ATE409048T1 - Pharmazeutisch aktive oligosaccharid-conjugate - Google Patents
Pharmazeutisch aktive oligosaccharid-conjugateInfo
- Publication number
- ATE409048T1 ATE409048T1 AT03755568T AT03755568T ATE409048T1 AT E409048 T1 ATE409048 T1 AT E409048T1 AT 03755568 T AT03755568 T AT 03755568T AT 03755568 T AT03755568 T AT 03755568T AT E409048 T1 ATE409048 T1 AT E409048T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutically active
- present
- oligosaccharide conjugates
- oligosaccharide
- conjugates
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title abstract 6
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 6
- 230000001588 bifunctional effect Effects 0.000 abstract 2
- 150000001720 carbohydrates Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20215415U DE20215415U1 (de) | 2002-10-08 | 2002-10-08 | Wasserlösliche Medikamentenvorstufen von Propofol |
| EP03008177 | 2003-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409048T1 true ATE409048T1 (de) | 2008-10-15 |
Family
ID=32094883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03755568T ATE409048T1 (de) | 2002-10-08 | 2003-10-08 | Pharmazeutisch aktive oligosaccharid-conjugate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7538092B2 (de) |
| EP (1) | EP1549350B1 (de) |
| AT (1) | ATE409048T1 (de) |
| AU (1) | AU2003273413A1 (de) |
| DE (1) | DE60323756D1 (de) |
| ES (1) | ES2314238T3 (de) |
| WO (1) | WO2004032971A1 (de) |
Families Citing this family (49)
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| DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| DE10209822A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
| RU2329274C2 (ru) * | 2002-09-11 | 2008-07-20 | Фрезениус Каби Дойчланд Гмбх | Способ получения производных гидроксиалкилкрахмала |
| BRPI0413450A (pt) * | 2003-08-08 | 2006-10-17 | Fresenius Kabi De Gmbh | conjugados de hidroxialquil amido e g-csf |
| WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| CN102302787A (zh) * | 2004-03-11 | 2012-01-04 | 费森尤斯卡比德国有限公司 | 羟烷基淀粉和蛋白质的接合物 |
| CA2558738C (en) * | 2004-03-11 | 2013-02-05 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| AU2006222187A1 (en) * | 2005-03-11 | 2006-09-14 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch |
| AU2006283726C1 (en) | 2005-08-24 | 2015-05-07 | Immunogen, Inc. | Process for preparing maytansinoid antibody conjugates |
| EP1762250A1 (de) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen |
| WO2007052641A1 (ja) * | 2005-11-01 | 2007-05-10 | Kumamoto University | 腸管免疫賦活剤 |
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| US9023813B2 (en) * | 2011-04-13 | 2015-05-05 | NuTek Pharma Ltd. | Synthesis and use of glycoside derivatives of propofol |
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| WO2012145392A2 (en) * | 2011-04-18 | 2012-10-26 | Curators Of The University Of Missouri | Saccharide conjugates |
| JP6240599B2 (ja) * | 2011-07-19 | 2017-11-29 | セルモザイク， インコーポレイテッド | 新規の架橋試薬、高分子、治療用コンジュゲートおよびその合成法 |
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| US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744239B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
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| CN105031666B (zh) * | 2015-08-27 | 2018-11-16 | 上海交通大学 | 用于治疗肿瘤的两亲性缀合物纳米颗粒及制备方法、应用 |
| JP2020532565A (ja) | 2017-09-05 | 2020-11-12 | トルク セラピューティクス， インコーポレイテッド | 可逆性リンカーおよびその使用 |
| EP3678701A4 (de) | 2017-09-05 | 2021-12-01 | Torque Therapeutics, Inc. | Therapeutische proteinzusammensetzungen und verfahren zur herstellung und verwendung davon |
| US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11439653B1 (en) | 2021-03-30 | 2022-09-13 | Epalex Corporation | Fospropofol formulations |
| US11547714B2 (en) | 2020-02-05 | 2023-01-10 | Epalex Corporation | Fospropofol salts, methods and compositions |
| US11628178B2 (en) | 2019-03-26 | 2023-04-18 | Epalex Corporation | Fospropofol methods and compositions |
| US11478490B1 (en) | 2021-03-30 | 2022-10-25 | Epalex Corporation | Fospropofol formulations |
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-
2003
- 2003-10-08 ES ES03755568T patent/ES2314238T3/es not_active Expired - Lifetime
- 2003-10-08 AU AU2003273413A patent/AU2003273413A1/en not_active Abandoned
- 2003-10-08 US US10/530,849 patent/US7538092B2/en not_active Expired - Fee Related
- 2003-10-08 EP EP03755568A patent/EP1549350B1/de not_active Expired - Lifetime
- 2003-10-08 WO PCT/EP2003/011129 patent/WO2004032971A1/en not_active Ceased
- 2003-10-08 DE DE60323756T patent/DE60323756D1/de not_active Expired - Lifetime
- 2003-10-08 AT AT03755568T patent/ATE409048T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004032971A1 (en) | 2004-04-22 |
| US20060100163A1 (en) | 2006-05-11 |
| EP1549350A1 (de) | 2005-07-06 |
| AU2003273413A1 (en) | 2004-05-04 |
| ES2314238T3 (es) | 2009-03-16 |
| DE60323756D1 (de) | 2008-11-06 |
| EP1549350B1 (de) | 2008-09-24 |
| US7538092B2 (en) | 2009-05-26 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |