ATE145397T1 - Verfahren zur herstellung von 3-amino-2-chloro-4- alkylpyridinen - Google Patents

Verfahren zur herstellung von 3-amino-2-chloro-4- alkylpyridinen

Info

Publication number
ATE145397T1
ATE145397T1 AT92912917T AT92912917T ATE145397T1 AT E145397 T1 ATE145397 T1 AT E145397T1 AT 92912917 T AT92912917 T AT 92912917T AT 92912917 T AT92912917 T AT 92912917T AT E145397 T1 ATE145397 T1 AT E145397T1
Authority
AT
Austria
Prior art keywords
chloro
amino
alkylpyridines
producing
preparation
Prior art date
Application number
AT92912917T
Other languages
English (en)
Inventor
Karl G Grozinger
Karl D Hargrave
Julian Adams
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24870473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE145397(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE145397T1 publication Critical patent/ATE145397T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT92912917T 1991-06-11 1992-05-29 Verfahren zur herstellung von 3-amino-2-chloro-4- alkylpyridinen ATE145397T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71454991A 1991-06-11 1991-06-11

Publications (1)

Publication Number Publication Date
ATE145397T1 true ATE145397T1 (de) 1996-12-15

Family

ID=24870473

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912917T ATE145397T1 (de) 1991-06-11 1992-05-29 Verfahren zur herstellung von 3-amino-2-chloro-4- alkylpyridinen

Country Status (14)

Country Link
US (1) US5668287A (de)
EP (1) EP0551459B1 (de)
JP (1) JP3133331B2 (de)
KR (1) KR100201725B1 (de)
AT (1) ATE145397T1 (de)
AU (1) AU652656B2 (de)
CA (1) CA2082801C (de)
DE (1) DE69215346T2 (de)
DK (1) DK0551459T3 (de)
ES (1) ES2094913T3 (de)
GR (1) GR3022398T3 (de)
HU (1) HU213257B (de)
MX (1) MX9202769A (de)
WO (1) WO1992022531A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0598396T3 (da) * 1992-11-18 1998-11-23 Boehringer Ingelheim Pharma Forbedret fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner
CA2155214C (en) * 1993-12-02 2005-03-29 Heinrich Schneider Method for preparing 3-amino-2-chloro-4-alkylpyridine or -4-arylpyridine
WO2000043365A1 (en) * 1999-01-22 2000-07-27 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
JP2002535310A (ja) * 1999-01-22 2002-10-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド アセトン及びエチルシアノアセテートからの３‐アミノ−２−クロロ−４‐メチルピリジンの合成
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
JP2002322152A (ja) * 2001-04-24 2002-11-08 Koei Chem Co Ltd シアノピリジン類の製造方法
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
CA2798716A1 (en) 2011-12-13 2013-06-13 Endochoice Innovation Center Ltd. Removable tip endoscope
CN112479993A (zh) * 2019-09-11 2021-03-12 凯瑞斯德生化(苏州)有限公司 一种应用于kras抑制剂类药物杂环中间体的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372690A (en) * 1940-11-15 1945-04-03 Merck & Co Inc Intermediates for the production of vitamin b6 and processes of preparing the same
US3703582A (en) * 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
DE2310747A1 (de) * 1973-03-03 1974-09-12 Bayer Ag Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel
US4442100A (en) * 1979-12-11 1984-04-10 Bayer Aktiengesellschaft Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines

Also Published As

Publication number Publication date
ES2094913T3 (es) 1997-02-01
DK0551459T3 (da) 1997-04-07
GR3022398T3 (en) 1997-04-30
AU652656B2 (en) 1994-09-01
KR930701405A (ko) 1993-06-11
DE69215346D1 (de) 1997-01-02
CA2082801C (en) 2003-07-08
MX9202769A (es) 1993-01-01
JP3133331B2 (ja) 2001-02-05
DE69215346T2 (de) 1997-04-30
US5668287A (en) 1997-09-16
EP0551459A4 (de) 1994-03-16
WO1992022531A1 (en) 1992-12-23
HUT64027A (en) 1993-11-29
AU2180792A (en) 1993-01-12
KR100201725B1 (ko) 1999-06-15
CA2082801A1 (en) 1992-12-12
HU9300337D0 (en) 1993-05-28
EP0551459A1 (de) 1993-07-21
HU213257B (en) 1997-04-28
EP0551459B1 (de) 1996-11-20
JPH06500800A (ja) 1994-01-27

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee