ATE145912T1 - Bisplatinum-komplexe als chemotherapeutisches mittel - Google Patents

Bisplatinum-komplexe als chemotherapeutisches mittel

Info

Publication number: ATE145912T1
Authority: AT; Austria
Prior art keywords: chemotherapeutic agent; complexes; same; carboxylate; bisplatinum
Prior art date: 1986-07-25

Application number

AT87905092T

Other languages

English (en)

Inventor

Nicholas Farrell

Miles Paul Hacker

John J Mccormack

Sergio Gama Dealmeida

Original Assignee

Univ Vermont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-25

Filing date

1987-07-24

Publication date

1996-12-15

1987-07-24 Application filed by Univ Vermont filed Critical Univ Vermont

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145912T1 publication Critical patent/ATE145912T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 title 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 4
229910052697 platinum Inorganic materials 0.000 abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
150000007942 carboxylates Chemical class 0.000 abstract 2
229910002651 NO3 Inorganic materials 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
150000004985 diamines Chemical class 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
229920000768 polyamine Polymers 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003335 secondary amines Chemical class 0.000 abstract 1
229910021653 sulphate ion Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT87905092T 1986-07-25 1987-07-24 Bisplatinum-komplexe als chemotherapeutisches mittel ATE145912T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/889,397 US4797393A (en)	1986-07-25	1986-07-25	Bis-platinum complexes as chemotherapeutic agents

Publications (1)

Publication Number	Publication Date
ATE145912T1 true ATE145912T1 (de)	1996-12-15

Family

ID=25395019

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87905092T ATE145912T1 (de)	1986-07-25	1987-07-24	Bisplatinum-komplexe als chemotherapeutisches mittel

Country Status (8)

Country	Link
US (1)	US4797393A (de)
EP (1)	EP0275297B1 (de)
JP (1)	JP2537531B2 (de)
AT (1)	ATE145912T1 (de)
AU (1)	AU609049B2 (de)
CA (1)	CA1340892C (de)
DE (1)	DE3751967T2 (de)
WO (1)	WO1988000947A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5107007A (en) *	1989-09-01	1992-04-21	The University Of Vermont And State Agricultural College	Bis-platinum complexes as chemotherapeutic agents
US5770591A (en) *	1986-07-25	1998-06-23	The University Of Vermont And State Agricultural College	Bis-platinum complexes as chemotherapeutic agents
FR2635317B1 (fr) *	1988-08-11	1990-10-19	Norsolor Sa	Hydrures de platine de structure bimetallique pontee, leur procede de preparation et leur application a la catalyse de reactions chimiques
JPH02275891A (ja) *	1988-12-29	1990-11-09	Tsumura & Co	新規な複核白金錯体および該錯体を有効成分とする抗腫瘍剤
KR940010295B1 (ko) *	1991-07-05	1994-10-22	한국과학기술연구원	신규 항암성 백금 착화합물 유도체 및 그 제조방법
US5380897A (en) *	1993-05-25	1995-01-10	Hoeschele; James D.	Tri(platinum) complexes
US5409915A (en) *	1993-09-14	1995-04-25	The University Of Vermont And State Agricultural College	Bis-platinum (IV) complexes as chemotherapeutic agents
ZA976422B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ZA976421B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polyamine ligands as antitumor agents.
WO2000006136A2 (en) *	1998-07-31	2000-02-10	The Health Research, Inc.	Therapeutic combination of polyamine with an anticancer agent
US6130245A (en) *	1998-10-26	2000-10-10	Unitech Pharmaceuticals, Inc.	Dinuclear platinum complexes as cisplatin analogs for cancer treatment
US7579373B2 (en)	2001-08-22	2009-08-25	Virginia Commonwealth University	Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
US7160908B2 (en) *	2003-03-04	2007-01-09	Unitech Pharmaceuticals, Inc.	Dynamic anticancer platinum compounds
CN1922187A (zh) *	2004-01-15	2007-02-28	新南创新有限公司	由葫芦形联脲[7－12]部分包封的多核金属配合物
US20050256239A1 (en) *	2004-05-11	2005-11-17	Lee Chun D	White polyolefin compositions having reduced die drool
WO2006095477A1 (ja) *	2005-03-09	2006-09-14	Inter-University Research Institute Corporation National Institutes Of Natural Sciences	レジン白金複合体及びレジン担持白金クラスター触媒
ITMI20052449A1 (it) *	2005-12-22	2007-06-23	Cell Therapeutics Europe Srl	Nuovi bis-platino complessi ad attivita' antitumorale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4225529A (en) *	1977-10-19	1980-09-30	Johnson, Matthey & Co., Limited	Compositions containing platinum
SE7903361L (sv) *	1978-04-20	1979-10-21	Johnson Matthey Co Ltd	Kompositioner innehallande platina
US4533502A (en) *	1983-02-22	1985-08-06	Rochon Fernande D	Platinum (II) compounds and their preparation
US4565884A (en) *	1983-05-10	1986-01-21	Andrulis Research Corporation	Bis-platinum complexes as antitumor agents
US4571335A (en) *	1983-06-17	1986-02-18	Taylor Robert C	Method of inhibiting herpetic lesions by the use of platinum coordination compounds
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel

1986
- 1986-07-25 US US06/889,397 patent/US4797393A/en not_active Expired - Lifetime
1987
- 1987-07-23 CA CA000542812A patent/CA1340892C/en not_active Expired - Lifetime
- 1987-07-24 AU AU76994/87A patent/AU609049B2/en not_active Expired
- 1987-07-24 EP EP87905092A patent/EP0275297B1/de not_active Expired - Lifetime
- 1987-07-24 JP JP62504563A patent/JP2537531B2/ja not_active Expired - Lifetime
- 1987-07-24 DE DE3751967T patent/DE3751967T2/de not_active Expired - Lifetime
- 1987-07-24 WO PCT/US1987/001738 patent/WO1988000947A1/en not_active Ceased
- 1987-07-24 AT AT87905092T patent/ATE145912T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4797393A (en)	1989-01-10
JP2537531B2 (ja)	1996-09-25
DE3751967T2 (de)	1997-05-15
AU609049B2 (en)	1991-04-26
WO1988000947A1 (en)	1988-02-11
CA1340892C (en)	2000-02-08
EP0275297A1 (de)	1988-07-27
JPH01501309A (ja)	1989-05-11
EP0275297B1 (de)	1996-12-04
DE3751967D1 (de)	1997-01-16
EP0275297A4 (en)	1990-09-12
AU7699487A (en)	1988-02-24

Legal Events

Date	Code	Title	Description
1997-08-15	UEP	Publication of translation of european patent specification
2007-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE145912T1 (de)	1996-12-15	Bisplatinum-komplexe als chemotherapeutisches mittel
ATE145210T1 (de)	1996-11-15	Neue bis-platinkomplexe als chemotherapeutisches mittel
GB1380228A (en)	1975-01-08	Malonato-platinum anti-tumour compounds
ATE19520T1 (de)	1986-05-15	Loesliche platin(ii)-komplexe.
ES2001586A6 (es)	1988-06-01	Un procedimiento para producir un complejo de diamina platino (ii)
ATE56949T1 (de)	1990-10-15	Carboxy, carbalkoxy und carbamyl substituierte isonitril-radionukleid-komplexe.
GB1242019A (en)	1971-08-11	Improvements in pyrazoline-derived optical brighteners
DK0753000T3 (da)	1999-09-20	Trinukleare kationiske platinkomplekser med antitumoraktivitet og farmaceutiske præparater indeholdende dem
GB1460235A (en)	1976-12-31	Vincaminic acid amides
Nagao et al.	1994	Nuclear Magnetic Resonance Studies on the Structure of Ruthenium (II) Complexes of Di-2-pyridylamine in DMSO Solution.
GB1378127A (en)	1974-12-18	Scopolamine derivatives
DE3671452D1 (de)	1990-06-28	Technetium-aren-komplexe und verfahren.
DE69028844D1 (de)	1996-11-14	Neuer platin(ii)komplex und mittel für die behandlung von bösartigen tumoren
GB1383386A (en)	1974-02-12	Azodicarbonamidine salts and their use as silver halide fog inhibitors
GB1319506A (en)	1973-06-06	Compsitions containing iron chelates
GB1498753A (en)	1978-01-25	Dicarboxylic acid derivatives containing heterocyclic radicals
GB1411373A (en)	1975-10-22	Azomonocarbonamides and their use in photographic silver halide emulsions
PH25038A (en)	1991-01-28	Anti-tumor platinum complexes
JPS52108963A (en)	1977-09-12	Prodution of estoramstine phosphatealcohol complex and utilizing method of same as intermediate duaring purifying said compound and salt thereof
GB1499123A (en)	1978-01-25	Hardening of photographic layers
GB2006776A (en)	1979-05-10	Platinum (II) Complexes with Amines
ATE236179T1 (de)	2003-04-15	Nitrate von bis-platinum komplexen mit polyamin
KR860001823A (ko)	1986-03-22	아스코르브산의 백금 착화합물 및 아스코르브산 유사체의 제조방법
Pellacani et al.	1975	Tetramethyl-and tetraethyl-dithiooxamide complexes of tin (II) and tin (IV) halides; preparation, conductivities and ir spectra
GB2006777A (en)	1979-05-10	Platinum-Amine Complexes