ATE147794T1 - Chemisches verfahren zur analyse von dns- sequenzen - Google Patents
Chemisches verfahren zur analyse von dns- sequenzenInfo
- Publication number
- ATE147794T1 ATE147794T1 AT93909986T AT93909986T ATE147794T1 AT E147794 T1 ATE147794 T1 AT E147794T1 AT 93909986 T AT93909986 T AT 93909986T AT 93909986 T AT93909986 T AT 93909986T AT E147794 T1 ATE147794 T1 AT E147794T1
- Authority
- AT
- Austria
- Prior art keywords
- dna
- dideoxynucleotide
- subjected
- pct
- immobilised
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 abstract 9
- 239000005546 dideoxynucleotide Substances 0.000 abstract 6
- 102000053602 DNA Human genes 0.000 abstract 2
- 108020004682 Single-Stranded DNA Proteins 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929210176A GB9210176D0 (en) | 1992-05-12 | 1992-05-12 | Chemical method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE147794T1 true ATE147794T1 (de) | 1997-02-15 |
Family
ID=10715369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93909986T ATE147794T1 (de) | 1992-05-12 | 1993-05-12 | Chemisches verfahren zur analyse von dns- sequenzen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5534424A (de) |
| EP (1) | EP0641390B2 (de) |
| JP (1) | JP3421036B2 (de) |
| AT (1) | ATE147794T1 (de) |
| AU (1) | AU669365B2 (de) |
| CA (1) | CA2135607C (de) |
| DE (1) | DE69307503T3 (de) |
| GB (1) | GB9210176D0 (de) |
| WO (1) | WO1993023562A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712125A (en) * | 1990-07-24 | 1998-01-27 | Cemv Bioteknik Ab | Competitive PCR for quantitation of DNA |
| US5480783A (en) * | 1994-03-31 | 1996-01-02 | The Perkin-Elmer Corporation | Method for reducing background signals in DNA replication/detection assays |
| GB9517914D0 (en) * | 1995-09-02 | 1995-11-01 | Tepnel Medical Ltd | Identification of bases in nucleic acid sequences |
| US5783398A (en) * | 1995-09-15 | 1998-07-21 | Merck & Co., Inc. | High throughput assay using fusion proteins |
| WO1997010253A1 (en) * | 1995-09-15 | 1997-03-20 | Merck & Co., Inc. | A high throughput assay using fusion proteins |
| AU719691B2 (en) * | 1996-01-26 | 2000-05-18 | Innogenetics N.V. | Method for detection of drug-induced mutations in the reverse transcriptase gene |
| GB9620209D0 (en) * | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6096273A (en) * | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7381525B1 (en) * | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
| US7622294B2 (en) * | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US5849497A (en) * | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| AU746892B2 (en) * | 1997-04-04 | 2002-05-02 | Caliper Life Sciences, Inc. | Closed-loop biochemical analyzers |
| US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| GB2324865B (en) * | 1997-05-02 | 2001-05-02 | William Joseph Harris | Materials and methods for detecting amplified nucleic acids |
| WO1998055653A1 (en) * | 1997-06-06 | 1998-12-10 | Nexstar Pharmaceuticals, Inc. | Nucleic acid detection |
| GB9714716D0 (en) * | 1997-07-11 | 1997-09-17 | Brax Genomics Ltd | Characterising nucleic acids |
| US5916776A (en) * | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide |
| US20030203394A1 (en) * | 1998-05-04 | 2003-10-30 | Yoav Eichen | Detection of a target in a sample |
| US20050244954A1 (en) * | 1998-06-23 | 2005-11-03 | Blackburn Gary F | Binding acceleration techniques for the detection of analytes |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| WO2000036151A1 (en) | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A heterogeneous assay for pyrophosphate detection |
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US20050191698A1 (en) * | 1999-04-20 | 2005-09-01 | Illumina, Inc. | Nucleic acid sequencing using microsphere arrays |
| US20030108867A1 (en) * | 1999-04-20 | 2003-06-12 | Chee Mark S | Nucleic acid sequencing using microsphere arrays |
| KR100341626B1 (ko) * | 1999-05-06 | 2002-06-22 | 이진성 | 근경련선-간질 락트산성증 및 뇌졸증 진단용 키트 |
| EP1072679A3 (de) * | 1999-07-20 | 2002-07-31 | Agilent Technologies, Inc. (a Delaware corporation) | Methode zur Herstelung von Nucleinsäuremolekülen mit einer reduzierten Sekundärstruktur |
| JP3926625B2 (ja) | 1999-07-26 | 2007-06-06 | クリニカル・マイクロ・センサーズ・インコーポレイテッド | 電子検出を用いる核酸の配列決定 |
| US7244559B2 (en) * | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) * | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US6348317B1 (en) * | 1999-11-18 | 2002-02-19 | The Arizona Board Of Regents | Fluorescent and DNA cleavage properties of peptide/dye conjugates |
| US6518024B2 (en) | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
| US6770441B2 (en) * | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
| US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
| JP3442338B2 (ja) | 2000-03-17 | 2003-09-02 | 株式会社日立製作所 | Dna分析装置、dna塩基配列決定装置、dna塩基配列決定方法、および反応モジュール |
| JP3638516B2 (ja) * | 2000-09-28 | 2005-04-13 | 株式会社日立製作所 | 核酸検出方法および核酸検出キット |
| US9708358B2 (en) | 2000-10-06 | 2017-07-18 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| US6664079B2 (en) | 2000-10-06 | 2003-12-16 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| US20030143556A1 (en) * | 2001-04-03 | 2003-07-31 | Gary Blackburn | Nucleic acid reactions using labels with different redox potentials |
| WO2003087388A2 (en) * | 2001-07-03 | 2003-10-23 | The Board Of Trustees Of The Leland Stanford University | Bioluminescence regenerative cycle (brc) for nucleic acid quantification |
| US20050009022A1 (en) * | 2001-07-06 | 2005-01-13 | Weiner Michael P. | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
| US20030022150A1 (en) * | 2001-07-24 | 2003-01-30 | Sampson Jeffrey R. | Methods for detecting a target molecule |
| US20030054396A1 (en) * | 2001-09-07 | 2003-03-20 | Weiner Michael P. | Enzymatic light amplification |
| US20050124022A1 (en) * | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6956114B2 (en) | 2001-10-30 | 2005-10-18 | '454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
| US7057026B2 (en) * | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| AU2003259350A1 (en) * | 2002-08-23 | 2004-03-11 | Solexa Limited | Modified nucleotides for polynucleotide sequencing |
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| US20040197793A1 (en) * | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for biomolecule detection, identification, quantification and/or sequencing |
| US20040197845A1 (en) * | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for pathogen detection, identification and/or quantification |
| AU2004209001B2 (en) * | 2003-01-29 | 2007-10-11 | 454 Life Sciences Corporation | Bead emulsion nucleic acid amplification |
| US7575865B2 (en) * | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| US20040219532A1 (en) * | 2003-04-30 | 2004-11-04 | Sampson Jeffrey R. | Internal references measurements |
| GB0406864D0 (en) | 2004-03-26 | 2004-04-28 | Qiagen As | Nucleic acid sequencing |
| GB0416944D0 (en) | 2004-07-29 | 2004-09-01 | Lumora Ltd | Method for determining the amount of template nucleic acid present in a sample |
| GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
| US8399188B2 (en) | 2006-09-28 | 2013-03-19 | Illumina, Inc. | Compositions and methods for nucleotide sequencing |
| US7883869B2 (en) | 2006-12-01 | 2011-02-08 | The Trustees Of Columbia University In The City Of New York | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators |
| EP3431615A3 (de) | 2007-10-19 | 2019-02-20 | The Trustees of Columbia University in the City of New York | Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren |
| WO2009051807A1 (en) | 2007-10-19 | 2009-04-23 | The Trustees Of Columbia University In The City Of New York | Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis |
| JP5188789B2 (ja) * | 2007-11-29 | 2013-04-24 | 株式会社日立製作所 | 核酸の定量方法 |
| CN105377869B (zh) | 2013-03-15 | 2018-07-10 | 伊鲁米纳剑桥有限公司 | 修饰的核苷或核苷酸 |
| US10648026B2 (en) | 2013-03-15 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| GB201315785D0 (en) * | 2013-09-05 | 2013-10-23 | Univ York | Anti-viral agents |
| CN116908265B (zh) * | 2023-09-11 | 2023-12-12 | 常州先趋医疗科技有限公司 | 检测核酸lamp扩增产物电化学生物传感器的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US5135717A (en) * | 1986-12-24 | 1992-08-04 | British Technology Group Usa Inc. | Tetrabenztriazaporphyrin reagents and kits containing the same |
| SE8801070D0 (sv) * | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
| US4971903A (en) * | 1988-03-25 | 1990-11-20 | Edward Hyman | Pyrophosphate-based method and apparatus for sequencing nucleic acids |
| US5817797A (en) * | 1988-06-01 | 1998-10-06 | The United States Of America As Represented By The Department Of Health And Human Services | Sequencing DNA; a modification of the polymerase chain reaction |
| US4962020A (en) † | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
| DK175170B1 (da) † | 1988-11-29 | 2004-06-21 | Sangtec Molecular Diagnostics | Fremgangsmåde og reagenskombination til bestemmmelse af nukleotidsekvenser |
| KR920700360A (ko) * | 1989-03-22 | 1992-02-19 | 하리크 프리드리히 | 미끄럼 베어링 |
| FR2650840B1 (fr) * | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| IL97222A (en) * | 1990-02-16 | 1995-08-31 | Orion Yhtymae Oy | Method and reagent for determining specific nucleotide variations |
| US5595891A (en) † | 1990-07-19 | 1997-01-21 | Behringwerke Ag | Method for producing a polynucleotide for use in single primer amplification |
| US6004744A (en) * | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| CA2073630C (en) * | 1991-08-30 | 2007-12-11 | Atsushi Ohshima | Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor |
| GB9122060D0 (en) * | 1991-10-17 | 1991-11-27 | Dynal As | Method of sequencing double stranded dna |
| GB9210177D0 (en) * | 1992-05-12 | 1992-06-24 | Cemu Bioteknik Ab | Loop structures |
| GB9210168D0 (en) * | 1992-05-12 | 1992-06-24 | Cemu Bioteknik Ab | Method of sequencing dna |
-
1992
- 1992-05-12 GB GB929210176A patent/GB9210176D0/en active Pending
-
1993
- 1993-05-12 EP EP93909986A patent/EP0641390B2/de not_active Expired - Lifetime
- 1993-05-12 WO PCT/EP1993/001203 patent/WO1993023562A1/en not_active Ceased
- 1993-05-12 US US08/331,552 patent/US5534424A/en not_active Expired - Lifetime
- 1993-05-12 AT AT93909986T patent/ATE147794T1/de not_active IP Right Cessation
- 1993-05-12 AU AU40681/93A patent/AU669365B2/en not_active Expired
- 1993-05-12 CA CA002135607A patent/CA2135607C/en not_active Expired - Lifetime
- 1993-05-12 DE DE69307503T patent/DE69307503T3/de not_active Expired - Lifetime
- 1993-05-12 JP JP51989293A patent/JP3421036B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993023562A1 (en) | 1993-11-25 |
| GB9210176D0 (en) | 1992-06-24 |
| DE69307503T2 (de) | 1997-07-10 |
| CA2135607A1 (en) | 1993-11-25 |
| AU669365B2 (en) | 1996-06-06 |
| CA2135607C (en) | 2005-08-02 |
| DE69307503D1 (de) | 1997-02-27 |
| JPH08500724A (ja) | 1996-01-30 |
| EP0641390B1 (de) | 1997-01-15 |
| JP3421036B2 (ja) | 2003-06-30 |
| AU4068193A (en) | 1993-12-13 |
| US5534424A (en) | 1996-07-09 |
| EP0641390B2 (de) | 2003-04-09 |
| DE69307503T3 (de) | 2003-12-11 |
| EP0641390A1 (de) | 1995-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |