DK0652015T3 - Fremgangsmåder og præparater til oral afgivelse af terapeutiske midler - Google Patents

Fremgangsmåder og præparater til oral afgivelse af terapeutiske midler

Info

Publication number
DK0652015T3
DK0652015T3 DK94307259.5T DK94307259T DK0652015T3 DK 0652015 T3 DK0652015 T3 DK 0652015T3 DK 94307259 T DK94307259 T DK 94307259T DK 0652015 T3 DK0652015 T3 DK 0652015T3
Authority
DK
Denmark
Prior art keywords
alginate
agents
therapeutic agents
interaction
oral delivery
Prior art date
Application number
DK94307259.5T
Other languages
English (en)
Inventor
W R Gombotz
R J Mumper
L S Bouchard
A S Hoffman
Original Assignee
Bristol Myers Squibb Co
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Univ Washington filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0652015T3 publication Critical patent/DK0652015T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
DK94307259.5T 1993-10-15 1994-10-04 Fremgangsmåder og præparater til oral afgivelse af terapeutiske midler DK0652015T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/138,367 US5451411A (en) 1993-10-15 1993-10-15 Methods and compositions for the oral delivery of therapeutic agents

Publications (1)

Publication Number Publication Date
DK0652015T3 true DK0652015T3 (da) 1997-04-14

Family

ID=22481704

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94307259.5T DK0652015T3 (da) 1993-10-15 1994-10-04 Fremgangsmåder og præparater til oral afgivelse af terapeutiske midler

Country Status (9)

Country Link
US (1) US5451411A (da)
EP (1) EP0652015B1 (da)
JP (1) JPH07258115A (da)
AT (1) ATE150320T1 (da)
CA (1) CA2133271A1 (da)
DE (1) DE69402153T2 (da)
DK (1) DK0652015T3 (da)
ES (1) ES2100632T3 (da)
GR (1) GR3023307T3 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619660D0 (en) * 1996-09-20 1996-11-06 Scient Hospital Suppl Int Ltd Prevention of gastrointestinal damage
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
DE69941447D1 (de) * 1998-01-05 2009-11-05 Univ Washington Erhöhter transport unter benutzung membranzerstörender stoffe
GB9806530D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
WO2000021572A2 (en) * 1998-10-09 2000-04-20 The University Of Michigan Hydrogels and water soluble polymeric carriers for drug delivery
JP2002539172A (ja) 1999-03-17 2002-11-19 ノバルティス アクチエンゲゼルシャフト Ｔｇｆ−ベータを含む医薬組成物
WO2001024812A1 (en) * 1999-10-06 2001-04-12 N.V. Nutricia USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA
US7737108B1 (en) 2000-01-07 2010-06-15 University Of Washington Enhanced transport using membrane disruptive agents
US6596310B1 (en) 2000-08-23 2003-07-22 Board Of Trustees Operating Michigan State University Method of artificial insemination by timed release of sperm from capsules or solid beads
US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
US20030206957A1 (en) * 2002-05-06 2003-11-06 Scherr George H. Orally administered medicament delivery systems
CA2515213A1 (en) * 2003-02-11 2004-08-26 University Of Washington Stimuli-responsive polymer conjugates and related methods
JP4822092B2 (ja) * 2003-09-01 2011-11-24 大正製薬株式会社 Ｗ／ｏ／ｗ型複合エマルション
DE10350248A1 (de) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
US7744895B2 (en) 2005-08-31 2010-06-29 Yamanashi University Methods of treating allergies using TGF-β1 and allergens
US7718193B2 (en) * 2006-03-16 2010-05-18 University Of Washington Temperature- and pH-responsive polymer compositions
JP5249933B2 (ja) 2006-07-04 2013-07-31 スパームヴァイタル アクティーゼルスカブ 精子の保存及び制御された送達／解放
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
US20080292663A1 (en) * 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
DE102007059939A1 (de) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen
IT1392471B1 (it) * 2008-11-25 2012-03-09 Pharmafilm S R L Collutorio in forma di sospensione stabile comprendente microsfere che incorporano un principio attivo.
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
EP2575891A4 (en) * 2010-06-03 2014-10-08 Rph Pharmaceuticals Ab FORMULATIONS PRESERVING BIOACTIVITY AND METHODS FOR THEIR PREPARATION
US9165703B2 (en) * 2010-08-25 2015-10-20 Brown University Methods and systems for prolonged localization of drug delivery
US20120213856A1 (en) * 2011-02-23 2012-08-23 Po-Lun Wang Manufacturing Method of Microcapsule
EP4218808A3 (en) 2012-03-12 2023-08-09 Advanced BioAdjuvants, LLC Adjuvant and vaccine compositions
US11596607B2 (en) * 2017-04-18 2023-03-07 Actorious Innovations And Research Pvt. Ltd. Polymer based formulation for release of drugs and bioactives at specific GIT sites

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323624D0 (en) * 1983-09-02 1983-10-05 Reckitt & Colmann Prod Ltd Medicinal compositions
US4740365A (en) * 1984-04-09 1988-04-26 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4933185A (en) * 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
CA1321048C (en) * 1987-03-05 1993-08-10 Robert W. J. Lencki Microspheres and method of producing same
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5260066A (en) * 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent

Also Published As

Publication number Publication date
DE69402153T2 (de) 1997-10-09
EP0652015A3 (en) 1995-08-02
GR3023307T3 (en) 1997-08-29
CA2133271A1 (en) 1995-04-16
JPH07258115A (ja) 1995-10-09
EP0652015B1 (en) 1997-03-19
US5451411A (en) 1995-09-19
ATE150320T1 (de) 1997-04-15
DE69402153D1 (de) 1997-04-24
ES2100632T3 (es) 1997-06-16
EP0652015A2 (en) 1995-05-10

Similar Documents

Publication Publication Date Title
DK0652015T3 (da) Fremgangsmåder og præparater til oral afgivelse af terapeutiske midler
ATE282425T1 (de) Verfahren zur behandlung von endothelialen verletzungen
GB9316895D0 (en) Hepatoselective insulin analogues
ATE467425T1 (de) Gezielte zufuhr von pharmazeutischen agenzien zu verletzten geweben
WO1996025947A3 (en) Induction of e-selectin for targetting therapeutic agents
DK0721501T3 (da) Farmaceutisk præparat der omfatter phosphatase eller et derivat deraf
DK0490077T3 (da) Antisense-oligonukleotider til behandling af cancer
DK0851925T3 (da) Humane Væksthormonvarianter
PT1039802E (pt) Dispositivo terapeutico transdermico contendo capsaicina e analogos da capsaicina.
EP1138673A3 (en) Novel carbamates and ureas as modifiers of multi-drug resistance
DE602004025726D1 (de) Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
WO2000021548A3 (en) Angiogenically effective unit dose of fgf and method of administering
BR9708114A (pt) Análogos xantona para o tratamento de doenças infecciosas.
EP0934748A3 (en) Von Willenbrand factor (vWF)- containing preparation, process for preparing vWF-containing preparations, and use of such preparations
GR3036774T3 (en) Compositions containing G-CSF and TNF binding protein.
ATE127020T1 (de) Pharmazeutische zusammensetzungen mit eierschalenbestandteilen und ihre herstellung und verwendung.
IL107153A (en) Pharmaceutical compositions for preventing insulin-dependent diabetes mellitus comprising IL10 and method for their manufacture
DE60334711D1 (de) Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren
PT817646E (pt) Metodos de tratamento da inflamacao e formulacoes para esse fim
NO995944D0 (no) Anti-arrytmisk blanding og fremgangsmåter for behandling
JPS5738716A (en) Incised wound treating composition
WO1991003226A3 (en) Pharmaceutical compositions containing aromatic polymers and therapeutic methods using the same
IL111805A0 (en) Pharmaceutical compositions comprising dimeticone for the treatment of aphthae
GR3020411T3 (en) Novel ascorbic acid derivatives
IT1280010B1 (it) Composizione farmaceutica a base di un complesso agente terapeutico/ matrice polimerica dotato di migliorate caratteristiche disapore