ATE148459T1 - Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften - Google Patents

Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften

Info

Publication number: ATE148459T1
Authority: AT; Austria
Prior art keywords: pct; cycloalkylbenzene; tetrahydroisoquinoline; spiro; date mar
Prior art date: 1990-08-24

Application number

AT91915049T

Other languages

English (en)

Inventor

Ronald Conrad Griffith

James Russell Matz

James Joseph Napier

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-24

Filing date

1991-08-19

Publication date

1997-02-15

1991-08-19 Application filed by Astra Ab filed Critical Astra Ab

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE148459T1 publication Critical patent/ATE148459T1/de

Links

230000000324 neuroprotective effect Effects 0.000 title 1
UWYZHKAOTLEWKK-UHFFFAOYSA-N tetrahydro-isoquinoline Natural products C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000000626 neurodegenerative effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT91915049T 1990-08-24 1991-08-19 Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften ATE148459T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57357590A	1990-08-24	1990-08-24

Publications (1)

Publication Number	Publication Date
ATE148459T1 true ATE148459T1 (de)	1997-02-15

Family

ID=24292556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91915049T ATE148459T1 (de)	1990-08-24	1991-08-19	Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften

Country Status (9)

Country	Link
US (1)	US5472968A (de)
EP (1)	EP0544748B1 (de)
JP (1)	JPH06500327A (de)
AT (1)	ATE148459T1 (de)
DE (1)	DE69124519T2 (de)
DK (1)	DK0544748T3 (de)
ES (1)	ES2099166T3 (de)
GR (1)	GR3023189T3 (de)
WO (1)	WO1992003420A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1487798A4 (de) *	2002-03-28	2005-07-13	Neurogen Corp	Substituierte tetrahydroisochinoline als c5a-rezeptor-modulatoren
RU2763738C1 (ru) *	2021-06-17	2021-12-30	Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ)	Применение 1-бензил-4'-гидрокси-1'-(2-гидроксиэтил)-3'-(метоксибензоил)-6,6-диметил-6,7-дигидроспиро[индол-3,2'-пиррол]2,4,5'(1H,1'H,5H)-триона в качестве средства, обладающего антигипоксической активностью

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3886163A (en) *	1967-06-28	1975-05-27	Pfizer	1,3(2H,4H)-dioxoisoquinoline-4-carboxamides

1991
- 1991-08-19 DE DE69124519T patent/DE69124519T2/de not_active Expired - Fee Related
- 1991-08-19 ES ES91915049T patent/ES2099166T3/es not_active Expired - Lifetime
- 1991-08-19 JP JP3514541A patent/JPH06500327A/ja active Pending
- 1991-08-19 US US07/975,932 patent/US5472968A/en not_active Expired - Fee Related
- 1991-08-19 WO PCT/US1991/005887 patent/WO1992003420A1/en not_active Ceased
- 1991-08-19 AT AT91915049T patent/ATE148459T1/de not_active IP Right Cessation
- 1991-08-19 DK DK91915049.0T patent/DK0544748T3/da active
- 1991-08-19 EP EP91915049A patent/EP0544748B1/de not_active Expired - Lifetime
1997
- 1997-04-21 GR GR970400849T patent/GR3023189T3/el unknown

Also Published As

Publication number	Publication date
EP0544748A1 (de)	1993-06-09
DE69124519D1 (de)	1997-03-13
DK0544748T3 (da)	1997-08-11
WO1992003420A1 (en)	1992-03-05
GR3023189T3 (en)	1997-07-30
US5472968A (en)	1995-12-05
ES2099166T3 (es)	1997-05-16
EP0544748B1 (de)	1997-01-29
DE69124519T2 (de)	1997-06-12
JPH06500327A (ja)	1994-01-13

Legal Events

Date	Code	Title	Description
1997-08-15	UEP	Publication of translation of european patent specification
1999-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE220677T1 (de)	2002-08-15	Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung
DK0674624T3 (da)	1999-09-13	Pyrazoler med CRF-antagonistisk aktivitet
DK0589924T3 (da)	1996-09-30	Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser
CA2176935A1 (fr)	1995-05-26	Arylpiperazines derivees d'indole comme ligands pour les recepteurs 5 ht1-like 5 ht1b et 5 ht1d
IL140070A0 (en)	2002-02-10	Benzamide derivatives and pharmaceutical compositions containing the same
DE69330612D1 (de)	2001-09-20	Neue pyridon carbonsäure-derivate
ATE168105T1 (de)	1998-07-15	Melamine derivate zur verwendung in der behandlung von krebs
DE69130326D1 (de)	1998-11-12	Piperidin-verbindungen, ihre darstellung und ihre verwendung
MX9203100A (es)	1993-07-01	Nuevos peptidos, su preparacion y su aplicacion.
FI923679A0 (fi)	1992-08-17	Ny b-fenylisoserinderivat, dess framstaellning och anvaendning.
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
ATE148459T1 (de)	1997-02-15	Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften
MX9303605A (es)	1993-12-01	Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
ATE163402T1 (de)	1998-03-15	Substituierte ortho- ethenylphenylessigsäurederivate
ES2060401T3 (es)	1994-11-16	Nuevos derivados de estroptograminas y su preparacion.
ATE154010T1 (de)	1997-06-15	2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften
GB9304632D0 (en)	1993-04-21	Amide derivatives
DK0651747T3 (da)	1996-05-20	Carbostyrilderivater
ATE145135T1 (de)	1996-11-15	Verwendung von riluzol zum schutz gegen strahlenschäden