds formed by the fermentation of a Phoma sp. strain
JP2004524318A (ja) * 2001-02-26 2004-08-12 藤沢薬品工業株式会社 エチノカンジン誘導体およびその医薬組成物および医薬としての用途
KR20010098986A (ko) * 2001-07-27 2001-11-09 김종군 바르는 단열재(temp-coat)
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US7459290B1 (en) 2004-03-30 2008-12-02 Iowa State University Research Foundation, Inc. Methods of using functional 30S subunits
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
ES2581562T3 (es) 2010-09-29 2016-09-06 Shanghai Techwell Biopharmaceutical Co., Ltd Procedimiento para purificar compuestos lipopeptídicos cíclicos o sales de los mismos
CN102443050B (zh) * 2010-09-30 2014-06-04 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
CN102533551B (zh) * 2010-12-15 2013-10-09 上海天伟生物制药有限公司 一种肽类抗生素的高产菌株及其制备方法和用途
CN102618604B (zh) * 2011-01-31 2014-09-03 上海天伟生物制药有限公司 一种环脂肽化合物的制备方法
WO2012143293A1 (en) 2011-04-20 2012-10-26 Xellia Pharmaceuticals Aps Method for purification of micafungin
CN102627688B (zh) 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) * 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN103387975A (zh) 2012-05-11 2013-11-13 上海天伟生物制药有限公司 一种固定化环脂肽酰基转移酶及其制备方法和用途
CN116987153A (zh) * 2023-07-31 2023-11-03 上海天伟生物制药有限公司 一种高纯度棘白菌素药物杂质及其制备方法和应用

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US4293482A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
CA1182812A (en) * 1979-12-13 1985-02-19 Bernard J. Abbott Process for the preparation of derivatives of cyclic peptide nuclei
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
CA1159450A (en) * 1979-12-13 1983-12-27 Manuel Debono Process for the preparation of derivatives of cyclic peptide nuclei
US4293484A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912H nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
EP0311193B1 (en) * 1987-10-07 1993-12-01 Merck & Co. Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
EP0450048A4 (en) * 1989-10-18 1992-12-02 City Of Hope Stable mammalian cell lines that express aromatase
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
EP0729974A1 (en) 1996-09-04
OA09369A (en) 1992-09-15
PT98023B (pt) 1998-11-30
IL98506A (en) 1996-09-12
RU2108342C1 (ru) 1998-04-10
CN1040541C (zh) 1998-11-04
FI912873A0 (fi) 1991-06-14
EP0462531B1 (en) 1996-10-02
GR3021780T3 (en) 1997-02-28
EP0462531A2 (en) 1991-12-27
NO912347D0 (no) 1991-06-17
PT98023A (pt) 1992-03-31
HU912014D0 (en) 1991-12-30
IE990233A1 (en) 2000-11-15
JPH04352799A (ja) 1992-12-07
DE69122432T2 (de) 1997-03-20
DE69122432D1 (de) 1996-11-07
DK0462531T3 (da) 1996-11-18
AU651347B2 (en) 1994-07-21
CA2044746C (en) 2001-08-07
CN1059729A (zh) 1992-03-25
HU211740A9 (en) 1995-12-28
FI912873A7 (fi) 1991-12-19
KR100199535B1 (ko) 1999-06-15
ATE143671T1 (de) 1996-10-15
HUT58108A (en) 1992-01-28
FI912873L (fi) 1991-12-19
AU7843591A (en) 1992-01-16
JP3307410B2 (ja) 2002-07-24
CA2044746A1 (en) 1991-12-19
KR920000788A (ko) 1992-01-29
EP0462531A3 (en) 1992-11-04
NO912347L (no) 1991-12-19
IL98506A0 (en) 1992-07-15
US5376634A (en) 1994-12-27
IE912046A1 (en) 1991-12-18

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