ATE150320T1 - Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure - Google Patents

Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure

Info

Publication number
ATE150320T1
ATE150320T1 AT94307259T AT94307259T ATE150320T1 AT E150320 T1 ATE150320 T1 AT E150320T1 AT 94307259 T AT94307259 T AT 94307259T AT 94307259 T AT94307259 T AT 94307259T AT E150320 T1 ATE150320 T1 AT E150320T1
Authority
AT
Austria
Prior art keywords
alginate
agents
polyacrylic acid
interaction
consolidated
Prior art date
Application number
AT94307259T
Other languages
English (en)
Inventor
W R Gombotz
R J Mumper
L S Bouchard
A S Hoffman
Original Assignee
Bristol Myers Squibb Co
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Univ Washington filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE150320T1 publication Critical patent/ATE150320T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
AT94307259T 1993-10-15 1994-10-04 Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure ATE150320T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/138,367 US5451411A (en) 1993-10-15 1993-10-15 Methods and compositions for the oral delivery of therapeutic agents

Publications (1)

Publication Number Publication Date
ATE150320T1 true ATE150320T1 (de) 1997-04-15

Family

ID=22481704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94307259T ATE150320T1 (de) 1993-10-15 1994-10-04 Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure

Country Status (9)

Country Link
US (1) US5451411A (de)
EP (1) EP0652015B1 (de)
JP (1) JPH07258115A (de)
AT (1) ATE150320T1 (de)
CA (1) CA2133271A1 (de)
DE (1) DE69402153T2 (de)
DK (1) DK0652015T3 (de)
ES (1) ES2100632T3 (de)
GR (1) GR3023307T3 (de)

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GB9619660D0 (en) * 1996-09-20 1996-11-06 Scient Hospital Suppl Int Ltd Prevention of gastrointestinal damage
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
JP2002500201A (ja) * 1998-01-05 2002-01-08 ユニバーシティ オブ ワシントン 膜破壊剤を使用する増強された輸送
GB9806530D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
JP2002527408A (ja) 1998-10-09 2002-08-27 ミシガン大学 ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー
JP2002539172A (ja) 1999-03-17 2002-11-19 ノバルティス アクチエンゲゼルシャフト Ｔｇｆ−ベータを含む医薬組成物
WO2001024812A1 (en) * 1999-10-06 2001-04-12 N.V. Nutricia USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA
US7737108B1 (en) 2000-01-07 2010-06-15 University Of Washington Enhanced transport using membrane disruptive agents
US6596310B1 (en) 2000-08-23 2003-07-22 Board Of Trustees Operating Michigan State University Method of artificial insemination by timed release of sperm from capsules or solid beads
US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
US20030206957A1 (en) * 2002-05-06 2003-11-06 Scherr George H. Orally administered medicament delivery systems
EP1592970A4 (de) * 2003-02-11 2007-09-19 Univ Washington Auf reize reagierende polymerkonjugate und damit verbundene verfahren
JP4822092B2 (ja) * 2003-09-01 2011-11-24 大正製薬株式会社 Ｗ／ｏ／ｗ型複合エマルション
DE10350248A1 (de) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
US7744895B2 (en) * 2005-08-31 2010-06-29 Yamanashi University Methods of treating allergies using TGF-β1 and allergens
WO2007109584A1 (en) * 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
US8178130B2 (en) 2006-07-04 2012-05-15 Elisabeth Kommisrud Preservation and controlled delivery / release of spermatozoa
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
US20080292663A1 (en) * 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
DE102007059939A1 (de) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen
IT1392471B1 (it) * 2008-11-25 2012-03-09 Pharmafilm S R L Collutorio in forma di sospensione stabile comprendente microsfere che incorporano un principio attivo.
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
EP2575891A4 (de) * 2010-06-03 2014-10-08 Rph Pharmaceuticals Ab Formulierungen zur aufrechterhaltung einer bioaktivität und verfahren zu ihrer herstellung
US9165703B2 (en) * 2010-08-25 2015-10-20 Brown University Methods and systems for prolonged localization of drug delivery
US20120213856A1 (en) * 2011-02-23 2012-08-23 Po-Lun Wang Manufacturing Method of Microcapsule
EP4218808A3 (de) 2012-03-12 2023-08-09 Advanced BioAdjuvants, LLC Adjuvans- und impfstoffzusammensetzungen
WO2018193337A2 (en) * 2017-04-18 2018-10-25 Actorius Innovations And Research Pvt. Ltd Polymer based formulation for release of drugs and bioactives at specific git sites

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323624D0 (en) * 1983-09-02 1983-10-05 Reckitt & Colmann Prod Ltd Medicinal compositions
EP0159604B1 (de) * 1984-04-09 1990-11-07 Toyo Boseki Kabushiki Kaisha Präparat mit verzögerter Freigabe zum Aufbringen auf die Schleimhäute der Mundhöhle
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4933185A (en) * 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
CA1321048C (en) * 1987-03-05 1993-08-10 Robert W. J. Lencki Microspheres and method of producing same
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5260066A (en) * 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent

Also Published As

Publication number Publication date
DE69402153T2 (de) 1997-10-09
JPH07258115A (ja) 1995-10-09
DE69402153D1 (de) 1997-04-24
CA2133271A1 (en) 1995-04-16
EP0652015A2 (de) 1995-05-10
EP0652015B1 (de) 1997-03-19
EP0652015A3 (de) 1995-08-02
US5451411A (en) 1995-09-19
DK0652015T3 (da) 1997-04-14
ES2100632T3 (es) 1997-06-16
GR3023307T3 (en) 1997-08-29

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