KR100201725B1 - 3-아미노-2-클로로-4-알킬피리딘의 제조방법 - Google Patents

3-아미노-2-클로로-4-알킬피리딘의 제조방법 Download PDF

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Publication number
KR100201725B1
KR100201725B1 KR1019920703184A KR920703184A KR100201725B1 KR 100201725 B1 KR100201725 B1 KR 100201725B1 KR 1019920703184 A KR1019920703184 A KR 1019920703184A KR 920703184 A KR920703184 A KR 920703184A KR 100201725 B1 KR100201725 B1 KR 100201725B1
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South Korea
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temperature
hours
methylpyridine
compound
produced
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Expired - Fee Related
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KR1019920703184A
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English (en)
Korean (ko)
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KR930701405A (ko
Inventor
쥐 그로징거 칼
칼디.하그레이브
아담스 줄리안
Original Assignee
데이비드 이. 프랭크하우저
베링거 인겔하임 파마슈티칼즈 인코포레이티드
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Application filed by 데이비드 이. 프랭크하우저, 베링거 인겔하임 파마슈티칼즈 인코포레이티드 filed Critical 데이비드 이. 프랭크하우저
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019920703184A 1991-06-11 1992-10-26 3-아미노-2-클로로-4-알킬피리딘의 제조방법 Expired - Fee Related KR100201725B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71454991A 1991-06-11 1991-06-11
US714,549 1991-06-11
PCT/US1992/004761 WO1992022531A1 (en) 1991-06-11 1992-05-29 Method for the preparation of 3-amino-2-chloro-4-alkylpyridines

Publications (2)

Publication Number Publication Date
KR930701405A KR930701405A (ko) 1993-06-11
KR100201725B1 true KR100201725B1 (ko) 1999-06-15

Family

ID=24870473

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703184A Expired - Fee Related KR100201725B1 (ko) 1991-06-11 1992-10-26 3-아미노-2-클로로-4-알킬피리딘의 제조방법

Country Status (14)

Country Link
US (1) US5668287A (de)
EP (1) EP0551459B1 (de)
JP (1) JP3133331B2 (de)
KR (1) KR100201725B1 (de)
AT (1) ATE145397T1 (de)
AU (1) AU652656B2 (de)
CA (1) CA2082801C (de)
DE (1) DE69215346T2 (de)
DK (1) DK0551459T3 (de)
ES (1) ES2094913T3 (de)
GR (1) GR3022398T3 (de)
HU (1) HU213257B (de)
MX (1) MX9202769A (de)
WO (1) WO1992022531A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2121916T3 (es) * 1992-11-18 1998-12-16 Boehringer Ingelheim Pharma Metodo mejorado para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.
US5686618A (en) * 1993-12-02 1997-11-11 Boehringer Ingelheim Kg Method for preparing 3-amino-2-chloro-4-alkylpyridine or-4-arylpyridine
US6111112A (en) * 1999-01-22 2000-08-29 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
JP2002535310A (ja) * 1999-01-22 2002-10-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド アセトン及びエチルシアノアセテートからの３‐アミノ−２−クロロ−４‐メチルピリジンの合成
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
JP2002322152A (ja) * 2001-04-24 2002-11-08 Koei Chem Co Ltd シアノピリジン類の製造方法
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
CA2798716A1 (en) 2011-12-13 2013-06-13 Endochoice Innovation Center Ltd. Removable tip endoscope
US20220259150A1 (en) * 2019-09-11 2022-08-18 Chiral Quest (Suzhou) Co., Ltd. Synthesis method applied to kras inhibitor drug heterocyclic intermediate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372690A (en) * 1940-11-15 1945-04-03 Merck & Co Inc Intermediates for the production of vitamin b6 and processes of preparing the same
US3703582A (en) 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
DE2310747A1 (de) 1973-03-03 1974-09-12 Bayer Ag Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel
US4442100A (en) 1979-12-11 1984-04-10 Bayer Aktiengesellschaft Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines

Also Published As

Publication number Publication date
MX9202769A (es) 1993-01-01
DE69215346T2 (de) 1997-04-30
JP3133331B2 (ja) 2001-02-05
CA2082801C (en) 2003-07-08
ES2094913T3 (es) 1997-02-01
AU652656B2 (en) 1994-09-01
ATE145397T1 (de) 1996-12-15
WO1992022531A1 (en) 1992-12-23
US5668287A (en) 1997-09-16
DE69215346D1 (de) 1997-01-02
EP0551459B1 (de) 1996-11-20
JPH06500800A (ja) 1994-01-27
DK0551459T3 (da) 1997-04-07
GR3022398T3 (en) 1997-04-30
EP0551459A4 (de) 1994-03-16
EP0551459A1 (de) 1993-07-21
KR930701405A (ko) 1993-06-11
HUT64027A (en) 1993-11-29
HU213257B (en) 1997-04-28
AU2180792A (en) 1993-01-12
HU9300337D0 (en) 1993-05-28
CA2082801A1 (en) 1992-12-12

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