ATE151756T1 - Pyrimidinderivate, ihre verfahren zur herstellung, die erlangten zwischenprodukte, ihre anwendung als heilmittel und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Pyrimidinderivate, ihre verfahren zur herstellung, die erlangten zwischenprodukte, ihre anwendung als heilmittel und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE151756T1 ATE151756T1 AT92401363T AT92401363T ATE151756T1 AT E151756 T1 ATE151756 T1 AT E151756T1 AT 92401363 T AT92401363 T AT 92401363T AT 92401363 T AT92401363 T AT 92401363T AT E151756 T1 ATE151756 T1 AT E151756T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- alkyl
- alkenyl
- alkoxy
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9106203A FR2676734B1 (fr) | 1991-05-23 | 1991-05-23 | Nouveaux derives de la pyrimidine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE151756T1 true ATE151756T1 (de) | 1997-05-15 |
Family
ID=9413040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92401363T ATE151756T1 (de) | 1991-05-23 | 1992-05-20 | Pyrimidinderivate, ihre verfahren zur herstellung, die erlangten zwischenprodukte, ihre anwendung als heilmittel und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5474996A (de) |
| EP (1) | EP0515265B1 (de) |
| JP (1) | JP3182213B2 (de) |
| AT (1) | ATE151756T1 (de) |
| CA (1) | CA2069261A1 (de) |
| DE (1) | DE69219008T2 (de) |
| DK (1) | DK0515265T3 (de) |
| ES (1) | ES2100314T3 (de) |
| FR (1) | FR2676734B1 (de) |
| GR (1) | GR3023295T3 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU94026277A (ru) * | 1993-07-12 | 1996-05-27 | Сандоз АГ (CH) | Пиримидиниловые производные акриловой кислоты, способ их получения, способ подавления фитопатогенных грибов, фунгицидное средство |
| GB9519787D0 (en) * | 1995-09-28 | 1995-11-29 | Sandoz Ltd | Organic compounds |
| USD393531S (en) | 1996-03-27 | 1998-04-14 | Mag-Nif Incorporated | Coin bank |
| KR100239800B1 (ko) * | 1996-11-28 | 2000-03-02 | 손경식 | 4,5-디아미노 피리미딘 유도체 및 이의 제조방법 |
| FR2781219B1 (fr) * | 1998-07-16 | 2000-08-25 | Synthelabo | Procede pour la preparation de 5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4 (1h, 3h) -dione |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| EP2404603A1 (de) | 2000-10-23 | 2012-01-11 | Glaxosmithkline LLC | Neue trisubstitutierte 8H-Pyrido[2,3-d]pyrimidin-7-Onderivate zur Behandlung von durch CSBP/p38kinase vermittelten Krankheiten |
| WO2003084936A2 (en) * | 2002-04-10 | 2003-10-16 | Orchid Chemicals & Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| PE20061351A1 (es) | 2005-03-25 | 2007-01-14 | Glaxo Group Ltd | COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38 |
| EP1896476A2 (de) * | 2005-06-28 | 2008-03-12 | Orchid Research Laboratories Limited | Neue pyrazolopyrimidinonderivate |
| EP2479173A1 (de) * | 2007-04-27 | 2012-07-25 | Purdue Pharma LP | Zur Behandlung von Schmerzen geeignete therapeutische Mittel |
| MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2810951B1 (de) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) * | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| US8536087B2 (en) | 2010-04-08 | 2013-09-17 | International Imaging Materials, Inc. | Thermographic imaging element |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| BR112013011737A2 (pt) | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3609596A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| US4935516A (en) * | 1988-01-29 | 1990-06-19 | Ube Industries, Ltd. | Process for preparing 4-hydroxypyrimidine |
| DK160270C (da) * | 1988-12-16 | 1991-08-05 | Cheminova Agro As | Fremgangsmaade til fremstilling af 2,4- eller 2,4,5-substituerede 6-hydroxypyrimidiner |
| EP0407342A3 (en) * | 1989-07-06 | 1991-07-10 | Ciba-Geigy Ag | Pyrimidine derivatives |
| GB8917222D0 (en) * | 1989-07-27 | 1989-09-13 | Schering Agrochemicals Ltd | Herbicides |
| US5100897A (en) * | 1989-08-28 | 1992-03-31 | Merck & Co., Inc. | Substituted pyrimidinones as angiotensin ii antagonists |
| EP0435827A3 (en) * | 1989-12-28 | 1991-11-13 | Ciba-Geigy Ag | Diaza compounds |
| CA2053148A1 (en) * | 1990-10-16 | 1992-04-17 | Karnail Atwal | Dihydropyrimidine derivatives |
| DE4039630A1 (de) * | 1990-12-12 | 1992-06-17 | Bayer Ag | Substituierte pyrimidylamidoxime |
-
1991
- 1991-05-23 FR FR9106203A patent/FR2676734B1/fr not_active Expired - Fee Related
-
1992
- 1992-05-20 DK DK92401363.4T patent/DK0515265T3/da active
- 1992-05-20 DE DE69219008T patent/DE69219008T2/de not_active Expired - Fee Related
- 1992-05-20 EP EP92401363A patent/EP0515265B1/de not_active Expired - Lifetime
- 1992-05-20 AT AT92401363T patent/ATE151756T1/de not_active IP Right Cessation
- 1992-05-20 ES ES92401363T patent/ES2100314T3/es not_active Expired - Lifetime
- 1992-05-22 US US07/888,750 patent/US5474996A/en not_active Expired - Lifetime
- 1992-05-22 CA CA002069261A patent/CA2069261A1/fr not_active Abandoned
- 1992-05-22 JP JP15426092A patent/JP3182213B2/ja not_active Expired - Fee Related
-
1997
- 1997-04-30 GR GR960403065T patent/GR3023295T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0515265A1 (de) | 1992-11-25 |
| GR3023295T3 (en) | 1997-07-30 |
| JPH05178840A (ja) | 1993-07-20 |
| EP0515265B1 (de) | 1997-04-16 |
| US5474996A (en) | 1995-12-12 |
| ES2100314T3 (es) | 1997-06-16 |
| DE69219008D1 (de) | 1997-05-22 |
| FR2676734B1 (fr) | 1995-05-19 |
| CA2069261A1 (fr) | 1992-11-24 |
| FR2676734A1 (fr) | 1992-11-27 |
| DE69219008T2 (de) | 1997-11-06 |
| DK0515265T3 (da) | 1997-10-20 |
| JP3182213B2 (ja) | 2001-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |