ES2093658T3 - Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes. - Google Patents

Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes.

Info

Publication number
ES2093658T3
ES2093658T3 ES91109856T ES91109856T ES2093658T3 ES 2093658 T3 ES2093658 T3 ES 2093658T3 ES 91109856 T ES91109856 T ES 91109856T ES 91109856 T ES91109856 T ES 91109856T ES 2093658 T3 ES2093658 T3 ES 2093658T3
Authority
ES
Spain
Prior art keywords
elevado
elevated
alcoxi
preparation
superior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91109856T
Other languages
English (en)
Inventor
Iwamoto Toshiro
Fujie Akihiko
Nitta Kumiko
Tsurumi Yasuhisa
Shigematsu Nobuharu
Kasahara Chiyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909013558A external-priority patent/GB9013558D0/en
Priority claimed from GB909023666A external-priority patent/GB9023666D0/en
Priority claimed from GB919101552A external-priority patent/GB9101552D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2093658T3 publication Critical patent/ES2093658T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Stringed Musical Instruments (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN COMPUESTO POLIPEPTIDO DE LA SIGUIENTE FORMULA GENERAL: DONDE R ELEVADO 1 ES HIDROGENO O UN GRUPO ACILO, R (AL CUADRADO) ES HIDROXI O ACILOXI, R ELEVADO 3 ES HIDROGENO O HIDROXISULFONILOXI, Y R ELEVADO 4 ES HIDROGENO O CARBAMOILO, CON LA SALVEDAD DE QUE (I) R (AL CUADRADO) ES ACILOXI, DONDE R ELEVADO 3 ES HIDROGENO, Y (II) R ELEVADO 1 NO ES PALMITOILO, CUANDO R (AL CUADRADO) ES HIDROXI, R ELEVADO 3 ES HIDROXISULFONILOXI Y R ELEVADO 4 ES CARBAMOILO, Y SU SAL FARMACEUTICAMENTE ACEPTABLE, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN. LA INVENCION TAMBIEN SE REFIERE A INTERMEDIARIOS DE LA FORMULA DONDE R ELEVADO 6 ES ALCOXI (C SUB 4-C SUB 6), ALCOXI SUPERIOR O ALQUENILOXI SUPERIOR, Y R ELEVADO 7 ES -COOH O -SO SUB 3H, O SU DERIVADO REACTIVO EN EL GRUPO CARBOXI O UNA DE SUS SALES Y DONDE R ELEVADO 8 ES HALOGENO DE 1 A 4, Y R ELEVADO 9 ES ALCOXI INFERIOR QUE TIENE UNO O MAS DE HALOGENO, ALCOXI SUPERIOR QUE TIENE UNO O MAS DE HALOGENO, O SU DERIVADO REACTIVO EN EL GRUPO CARBOXI O, UNA DE SUS SALES. LA INVENCION TAMBIEN SE REFIERE A UN CULTIVO BIOLOGICAMENTE PURO DE LA CEPA DEL MICROORGANISMO COLONICETO F -11899(FERM BP-2635).
ES91109856T 1990-06-18 1991-06-15 Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes. Expired - Lifetime ES2093658T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909013558A GB9013558D0 (en) 1990-06-18 1990-06-18 New polypeptide compound and a process for preparation thereof
GB909023666A GB9023666D0 (en) 1990-10-31 1990-10-31 Polypeptide compound and a process for preparation thereof
GB919101552A GB9101552D0 (en) 1991-01-24 1991-01-24 New polypeptide compound and a process for preparation thereof

Publications (1)

Publication Number Publication Date
ES2093658T3 true ES2093658T3 (es) 1997-01-01

Family

ID=27265144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91109856T Expired - Lifetime ES2093658T3 (es) 1990-06-18 1991-06-15 Polipeptido ciclico con actividad antibiotica, procedimiento para su preparacion y cultivo puro de una cepa de coelomycetes.

Country Status (20)

Country Link
US (1) US5376634A (es)
EP (2) EP0729974A1 (es)
JP (1) JP3307410B2 (es)
KR (1) KR100199535B1 (es)
CN (1) CN1040541C (es)
AT (1) ATE143671T1 (es)
AU (1) AU651347B2 (es)
CA (1) CA2044746C (es)
DE (1) DE69122432T2 (es)
DK (1) DK0462531T3 (es)
ES (1) ES2093658T3 (es)
FI (1) FI912873L (es)
GR (1) GR3021780T3 (es)
HU (2) HUT58108A (es)
IE (2) IE912046A1 (es)
IL (1) IL98506A (es)
NO (1) NO912347L (es)
OA (1) OA09369A (es)
PT (1) PT98023B (es)
RU (1) RU2108342C1 (es)

Families Citing this family (51)

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GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5428009A (en) * 1990-07-16 1995-06-27 Merck & Co., Inc. Lipopeptide derivatives
USH1638H (en) * 1990-11-08 1997-03-04 Furuta; Takahisa Use of the polypeptide compound
US5385884A (en) * 1991-08-27 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
CA2161149A1 (en) * 1993-05-04 1994-11-10 James M. Balkovec Cyclohexapeptidyl aminoalkyl ethers
AU681119B2 (en) * 1993-05-17 1997-08-21 Fujisawa Pharmaceutical Co., Ltd. New polypeptide compound and a process for preparation thereof
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
WO1996011210A1 (en) * 1994-10-07 1996-04-18 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2211138A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5786325A (en) * 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629290A (en) * 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) * 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) * 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0933422A4 (en) 1996-06-13 2005-02-02 Fujisawa Pharmaceutical Co CYCLIC LIPOPEPTIDE ACYLASE
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
DE19728524A1 (de) * 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
WO1999040108A1 (en) 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
ES2226377T3 (es) * 1998-05-11 2005-03-16 Takeda Chemical Industries, Ltd. Derivados de acido oxiimino-alcalino con actividad hipoglucemica e hipolipidemica.
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
IL143563A0 (en) 1998-12-09 2002-04-21 Lilly Co Eli Purification of echinocandin cyclopeptide compounds
BR0009248A (pt) 1999-03-03 2001-11-20 Lilly Co Eli Formação e troca de ânion de sais de amÈnioequinocandina cristalinos
ATE294571T1 (de) 1999-03-03 2005-05-15 Lilly Co Eli Echinocandin pharmazeutische zusammensetzungen
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
AUPP999799A0 (en) 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
WO2001018227A1 (en) * 1999-09-03 2001-03-15 Sankyo Company, Limited Novel compound f-15078
JP2004524318A (ja) * 2001-02-26 2004-08-12 藤沢薬品工業株式会社 エチノカンジン誘導体およびその医薬組成物および医薬としての用途
KR20010098986A (ko) * 2001-07-27 2001-11-09 김종군 바르는 단열재(temp-coat)
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US7459290B1 (en) 2004-03-30 2008-12-02 Iowa State University Research Foundation, Inc. Methods of using functional 30S subunits
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
CN102432674B (zh) * 2010-09-29 2014-01-22 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
EP2623611B1 (en) * 2010-09-30 2016-07-13 Shanghai Techwell Biopharmaceutical Co., Ltd Method for purifying cyclic lipopeptide or salt thereof
CN102533551B (zh) 2010-12-15 2013-10-09 上海天伟生物制药有限公司 一种肽类抗生素的高产菌株及其制备方法和用途
CN102618604B (zh) * 2011-01-31 2014-09-03 上海天伟生物制药有限公司 一种环脂肽化合物的制备方法
HUE027806T2 (en) 2011-04-20 2016-11-28 Xellia Pharmaceuticals Aps A method for purifying micafungin
CN102627688B (zh) * 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) * 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN103387975A (zh) 2012-05-11 2013-11-13 上海天伟生物制药有限公司 一种固定化环脂肽酰基转移酶及其制备方法和用途
CN116987153A (zh) * 2023-07-31 2023-11-03 上海天伟生物制药有限公司 一种高纯度棘白菌素药物杂质及其制备方法和应用

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US4293482A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
CA1182812A (en) * 1979-12-13 1985-02-19 Bernard J. Abbott Process for the preparation of derivatives of cyclic peptide nuclei
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293484A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912H nucleus
CA1159450A (en) * 1979-12-13 1983-12-27 Manuel Debono Process for the preparation of derivatives of cyclic peptide nuclei
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
DE3886001T2 (de) * 1987-10-07 1994-05-26 Merck & Co Inc Fungizides Fermentationsprodukt.
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
WO1991005794A1 (en) * 1989-10-18 1991-05-02 City Of Hope Stable mammalian cell lines that express aromatase
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
DE69122432D1 (de) 1996-11-07
PT98023A (pt) 1992-03-31
HUT58108A (en) 1992-01-28
FI912873A7 (fi) 1991-12-19
EP0462531A2 (en) 1991-12-27
HU912014D0 (en) 1991-12-30
HU211740A9 (en) 1995-12-28
EP0729974A1 (en) 1996-09-04
IL98506A0 (en) 1992-07-15
KR100199535B1 (ko) 1999-06-15
EP0462531A3 (en) 1992-11-04
CA2044746C (en) 2001-08-07
JPH04352799A (ja) 1992-12-07
CA2044746A1 (en) 1991-12-19
US5376634A (en) 1994-12-27
KR920000788A (ko) 1992-01-29
ATE143671T1 (de) 1996-10-15
PT98023B (pt) 1998-11-30
AU651347B2 (en) 1994-07-21
AU7843591A (en) 1992-01-16
OA09369A (en) 1992-09-15
DE69122432T2 (de) 1997-03-20
NO912347L (no) 1991-12-19
JP3307410B2 (ja) 2002-07-24
IE990233A1 (en) 2000-11-15
FI912873L (fi) 1991-12-19
IE912046A1 (en) 1991-12-18
CN1059729A (zh) 1992-03-25
IL98506A (en) 1996-09-12
FI912873A0 (fi) 1991-06-14
CN1040541C (zh) 1998-11-04
NO912347D0 (no) 1991-06-17
DK0462531T3 (da) 1996-11-18
EP0462531B1 (en) 1996-10-02
GR3021780T3 (en) 1997-02-28
RU2108342C1 (ru) 1998-04-10

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