ATE144423T1 - Therapeutische benzazepin verbindungen - Google Patents

Therapeutische benzazepin verbindungen

Info

Publication number
ATE144423T1
ATE144423T1 AT92901758T AT92901758T ATE144423T1 AT E144423 T1 ATE144423 T1 AT E144423T1 AT 92901758 T AT92901758 T AT 92901758T AT 92901758 T AT92901758 T AT 92901758T AT E144423 T1 ATE144423 T1 AT E144423T1
Authority
AT
Austria
Prior art keywords
treatment
therapeutic
formula
neurological disorders
benzazepine compounds
Prior art date
Application number
AT92901758T
Other languages
English (en)
Inventor
Marc Jerome Chapdelaine
Charles David Mclaren
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE144423T1 publication Critical patent/ATE144423T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT92901758T 1991-01-02 1991-12-30 Therapeutische benzazepin verbindungen ATE144423T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919100028A GB9100028D0 (en) 1991-01-02 1991-01-02 Compounds

Publications (1)

Publication Number Publication Date
ATE144423T1 true ATE144423T1 (de) 1996-11-15

Family

ID=10687882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92901758T ATE144423T1 (de) 1991-01-02 1991-12-30 Therapeutische benzazepin verbindungen

Country Status (22)

Country Link
US (3) US5254683A (de)
EP (1) EP0517876B1 (de)
JP (1) JP3034604B2 (de)
KR (1) KR100229049B1 (de)
AT (1) ATE144423T1 (de)
AU (1) AU650086B2 (de)
CA (1) CA2058593A1 (de)
CZ (1) CZ299292A3 (de)
DE (1) DE69122858T2 (de)
DK (1) DK0517876T3 (de)
ES (1) ES2093246T3 (de)
FI (1) FI104071B (de)
GB (2) GB9100028D0 (de)
GR (1) GR3021440T3 (de)
HU (2) HU212269B (de)
IE (1) IE920009A1 (de)
IL (1) IL100484A (de)
NO (1) NO300497B1 (de)
NZ (1) NZ241197A (de)
PL (1) PL166481B1 (de)
WO (1) WO1992011854A1 (de)
ZA (1) ZA9223B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof
CA2115792C (en) 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
US5834479A (en) * 1993-03-05 1998-11-10 Mayer; David J. Method and composition for alleviating pain
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
JP4989830B2 (ja) * 1999-07-21 2012-08-01 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク 脳によるグルタミン酸塩の放出に対して抑制効果を示す薬剤を製造するためのベータ−ナフトキノン誘導体の使用
FR2796552A1 (fr) 1999-07-21 2001-01-26 Centre Nat Rech Scient Nouvelle utilisation de derives de la beta-naphtoquinone et de leurs sels pour la fabrication de medicaments exercant un effet inhibiteur sur la liberation de glutamate dans le cerveau
JPWO2016199789A1 (ja) * 2015-06-08 2018-03-29 国立大学法人名古屋大学 トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1340334A (en) * 1970-07-06 1973-12-12 Rees A H Synthesis of benzazetropolones and hence of kynurenic acids
DE3269625D1 (en) * 1981-08-11 1986-04-10 Ciba Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4477446A (en) * 1983-07-01 1984-10-16 Usv Pharmaceutical Corporation 1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
WO1991005549A1 (en) * 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof

Also Published As

Publication number Publication date
GB2251616A (en) 1992-07-15
AU650086B2 (en) 1994-06-09
JPH07502007A (ja) 1995-03-02
FI923759L (fi) 1992-08-20
KR100229049B1 (ko) 1999-11-01
GR3021440T3 (en) 1997-01-31
WO1992011854A1 (en) 1992-07-23
PL295932A1 (en) 1993-10-04
ZA9223B (en) 1992-09-30
FI104071B1 (fi) 1999-11-15
GB2251616B (en) 1995-01-11
DE69122858T2 (de) 1997-02-20
NO300497B1 (no) 1997-06-09
HUT64309A (en) 1993-12-28
CA2058593A1 (en) 1992-07-03
HU211466A9 (en) 1995-11-28
EP0517876A1 (de) 1992-12-16
NZ241197A (en) 1994-10-26
CZ299292A3 (en) 1993-01-13
FI923759A0 (fi) 1992-08-20
IE920009A1 (en) 1992-07-15
DE69122858D1 (de) 1996-11-28
US5254683A (en) 1993-10-19
US5541319A (en) 1996-07-30
GB9127498D0 (en) 1992-02-19
PL166481B1 (en) 1995-05-31
HU212269B (en) 1996-07-29
GB9100028D0 (en) 1991-02-20
DK0517876T3 (da) 1997-04-01
JP3034604B2 (ja) 2000-04-17
NO923413D0 (no) 1992-09-01
NO923413L (no) 1992-09-01
US5446039A (en) 1995-08-29
IL100484A0 (en) 1992-09-06
HU9202618D0 (en) 1992-10-28
EP0517876B1 (de) 1996-10-23
FI104071B (fi) 1999-11-15
ES2093246T3 (es) 1996-12-16
AU9134091A (en) 1992-08-17
IL100484A (en) 1997-02-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee