ATE145915T1 - O-heteroaryl, o-alkylheteroaryl, o- alkenylheteroaryl und o-alkynylheteroaryl- makrolide - Google Patents

O-heteroaryl, o-alkylheteroaryl, o- alkenylheteroaryl und o-alkynylheteroaryl- makrolide

Info

Publication number
ATE145915T1
ATE145915T1 AT92202658T AT92202658T ATE145915T1 AT E145915 T1 ATE145915 T1 AT E145915T1 AT 92202658 T AT92202658 T AT 92202658T AT 92202658 T AT92202658 T AT 92202658T AT E145915 T1 ATE145915 T1 AT E145915T1
Authority
AT
Austria
Prior art keywords
alkenylheteroaryl
alkylheteroaryl
heteroaryl
diseases
alkynylheteroaryl macrolides
Prior art date
Application number
AT92202658T
Other languages
English (en)
Inventor
Peter J Sinclair
Mark Goulet
Frederick Wong
William H Parsons
Joung Goulet
Matthew J Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE145915T1 publication Critical patent/ATE145915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement Of Force In General (AREA)
  • Steroid Compounds (AREA)
AT92202658T 1991-09-09 1992-09-02 O-heteroaryl, o-alkylheteroaryl, o- alkenylheteroaryl und o-alkynylheteroaryl- makrolide ATE145915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75694691A 1991-09-09 1991-09-09
US07/921,851 US5252732A (en) 1991-09-09 1992-08-05 D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Publications (1)

Publication Number Publication Date
ATE145915T1 true ATE145915T1 (de) 1996-12-15

Family

ID=27116312

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92202658T ATE145915T1 (de) 1991-09-09 1992-09-02 O-heteroaryl, o-alkylheteroaryl, o- alkenylheteroaryl und o-alkynylheteroaryl- makrolide

Country Status (21)

Country Link
US (2) US5252732A (de)
EP (1) EP0532088B1 (de)
JP (1) JPH0813819B2 (de)
KR (1) KR930006030A (de)
CN (1) CN1073443A (de)
AT (1) ATE145915T1 (de)
AU (1) AU647665B2 (de)
BG (1) BG98639A (de)
CA (1) CA2077331A1 (de)
CZ (1) CZ53194A3 (de)
DE (1) DE69215615T2 (de)
FI (1) FI941085L (de)
HU (1) HUT66855A (de)
IL (1) IL103009A0 (de)
MX (1) MX9205137A (de)
NO (1) NO940805L (de)
NZ (1) NZ244153A (de)
RO (1) RO114331B1 (de)
SK (1) SK26094A3 (de)
WO (1) WO1993005058A1 (de)
YU (1) YU89792A (de)

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US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
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US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
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US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
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US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
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PT2198858E (pt) 1998-03-26 2011-09-01 Astellas Pharma Inc Composição farmacêutica de libertação constante que contém um macrólido como o tacrolimus
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AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
BR0307544A (pt) * 2002-02-01 2004-12-07 Ariad Gene Therapeutics Inc Compostos contendo fósforos, componentes e composição bem como, sua utilização através de métodos de tratamentos
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
JP2007516951A (ja) * 2003-12-30 2007-06-28 アステラス製薬株式会社 気道閉塞症の治療または予防のためのマクロライドの使用
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
JP2008513388A (ja) * 2004-09-16 2008-05-01 バイエル・ヘルスケア・アクチェンゲゼルシャフト 動物の皮膚病を処置するための皮膚投与可能な製剤
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
TW200637552A (en) * 2005-01-20 2006-11-01 Array Biopharma Inc Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
US20090054667A1 (en) * 2005-08-10 2009-02-26 Replidyne, Inc. Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
CA2669415A1 (en) * 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Solid dosage form comprising ap23573
EP2245165A4 (de) * 2008-01-11 2011-06-01 Massachusetts Eye & Ear Infirm Transgene konditionalstopp-dimerisierbare-caspase-tiere
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
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CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
US20210228551A1 (en) 2018-08-10 2021-07-29 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
CN109467579B (zh) * 2018-11-01 2021-10-15 海南大学 一种具有免疫抑制活性的pks i型聚酮类化合物及其制备方法和应用
CA3123535A1 (en) 2018-12-18 2020-06-25 Koushi Yamaguchi Agent for improving infertility, recurrent miscarriage, and state of pregnancy

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Also Published As

Publication number Publication date
FI941085A7 (fi) 1994-05-03
NO940805L (no) 1994-05-06
CA2077331A1 (en) 1993-03-10
YU89792A (sh) 1996-01-08
US5349061A (en) 1994-09-20
FI941085L (fi) 1994-05-03
NO940805D0 (no) 1994-03-08
US5252732A (en) 1993-10-12
IL103009A0 (en) 1993-02-21
HU9400686D0 (en) 1994-06-28
EP0532088A1 (de) 1993-03-17
CZ53194A3 (en) 1994-08-17
SK26094A3 (en) 1994-08-10
JPH06116274A (ja) 1994-04-26
KR930006030A (ko) 1993-04-20
CN1073443A (zh) 1993-06-23
WO1993005058A1 (en) 1993-03-18
BG98639A (bg) 1995-03-31
JPH0813819B2 (ja) 1996-02-14
MX9205137A (es) 1993-04-01
EP0532088B1 (de) 1996-12-04
AU2282992A (en) 1993-03-11
FI941085A0 (fi) 1994-03-08
AU647665B2 (en) 1994-03-24
NZ244153A (en) 1995-04-27
HUT66855A (en) 1995-01-30
DE69215615D1 (de) 1997-01-16
RO114331B1 (ro) 1999-03-30
DE69215615T2 (de) 1997-06-26

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