ATE80660T1 - Verfahren zur herstellung eines polypeptides. - Google Patents

Verfahren zur herstellung eines polypeptides.

Info

Publication number
ATE80660T1
ATE80660T1 AT87902674T AT87902674T ATE80660T1 AT E80660 T1 ATE80660 T1 AT E80660T1 AT 87902674 T AT87902674 T AT 87902674T AT 87902674 T AT87902674 T AT 87902674T AT E80660 T1 ATE80660 T1 AT E80660T1
Authority
AT
Austria
Prior art keywords
pct
polypeptide
secretion sequence
production
terminal secretion
Prior art date
Application number
AT87902674T
Other languages
English (en)
Inventor
Ian Barry Holland
Nigel Mackman
Jean-Marc Nicaud
Original Assignee
Ian Barry Holland
Nigel Mackman
Nicaud Jean Marc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ian Barry Holland, Nigel Mackman, Nicaud Jean Marc filed Critical Ian Barry Holland
Application granted granted Critical
Publication of ATE80660T1 publication Critical patent/ATE80660T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT87902674T 1986-05-15 1987-05-14 Verfahren zur herstellung eines polypeptides. ATE80660T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB868611832A GB8611832D0 (en) 1986-05-15 1986-05-15 Polypeptide
PCT/GB1987/000331 WO1987006953A1 (en) 1986-05-15 1987-05-14 Process for the production of a polypeptide
EP87902674A EP0267224B1 (de) 1986-05-15 1987-05-14 Verfahren zur herstellung eines polypeptides

Publications (1)

Publication Number Publication Date
ATE80660T1 true ATE80660T1 (de) 1992-10-15

Family

ID=10597902

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87902674T ATE80660T1 (de) 1986-05-15 1987-05-14 Verfahren zur herstellung eines polypeptides.

Country Status (9)

Country Link
US (1) US5143830A (de)
EP (1) EP0267224B1 (de)
JP (1) JPS63503274A (de)
AT (1) ATE80660T1 (de)
AU (1) AU600949B2 (de)
DE (1) DE3781765T2 (de)
DK (1) DK13788A (de)
GB (2) GB8611832D0 (de)
WO (1) WO1987006953A1 (de)

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DE3781765T2 (de) 1993-04-22
AU7392387A (en) 1987-12-01
JPS63503274A (ja) 1988-12-02
DE3781765D1 (de) 1992-10-22
EP0267224B1 (de) 1992-09-16
GB2197324A (de) 1988-05-18
DK13788A (da) 1988-03-15
DK13788D0 (da) 1988-01-13
GB8611832D0 (en) 1986-06-25
EP0267224A1 (de) 1988-05-18
GB8800141D0 (en) 1988-03-02
AU600949B2 (en) 1990-08-30
GB2197324B (en) 1990-04-11
US5143830A (en) 1992-09-01
WO1987006953A1 (en) 1987-11-19

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