ATE236269T1 - Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation - Google Patents
Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikationInfo
- Publication number
- ATE236269T1 ATE236269T1 AT94929300T AT94929300T ATE236269T1 AT E236269 T1 ATE236269 T1 AT E236269T1 AT 94929300 T AT94929300 T AT 94929300T AT 94929300 T AT94929300 T AT 94929300T AT E236269 T1 ATE236269 T1 AT E236269T1
- Authority
- AT
- Austria
- Prior art keywords
- detection
- electrochemiluminescenter
- self
- nucleic acids
- sequence replication
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108020004682 Single-Stranded DNA Proteins 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12468693A | 1993-09-22 | 1993-09-22 | |
| PCT/US1994/010732 WO1995008644A1 (en) | 1993-09-22 | 1994-09-21 | Self-sustained sequence replication electrochemiluminescent nucleic acid assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236269T1 true ATE236269T1 (de) | 2003-04-15 |
Family
ID=22416276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94929300T ATE236269T1 (de) | 1993-09-22 | 1994-09-21 | Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6048687A (de) |
| EP (1) | EP0722508B1 (de) |
| JP (2) | JPH09505464A (de) |
| AT (1) | ATE236269T1 (de) |
| AU (1) | AU700055B2 (de) |
| CA (1) | CA2172248C (de) |
| DE (1) | DE69432419T2 (de) |
| WO (1) | WO1995008644A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890712B1 (en) * | 1993-09-22 | 2005-05-10 | Bioveris Corporation | Cycling DNA/RNA amplification electrochemiluminescent probe assay |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| DE19644248A1 (de) * | 1996-10-24 | 1998-04-30 | Boehringer Mannheim Gmbh | Primer und Probes zum Nachweis von HIV |
| US6365346B1 (en) | 1998-02-18 | 2002-04-02 | Dade Behring Inc. | Quantitative determination of nucleic acid amplification products |
| US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
| US6448004B1 (en) | 1999-10-05 | 2002-09-10 | Aventis Pharmaceuticals Inc. | Electrochemiluminescence helicase assay |
| US7029919B2 (en) | 2001-05-04 | 2006-04-18 | Agilent Technologies, Inc. | Electro-optical device and methods for hybridization and detection |
| US20040161737A1 (en) * | 2003-02-14 | 2004-08-19 | Yang Dan-Hui D. | Novel luminescent metal chelates and methods for their detection |
| KR101171253B1 (ko) * | 2003-12-24 | 2012-08-06 | 신이치로 이소베 | 생체분자의 검출방법 및 이에 사용하는 표지색소와표지키트 |
| JP3881667B2 (ja) | 2003-12-24 | 2007-02-14 | 信一郎 礒部 | 生体分子の検出方法及びそれに用いる標識色素並びに標識キット |
| WO2005083414A1 (ja) * | 2004-02-27 | 2005-09-09 | Hitachi High-Technologies Corporation | 試料の分析方法ならびに分析装置及び導入方法 |
| WO2006076650A2 (en) * | 2005-01-12 | 2006-07-20 | Applera Corporation | Compositions, methods, and kits for selective amplification of nucleic acids |
| JP5205062B2 (ja) * | 2005-02-10 | 2013-06-05 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 酸化還元活性構造体およびそれを利用するデバイス |
| WO2007013601A1 (ja) * | 2005-07-28 | 2007-02-01 | Shinichiro Isobe | 生体分子用標識色素及び標識キット並びに生体分子の検出方法 |
| JP2007232675A (ja) * | 2006-03-03 | 2007-09-13 | Matsushita Electric Ind Co Ltd | 遺伝子検出方法 |
| DK3467500T3 (da) * | 2011-11-11 | 2021-08-16 | Eli N Glezer | Cobinder-understøttede assayfremgangsmåder |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| EP2971183A4 (de) | 2013-03-13 | 2016-10-26 | Meso Scale Technologies Llc | Verbesserte testverfahren |
| WO2015070173A1 (en) * | 2013-11-08 | 2015-05-14 | Isis Pharmaceuticals, Inc. | Compounds and methods for detecting oligonucleotides |
| IL229525A0 (en) | 2013-11-20 | 2014-01-30 | Yeda Res & Dev | Metal complexes of tris-bipyridyl and their uses in electrochromic applications |
| KR20250011724A (ko) | 2014-05-15 | 2025-01-21 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| KR102601323B1 (ko) | 2015-08-20 | 2023-11-10 | 에프. 호프만-라 로슈 아게 | 페길화 분석물-특이적 결합제를 사용하는 입자-기반 면역어세이 |
| WO2017153336A1 (en) | 2016-03-07 | 2017-09-14 | F. Hoffmann-La Roche Ag | Detection of anti-p53 antibodies |
| CN120060564A (zh) * | 2016-09-07 | 2025-05-30 | 圣文森特医院悉尼有限公司 | 检测慢病毒的方法 |
| WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
| WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
| ES2983797T3 (es) | 2018-08-31 | 2024-10-24 | Hoffmann La Roche | Timidina cinasa (TK-1) en índices pronóstico para LDLBG |
| CN114144422B (zh) | 2019-03-01 | 2025-03-07 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| CN114144676A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a6作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| JP7315780B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスｐ |
| KR20220024782A (ko) | 2019-07-22 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a8 |
| JP7315781B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ１２ |
| BR112022000172A2 (pt) | 2019-07-22 | 2022-02-22 | Hoffmann La Roche | Métodos para avaliar se uma paciente tem endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente |
| JP7783809B2 (ja) | 2019-11-15 | 2025-12-10 | エフ． ホフマン－ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化 |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| JP7727015B2 (ja) | 2021-05-17 | 2025-08-20 | エフ． ホフマン－ラ ロシュ アーゲー | 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのｓＦＲＰ４ |
| EP4423122A1 (de) | 2021-10-26 | 2024-09-04 | F. Hoffmann-La Roche AG | Für sars-cov-2 rbd spezifische monoklonale antikörper |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| CN119404103A (zh) | 2022-06-23 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 用于诊断子宫内膜异位症及用于对子宫内膜异位症的分期进行分类的方法 |
| US20260036594A1 (en) | 2022-07-22 | 2026-02-05 | Roche Diagnostics Operations, Inc. | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| US20260016487A1 (en) | 2022-07-22 | 2026-01-15 | Roche Diagnostics Operations, Inc. | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| JP2025524025A (ja) | 2022-07-22 | 2025-07-25 | エフ． ホフマン－ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ） |
| CN121532654A (zh) | 2023-07-20 | 2026-02-13 | 豪夫迈·罗氏有限公司 | 针对抗体组合物的筛选方法 |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2788786B2 (ja) * | 1991-11-15 | 1998-08-20 | イゲン，インコーポレーテッド | 増幅生成物の迅速アッセイ |
| ZA929319B (en) * | 1991-12-11 | 1993-05-24 | Igen Inc | Method for exponential amplification of nucleic acid by a single unpaired primer. |
| DE4344742A1 (de) * | 1993-06-09 | 1994-12-15 | Boehringer Mannheim Gmbh | Verfahren zur Immobilisierung von Nukleinsäuren |
| ATE178946T1 (de) * | 1993-07-09 | 1999-04-15 | Akzo Nobel Nv | Verbessertes verfahren für die quantifizierung von nukleinsäuren |
| US5679519A (en) * | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
| US5925518A (en) * | 1995-05-19 | 1999-07-20 | Akzo Nobel N.V. | Nucleic acid primers for amplification of a mycobacteria RNA template |
-
1994
- 1994-09-21 EP EP94929300A patent/EP0722508B1/de not_active Expired - Lifetime
- 1994-09-21 DE DE69432419T patent/DE69432419T2/de not_active Expired - Fee Related
- 1994-09-21 AU AU78407/94A patent/AU700055B2/en not_active Ceased
- 1994-09-21 JP JP7509934A patent/JPH09505464A/ja not_active Withdrawn
- 1994-09-21 WO PCT/US1994/010732 patent/WO1995008644A1/en not_active Ceased
- 1994-09-21 CA CA002172248A patent/CA2172248C/en not_active Expired - Fee Related
- 1994-09-21 AT AT94929300T patent/ATE236269T1/de not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/474,927 patent/US6048687A/en not_active Expired - Fee Related
-
2001
- 2001-06-06 JP JP2001171226A patent/JP3502855B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3502855B2 (ja) | 2004-03-02 |
| AU700055B2 (en) | 1998-12-17 |
| WO1995008644A1 (en) | 1995-03-30 |
| US6048687A (en) | 2000-04-11 |
| EP0722508B1 (de) | 2003-04-02 |
| JPH09505464A (ja) | 1997-06-03 |
| CA2172248C (en) | 2003-12-30 |
| EP0722508A4 (de) | 1999-08-11 |
| JP2002034561A (ja) | 2002-02-05 |
| CA2172248A1 (en) | 1995-03-30 |
| DE69432419D1 (de) | 2003-05-08 |
| DE69432419T2 (de) | 2004-01-08 |
| AU7840794A (en) | 1995-04-10 |
| EP0722508A1 (de) | 1996-07-24 |
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