ES2099166T3 - Espiro(cicloalquilbenceno-1,1'-(1',2',3',4'-tetrahidroisoquinoleinas)) que tienen propiedades neuroprotectoras. - Google Patents

Espiro(cicloalquilbenceno-1,1'-(1',2',3',4'-tetrahidroisoquinoleinas)) que tienen propiedades neuroprotectoras.

Info

Publication number
ES2099166T3
ES2099166T3 ES91915049T ES91915049T ES2099166T3 ES 2099166 T3 ES2099166 T3 ES 2099166T3 ES 91915049 T ES91915049 T ES 91915049T ES 91915049 T ES91915049 T ES 91915049T ES 2099166 T3 ES2099166 T3 ES 2099166T3
Authority
ES
Spain
Prior art keywords
compounds
properties
tetrahydroisokinoleins
neuroprotectoral
cyclloalkylbenzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915049T
Other languages
English (en)
Inventor
Ronald Conrad Griffith
James Russell Matz
James Joseph Napier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2099166T3 publication Critical patent/ES2099166T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) EN LA QUE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O ALQUIL C1-C6, R3 Y R4 REPRESENTAN INDEPENDIENTEMENTE UNO O MAS RADICALES SELECCIONADOS ENTRE HIDROGENO, OH, NH2, NO2, HALOGENO, ALQUIL C1-C6 O ALCOXIDO C1-C6 Y N ES UN ENTERO ENTRE 1 Y 2 AMBOS INCLUSIVE, ASIMISMO SE PRESENTAN LOS DERIVADOS FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS QUE SON UTILES COMO PRODUCTOS FARMACEUTICOS; EN PARTICULAR, LOS COMPUESTOS POSEEN PROPIEDADES BLOQUEADORAS DEL N-METIL-(D)-ASPARTATO (NMDA) Y SON UTILES EN EL TRATAMIENTO Y/O PREVENCION DE CONDICIONES NEURODEGENERATIVAS.
ES91915049T 1990-08-24 1991-08-19 Espiro(cicloalquilbenceno-1,1'-(1',2',3',4'-tetrahidroisoquinoleinas)) que tienen propiedades neuroprotectoras. Expired - Lifetime ES2099166T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57357590A 1990-08-24 1990-08-24

Publications (1)

Publication Number Publication Date
ES2099166T3 true ES2099166T3 (es) 1997-05-16

Family

ID=24292556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915049T Expired - Lifetime ES2099166T3 (es) 1990-08-24 1991-08-19 Espiro(cicloalquilbenceno-1,1'-(1',2',3',4'-tetrahidroisoquinoleinas)) que tienen propiedades neuroprotectoras.

Country Status (9)

Country Link
US (1) US5472968A (es)
EP (1) EP0544748B1 (es)
JP (1) JPH06500327A (es)
AT (1) ATE148459T1 (es)
DE (1) DE69124519T2 (es)
DK (1) DK0544748T3 (es)
ES (1) ES2099166T3 (es)
GR (1) GR3023189T3 (es)
WO (1) WO1992003420A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082828A1 (en) * 2002-03-28 2003-10-09 Neurogen Corporation Substituted tetrahydroisoquinolines as c5a receptor modulators
RU2763738C1 (ru) * 2021-06-17 2021-12-30 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 1-бензил-4'-гидрокси-1'-(2-гидроксиэтил)-3'-(метоксибензоил)-6,6-диметил-6,7-дигидроспиро[индол-3,2'-пиррол]2,4,5'(1H,1'H,5H)-триона в качестве средства, обладающего антигипоксической активностью

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886163A (en) * 1967-06-28 1975-05-27 Pfizer 1,3(2H,4H)-dioxoisoquinoline-4-carboxamides

Also Published As

Publication number Publication date
US5472968A (en) 1995-12-05
DE69124519D1 (de) 1997-03-13
EP0544748A1 (en) 1993-06-09
GR3023189T3 (en) 1997-07-30
EP0544748B1 (en) 1997-01-29
ATE148459T1 (de) 1997-02-15
DE69124519T2 (de) 1997-06-12
WO1992003420A1 (en) 1992-03-05
DK0544748T3 (da) 1997-08-11
JPH06500327A (ja) 1994-01-13

Similar Documents

Publication Publication Date Title
MXPA01004256A (es) N-arilamidas del acido antranilico y del acido tioantranilico.
DE69923849D1 (de) Quinolin-2-on-derivate verwendbar als antikrebsmittel
TR200201430T2 (tr) Antiproliferatif maddeler olarak faydalı yeni benzoimidazol türevleri.
DE69529670D1 (de) Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen
ATE184598T1 (de) Enniatine und enniatinderivate zur bekämpfung von endoparasiten
SE9001329L (sv) Adamantanderivat foer att foerhindra och behandla cerebral ischemi
ES2188584T3 (es) Derivados heterociclicos de amina.
ATE148610T1 (de) Antimikrobielle mittel sowie substituierte 2- cyclohexan-1-yl-amin-derivate und deren herstellung
YU95102A (sh) Supstituisani biciklični derivati u lečenju abnormalnog rasta ćelija
GEP20033001B (en) Alkynyl-Substituted Quinolin-2-One Derivatives Useful As Anticancer Agents
TR200003478T2 (tr) Antikanser maddeleri olarak faydalı izotiyazol türevleri
MY132872A (en) Benzimidazole derivatives.
EA200500174A1 (ru) Новые производные бензимидазола, полезные в качестве антипролиферативных агентов
NO912859L (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzimidazoler.
ES2055860T3 (es) Derivados 2-aminopirimidinona.
YU55602A (sh) Amino derivati dihidro-1,3,5-triazina i njihova terapeutska primena
PT95584A (pt) Processo de preparacao de antraquinonas, dos seus intermediarios e de composicoes farmaceuticas
AP2001002302A0 (en) 13-Methyl erythromycin derivatives.
ES2160602T3 (es) Derivados de quinolona y acridinona para el tratamiento de la incontinencia urinaria.
ATE180781T1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
ATE73790T1 (de) Amino 5,6,7,8tetrahydronaphtho(2,3b>furanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
AR007108A1 (es) Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.
FI930171A0 (fi) Piperidinfoereningar, framstaellning och anvaendning av dessa
ATE247964T1 (de) Als inhibitoren der aicarftnützliche verbindungen
DE69933885D1 (de) Triphenylbutenderivate zur behandlung von neurologischen störungen

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 544748

Country of ref document: ES