ATE148456T1 - Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese - Google Patents

Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese

Info

Publication number: ATE148456T1
Authority: AT; Austria
Prior art keywords: glycolipid synthesis; deoxygalactonojirimycin; derivatives; inhibit; deoxygalactonojirimycin derivatives
Prior art date: 1993-05-13

Application number

AT94916021T

Other languages

English (en)

Inventor

Frances M Glycobiology I Platt

Parks Road South

Gabrielle R Neises

Raymond A Glycobiology In Dwek

Terry D Glycobiology I Butters

Original Assignee

Searle & Co

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-13

Filing date

1994-05-11

Publication date

1997-02-15

1993-05-13 Priority claimed from US08/061,645 external-priority patent/US5399567A/en

1994-05-11 Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE148456T1 publication Critical patent/ATE148456T1/de

Links

HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 title abstract 2
229930186217 Glycolipid Natural products 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
LXBIFEVIBLOUGU-DPYQTVNSSA-N migalastat Chemical class OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O LXBIFEVIBLOUGU-DPYQTVNSSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT94916021T 1993-05-13 1994-05-11 Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese ATE148456T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/061,645 US5399567A (en)	1993-05-13	1993-05-13	Method of treating cholera
US08/102,654 US6291657B1 (en)	1993-05-13	1993-08-05	Deoxygalactonojirimycin derivatives

Publications (1)

Publication Number	Publication Date
ATE148456T1 true ATE148456T1 (de)	1997-02-15

Family

ID=26741316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94916021T ATE148456T1 (de)	1993-05-13	1994-05-11	Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese

Country Status (11)

Country	Link
US (3)	US6291657B1 (de)
EP (1)	EP0698012B1 (de)
JP (1)	JP3636363B2 (de)
AT (1)	ATE148456T1 (de)
AU (1)	AU6783294A (de)
CA (1)	CA2159988C (de)
DE (1)	DE69401658T2 (de)
DK (1)	DK0698012T3 (de)
ES (1)	ES2097653T3 (de)
GR (1)	GR3022554T3 (de)
WO (1)	WO1994026714A1 (de)

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US5798366A (en) *	1993-05-13	1998-08-25	Monsanto Company	Method for treatment of CNS-involved lysosomal storage diseases
US6465488B1 (en)	1997-12-11	2002-10-15	Chancellor, Masters & Scholars Of The University Of Oxford	Inhibition of glycolipid biosynthesis
US6274597B1 (en)	1998-06-01	2001-08-14	Mount Sinai School Of Medicine Of New York University	Method of enhancing lysosomal α-Galactosidase A
WO2000029556A2 (en) *	1998-11-17	2000-05-25	The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Identification of glycosphingolipids that promote hiv-1 entry into cells
US6610703B1 (en)	1998-12-10	2003-08-26	G.D. Searle & Co.	Method for treatment of glycolipid storage diseases
GB9909066D0 (en) *	1999-04-20	1999-06-16	Oxford Glycosciences Uk Ltd	Therapies
GB0100889D0 (en) *	2001-01-12	2001-02-21	Oxford Glycosciences Uk Ltd	Compounds
US20050032841A1 (en) *	1999-04-20	2005-02-10	Steven Walkley	Therapeutic compositions and methods of treating glycolipid storage related disorders
AU6050600A (en)	1999-07-26	2001-02-13	G.D. Searle & Co.	Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases
HK1046869A1 (zh)	1999-08-10	2003-01-30	The Chancellor, Masters And Scholars Of The University Of Oxford	使用长链n烷基化合物及其恶衍生物作为抗病毒成分
US7256005B2 (en)	1999-08-10	2007-08-14	The Chancellor, Masters And Scholars Of The University Of Oxford	Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
JP4585851B2 (ja)	2002-07-17	2010-11-24	アクテリオンファーマシューティカルズリミテッド	グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
EP1534676B1 (de)	2002-07-17	2012-09-12	Actelion Pharmaceuticals Ltd.	Piperidintriolderivate als inhibitoren von glycosylceramidsynthase
GB0229476D0 (en) *	2002-12-17	2003-01-22	Oxford Glycosciences Uk Ltd	Novel process
CN102586205A (zh)	2003-01-31	2012-07-18	纽约大学西奈山医学院	酶和酶的活性部位特异性陪伴分子的组合
GB0313677D0 (en)	2003-06-13	2003-07-16	Oxford Glycosciences Uk Ltd	Novel compound
GB0313678D0 (en)	2003-06-13	2003-07-16	Oxford Glycosciences Uk Ltd	Novel compounds
BRPI0416216A (pt) *	2003-11-12	2006-12-26	Amicus Therapeutics Inc	composto de glicoimidazol e polihidroxiciclohexenila e método para sintetizar composto de glicoimidazol e polihidroxiciclohexenila, métodos para inibir glicocerebrosidase, para aumentar a atividade de glicocerebrosidase e para estabilizar glicocerebrosidade, composição farmacêutica, métodos para inibir uma -glicosidade, e para tratar doença de gaucher, derivado de glicoimidazol e derivados de polihidroxiciclohexilamina
US20050256168A1 (en) *	2004-04-28	2005-11-17	Block Timothy M	Compositions for oral administration for the treatment of interferon-responsive disorders
US20090111812A1 (en) *	2004-06-14	2009-04-30	Musc Foundation For Research Development	Methods for treating inflammatory disorders
EP3782655A1 (de)	2005-05-17	2021-02-24	Amicus Therapeutics, Inc.	Verfahren zur behandlung der pompe-krankheit unter verwendung von 1-deoxynojirimycin und derivaten
GB0614947D0 (en) *	2006-07-27	2006-09-06	Isis Innovation	Epitope reduction therapy
KR20090040906A (ko) *	2006-08-02	2009-04-27	유나이티드 세러퓨틱스 코오포레이션	바이러스 감염의 리포솜 치료
WO2009118658A2 (en) *	2008-03-26	2009-10-01	University Of Oxford	Endoplasmic reticulum targeting liposomes
EP2410989A2 (de) *	2009-03-27	2012-02-01	The Chancellor, Masters and Scholars of the University of Oxford	Liposome zur senkung des cholesterinspiegels
CA2793276A1 (en) *	2009-03-27	2010-09-30	Zacharon Pharmaceuticals, Inc.	Ganglioside biosynthesis modulators
TWI572609B (zh)	2010-12-23	2017-03-01	默沙東藥廠	選擇性醣苷酶抑制劑及其用途
EP2691407B1 (de)	2011-03-31	2017-02-22	Alectos Therapeutics Inc.	Selektive glycosidasehemmer und ihre verwendung
US9701693B2 (en)	2011-06-27	2017-07-11	Alectos Therapeutics Inc.	Selective glycosidase inhibitors and uses thereof
EP2890675A4 (de)	2012-08-31	2016-01-13	Alectos Therapeutics Inc	Glycosidasehemmer und verwendungen davon
WO2014032187A1 (en) *	2012-08-31	2014-03-06	Alectos Therapeutics Inc.	Glycosidase inhibitors and uses thereof
WO2014032185A1 (en)	2012-08-31	2014-03-06	Alectos Therapeutics Inc.	Glycosidase inhibitors and uses thereof
RU2672873C2 (ru)	2012-10-31	2018-11-20	Алектос Терапьютикс Инк.	Ингибиторы гликозидаз и их применения
ES2779006T3 (es) *	2013-01-09	2020-08-13	Amicus Therapeutics Inc	Composiciones de DNJ parenterales estables
DK3630725T3 (da)	2017-06-01	2026-02-09	Idorsia Pharmaceuticals Ltd	Krystallinsk form af n-butyldeoxygalactonojirimycin
WO2021061701A1 (en)	2019-09-25	2021-04-01	Teva Pharmaceuticals International Gmbh	Solid state forms of lucerastat salts and process for preparation thereof
WO2022132992A1 (en)	2020-12-16	2022-06-23	Amicus Therapeutics, Inc.	Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds
US11623916B2 (en)	2020-12-16	2023-04-11	Amicus Therapeutics, Inc.	Highly purified batches of pharmaceutical grade migalastat and methods of producing the same
WO2025017212A1 (en)	2023-07-20	2025-01-23	Katholieke Universiteit Leuven	Udp-glucose ceramide glucosyltransferase synthase (ugcg) inhibitors in the treatment of cancer

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US4065562A (en)	1975-12-29	1977-12-27	Nippon Shinyaku Co., Ltd.	Method and composition for reducing blood glucose levels
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GB2020278B (en)	1978-05-03	1983-02-23	Nippon Shinyaku Co Ltd	Moranoline dervitives
ATE126696T1 (de)	1985-12-23	1995-09-15	Hutchinson Fred Cancer Res	Regulierung der retroviralen replikation, infektion und pathogenese.
US4849430A (en)	1988-03-09	1989-07-18	Monsanto Company	Method of inhibiting virus
US5011829A (en) *	1989-06-02	1991-04-30	G. D. Searle & Co.	Pharmaceutical composition and method of inhibiting virus
US5030638A (en)	1990-02-26	1991-07-09	G. D. Searle & Co.	Method of antiviral enhancement
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US5128347A (en) *	1990-10-18	1992-07-07	Monsanto Company	Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin

1993
- 1993-08-05 US US08/102,654 patent/US6291657B1/en not_active Expired - Lifetime
1994
- 1994-05-11 WO PCT/US1994/004974 patent/WO1994026714A1/en not_active Ceased
- 1994-05-11 AU AU67832/94A patent/AU6783294A/en not_active Abandoned
- 1994-05-11 CA CA002159988A patent/CA2159988C/en not_active Expired - Fee Related
- 1994-05-11 DK DK94916021.2T patent/DK0698012T3/da active
- 1994-05-11 ES ES94916021T patent/ES2097653T3/es not_active Expired - Lifetime
- 1994-05-11 DE DE69401658T patent/DE69401658T2/de not_active Expired - Fee Related
- 1994-05-11 EP EP94916021A patent/EP0698012B1/de not_active Expired - Lifetime
- 1994-05-11 JP JP52554194A patent/JP3636363B2/ja not_active Expired - Fee Related
- 1994-05-11 AT AT94916021T patent/ATE148456T1/de not_active IP Right Cessation
1995
- 1995-03-01 US US08/396,989 patent/US5580884A/en not_active Expired - Lifetime
1996
- 1996-01-17 US US08/588,027 patent/US5786368A/en not_active Expired - Fee Related
1997
- 1997-02-12 GR GR970400244T patent/GR3022554T3/el unknown

Also Published As

Publication number	Publication date
DK0698012T3 (de)	1997-02-17
CA2159988C (en)	2007-01-09
US5580884A (en)	1996-12-03
GR3022554T3 (en)	1997-05-31
WO1994026714A1 (en)	1994-11-24
JP3636363B2 (ja)	2005-04-06
AU6783294A (en)	1994-12-12
EP0698012A1 (de)	1996-02-28
US6291657B1 (en)	2001-09-18
US5786368A (en)	1998-07-28
DE69401658T2 (de)	1997-06-12
CA2159988A1 (en)	1994-11-24
ES2097653T3 (es)	1997-04-01
EP0698012B1 (de)	1997-01-29
JPH08510244A (ja)	1996-10-29
DE69401658D1 (de)	1997-03-13

Legal Events

Date	Code	Title	Description
1997-11-15	UEP	Publication of translation of european patent specification
2010-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE148456T1 (de)	1997-02-15	Verwendung von deoxygalactonojirimycin derivaten zu hemmung der glycolipid synthese
ATE196140T1 (de)	2000-09-15	Substituierte benzylaminoquinuclidine als substanz p antagonisten
YU64092A (sh)	1995-03-27	Fluoralkoksibenzamino derivati heterocikličnih jedinjenja koja sadrže azot
MY108659A (en)	1996-10-31	Pesticidal 1-(2-pyridyl) pyrazoles
DK0915866T3 (da)	2002-06-10	Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre
DE69133299D1 (de)	2003-09-04	Aminosulfonylcarbamate
DE3688559D1 (de)	1993-07-15	Zwischenprodukte in der synthese von diaminandrostan-derivaten.
ES447509A1 (es)	1977-07-01	Perfeccionamientos en amortiguadores-distanciadores para ca-bles suspendidos.
ES8504211A1 (es)	1985-04-16	Procedimiento para la preparacion de derivados de oligoglucosido
MX9301045A (es)	1993-09-01	Procedimiento para preparar antagonistas receptores de fibrinogeno.
MX9400194A (es)	1994-07-29	Materiales fototermograficos.
HU9500559D0 (en)	1995-04-28	New mercapto-acetamide tricyclic derivatives as enkephalinase-inhibitors
TR199800243T1 (xx)	1998-06-22	Prolil endopeptidaz inhibit�rleri.
ATE167664T1 (de)	1998-07-15	Verwendung von aminen in ölzusammensetzungen
ATE196464T1 (de)	2000-10-15	Benzol-derivate, verwendbar für ischämische erkrankungen
GB9513331D0 (en)	1995-09-06	Matrix metalloproteinase inhibitors
CA1273946C (en)	1990-09-11	ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES
GB2341862A (en)	2000-03-29	Histamine H3 receptor ligands
ATE159934T1 (de)	1997-11-15	Azoxycyanobenzol-derivate und ihre verwendung als fungizide
GB1512620A (en)	1978-06-01	Derivatives of dithiepino(1,4)(2,3-c)pyrrole
ES2192342T3 (es)	2003-10-01	2-(2,6-dioxo-3-fluoropiperidin-3-il)-isoindolinas sustituidas y su uso para reducir los niveles de tnfalfa.
DK0850217T3 (da)	2000-09-11	Fremgangsmåde til fremstilling af arylalkynyl-N-hydroxy-carbamid-derivater med lipoxygenaseinhibitor-aktivitet
DK0705266T3 (da)	1997-09-01	Fremgangsmåde til fremstilling af et imidazolderivat.
TW333554B (en)	1998-06-11	Benzidine derivative and electrophotosensitive material using the same
GB1216170A (en)	1970-12-16	N-substituted aryl carbmates