ATE149523T1 - Verfahren zur herstellung von interferon-alpha-2 kristallen - Google Patents

Verfahren zur herstellung von interferon-alpha-2 kristallen

Info

Publication number: ATE149523T1
Authority: AT; Austria
Prior art keywords: crystals; interferon alpha; producing interferon; producing; zinc
Prior art date: 1990-06-04

Application number

AT91911595T

Other languages

English (en)

Inventor

Paul Reichert

Gerald S Hammond

Hung V Le

Tattanahalli L Nagabhushan

Paul P Trotta

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-04

Filing date

1991-06-03

Publication date

1997-03-15

1991-06-03 Application filed by Schering Corp filed Critical Schering Corp

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149523T1 publication Critical patent/ATE149523T1/de

Links

108010078049 Interferon alpha-2 Proteins 0.000 title abstract 2
102100039350 Interferon alpha-7 Human genes 0.000 title abstract 2
239000013078 crystal Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

AT91911595T 1990-06-04 1991-06-03 Verfahren zur herstellung von interferon-alpha-2 kristallen ATE149523T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53322590A	1990-06-04	1990-06-04

Publications (1)

Publication Number	Publication Date
ATE149523T1 true ATE149523T1 (de)	1997-03-15

Family

ID=24125036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911595T ATE149523T1 (de)	1990-06-04	1991-06-03	Verfahren zur herstellung von interferon-alpha-2 kristallen

Country Status (24)

Country	Link
US (2)	US5460956A (de)
EP (1)	EP0597851B1 (de)
JP (1)	JPH0749440B2 (de)
CN (2)	CN1033035C (de)
AT (1)	ATE149523T1 (de)
AU (1)	AU636043B2 (de)
CA (1)	CA2084406A1 (de)
DE (1)	DE69125035T2 (de)
ES (1)	ES2098358T3 (de)
FI (1)	FI925515A7 (de)
HU (1)	HUT63185A (de)
IE (1)	IE911892A1 (de)
IL (1)	IL98354A0 (de)
MX (1)	MX9203319A (de)
MY (1)	MY107450A (de)
NO (1)	NO924672L (de)
NZ (1)	NZ238384A (de)
OA (1)	OA09720A (de)
PL (1)	PL166045B1 (de)
PT (1)	PT97849A (de)
SG (1)	SG45207A1 (de)
TW (1)	TW342395B (de)
WO (1)	WO1991018927A1 (de)
ZA (1)	ZA914200B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5912015A (en) *	1992-03-12	1999-06-15	Alkermes Controlled Therapeutics, Inc.	Modulated release from biocompatible polymers
US5711968A (en) *	1994-07-25	1998-01-27	Alkermes Controlled Therapeutics, Inc.	Composition and method for the controlled release of metal cation-stabilized interferon
SE9302278D0 (sv) *	1992-10-28	1993-07-02	Kabi Pharmacia Ab	Growth hormone
US5441734A (en) *	1993-02-25	1995-08-15	Schering Corporation	Metal-interferon-alpha crystals
AU706180B2 (en) *	1994-07-25	1999-06-10	Alkermes Controlled Therapeutics, Inc.	Controlled release of metal cation-stabilized interferon
AU710347B2 (en) *	1995-08-31	1999-09-16	Alkermes Controlled Therapeutics, Inc.	Composition for sustained release of an agent
US5972331A (en) *	1995-12-22	1999-10-26	Schering Corporation	Crystalline interferon alpha for pulmonary delivery and method for producing the same
US6392069B2 (en)	1996-01-08	2002-05-21	Canji, Inc.	Compositions for enhancing delivery of nucleic acids to cells
US20100251425A9 (en) *	1998-05-15	2010-09-30	University Of Central Florida	Expression of human interferon in transgenic chloroplasts
US6281337B1 (en)	1998-11-12	2001-08-28	Schering Corporation	Methods for conversion of protein isoforms
DE19859876A1 (de)	1998-12-23	2000-06-29	Fraunhofer Ges Forschung	Verfahren zur Kristallisation aus Lösungen
US6465425B1 (en)	2000-02-10	2002-10-15	Alkermes Controlled Therapeutics, Inc.	Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
ES2358416T3 (es) *	2001-10-30	2011-05-10	Novartis Ag	Formulaciones de liberación prolongada de iloperidona y polímero en forma de estrella.
GB0216416D0 (en)	2002-07-15	2002-08-21	Novartis Ag	Organic compounds
CA2498319A1 (en) *	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
JP2006523609A (ja) *	2002-12-31	2006-10-19	アルタスファーマシューティカルズインコーポレイテッド	タンパク質結晶およびイオン性ポリマーの複合体
CA2512052C (en)	2002-12-31	2016-06-21	Altus Pharmaceuticals Inc.	Human growth hormone crystals and methods for preparing them
CN103755800B (zh)	2004-02-02	2016-02-24	Ambrx公司	经修饰的人类生长激素多肽与其用途
US8679472B1 (en)	2006-10-05	2014-03-25	Merck, Sharp & Dohme Corp.	Crystal of human interferon alpha 2B in complex with zinc
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
US20110027229A1 (en)	2009-07-31	2011-02-03	Medtronic, Inc.	Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
US20160303242A1 (en)	2013-12-09	2016-10-20	Durect Corporation	Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2882203A (en) *	1951-06-26	1959-04-14	Novo Terapeutisk Labor As	Injectable insulin preparation with protracted effect
US2822203A (en) *	1955-02-17	1958-02-04	Gen Motors Corp	Door latch and control means
US4315852A (en) *	1980-11-26	1982-02-16	Schering Corporation	Extraction of interferon from bacteria
US4672108A (en) *	1981-12-07	1987-06-09	Hoffmann-La Roche Inc.	Crystalline human leukocyte interferon
US4853218A (en) *	1987-02-24	1989-08-01	Schering Corporation	Zinc-protamine-alpha interferon complex
US5441734A (en) *	1993-02-25	1995-08-15	Schering Corporation	Metal-interferon-alpha crystals

1991
- 1991-06-03 HU HU923828A patent/HUT63185A/hu unknown
- 1991-06-03 MX MX9203319A patent/MX9203319A/es not_active Application Discontinuation
- 1991-06-03 MY MYPI91000969A patent/MY107450A/en unknown
- 1991-06-03 ZA ZA914200A patent/ZA914200B/xx unknown
- 1991-06-03 CA CA002084406A patent/CA2084406A1/en not_active Abandoned
- 1991-06-03 AT AT91911595T patent/ATE149523T1/de not_active IP Right Cessation
- 1991-06-03 DE DE69125035T patent/DE69125035T2/de not_active Expired - Fee Related
- 1991-06-03 IL IL98354A patent/IL98354A0/xx unknown
- 1991-06-03 WO PCT/US1991/003660 patent/WO1991018927A1/en not_active Ceased
- 1991-06-03 AU AU79552/91A patent/AU636043B2/en not_active Ceased
- 1991-06-03 SG SG1996001280A patent/SG45207A1/en unknown
- 1991-06-03 FI FI925515A patent/FI925515A7/fi not_active Application Discontinuation
- 1991-06-03 PL PL91297182A patent/PL166045B1/pl unknown
- 1991-06-03 ES ES91911595T patent/ES2098358T3/es not_active Expired - Lifetime
- 1991-06-03 JP JP3510285A patent/JPH0749440B2/ja not_active Expired - Lifetime
- 1991-06-03 EP EP91911595A patent/EP0597851B1/de not_active Expired - Lifetime
- 1991-06-03 PT PT97849A patent/PT97849A/pt not_active Application Discontinuation
- 1991-06-03 US US07/952,840 patent/US5460956A/en not_active Expired - Fee Related
- 1991-06-04 CN CN91103687A patent/CN1033035C/zh not_active Expired - Fee Related
- 1991-06-04 NZ NZ238384A patent/NZ238384A/en unknown
- 1991-06-04 TW TW080104341A patent/TW342395B/zh active
- 1991-06-04 IE IE189291A patent/IE911892A1/en not_active IP Right Cessation
1992
- 1992-12-03 NO NO92924672A patent/NO924672L/no unknown
- 1992-12-03 OA OA60314A patent/OA09720A/en unknown
1995
- 1995-06-06 US US08/469,332 patent/US5741485A/en not_active Expired - Fee Related
- 1995-12-09 CN CN95121315A patent/CN1044709C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1132212A (zh)	1996-10-02
HUT63185A (en)	1993-07-28
FI925515A0 (fi)	1992-12-04
IE911892A1 (en)	1991-12-04
CN1058022A (zh)	1992-01-22
US5741485A (en)	1998-04-21
AU7955291A (en)	1991-12-31
MX9203319A (es)	1992-07-31
EP0597851B1 (de)	1997-03-05
CN1033035C (zh)	1996-10-16
JPH05503292A (ja)	1993-06-03
OA09720A (en)	1993-08-30
PL166045B1 (pl)	1995-03-31
DE69125035T2 (de)	1997-07-10
EP0597851A1 (de)	1994-05-25
FI925515L (fi)	1992-12-04
DE69125035D1 (de)	1997-04-10
IL98354A0 (en)	1992-07-15
NZ238384A (en)	1992-11-25
CA2084406A1 (en)	1991-12-05
AU636043B2 (en)	1993-04-08
NO924672D0 (no)	1992-12-03
NO924672L (no)	1992-12-03
ZA914200B (en)	1992-03-25
WO1991018927A1 (en)	1991-12-12
PT97849A (pt)	1992-03-31
ES2098358T3 (es)	1997-05-01
US5460956A (en)	1995-10-24
CN1044709C (zh)	1999-08-18
TW342395B (en)	1998-10-11
MY107450A (en)	1995-12-30
FI925515A7 (fi)	1992-12-04
HU9203828D0 (en)	1993-03-29
SG45207A1 (en)	1998-01-16
JPH0749440B2 (ja)	1995-05-31

Legal Events

Date	Code	Title	Description
1997-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69125035D1 (de)	1997-04-10	Verfahren zur herstellung von interferon-alpha-2 kristallen
DE69110475D1 (de)	1995-07-20	Verfahren zur herstellung von perfluorolefinen.
DE68923805D1 (de)	1995-09-14	Verfahren zur herstellung von optisch aktivem 1,3-butanediol.
DE68910941D1 (de)	1994-01-05	Verfahren zur herstellung von hydroxylapatit.
DE69020586D1 (de)	1995-08-03	Verfahren zur herstellung von 1-okten.
DE69110037D1 (de)	1995-06-29	Verfahren zur herstellung von perfluoropolyethern.
DE59002322D1 (de)	1993-09-16	Verfahren zur herstellung von 1,1,1,3,3,3-hexafluorpropan und 2-chlor-1,1,1,3,3,3-hexafluorpropan.
DE69111064D1 (de)	1995-08-10	Verfahren zur herstellung von perfluoralkylethylalkoholen.
DE69007418D1 (de)	1994-04-21	Octadienyläther und verfahren zur herstellung von octadienyläthern.
DE3888523D1 (de)	1994-04-21	Verfahren zur herstellung von 4,4'-dibromdiphenylether.
DE69105273D1 (de)	1995-01-05	Verfahren zur herstellung von selbstklebefolien.
DE68900211D1 (de)	1991-09-26	Verfahren zur herstellung von 4,4'-dihydroxydiphenylmethan.
DE68906500D1 (de)	1993-06-17	Verfahren zur herstellung von 2,6-dimethylnaphthalin.
DE58903458D1 (de)	1993-03-18	Verfahren zur herstellung von 1,5-dihydroxy- und 1,5 diaminonaphthalin.
DE69314480D1 (de)	1997-11-13	Verfahren zur herstellung von 1,1,1,2,2,4,4,5,5,5,-decafluorpentan
DE3766046D1 (de)	1990-12-13	Verfahren zur herstellung von isopropylakohol und tertiaeren c4-bis c5-alkoholen.
DE58901624D1 (de)	1992-07-16	Verfahren zur herstellung von fluorbenzolen.
DE58902932D1 (de)	1993-01-21	Verfahren zur herstellung von 2-hydroxy-4-(2'-hydroxyethoxy)-benzophenonen.
DE68913959D1 (de)	1994-04-21	Verfahren zur herstellung von eisen-bor-silizium legierung.
DE68907180D1 (de)	1993-07-22	Verfahren zur herstellung von 2,3,5-trimethylbenzochinon.
DE68901576D1 (de)	1992-06-25	Verfahren zur herstellung von 2,3,5-trimethylbenzochinon.
DE69107086D1 (de)	1995-03-09	Verfahren zur herstellung von glycosylphosphattriestern.
DE69532533D1 (de)	2004-03-11	Verfahren zur herstellung von ranitidin
DE58903809D1 (de)	1993-04-22	Verfahren zur herstellung von 4,4'-dinitrodiphenylamin.
DE59106058D1 (de)	1995-08-24	Verfahren zur herstellung von 2,3-difluor-6-nitrophenol.