ATE151763T1 - Taxolderivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen. - Google Patents

Taxolderivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.

Info

Publication number
ATE151763T1
ATE151763T1 AT94908385T AT94908385T ATE151763T1 AT E151763 T1 ATE151763 T1 AT E151763T1 AT 94908385 T AT94908385 T AT 94908385T AT 94908385 T AT94908385 T AT 94908385T AT E151763 T1 ATE151763 T1 AT E151763T1
Authority
AT
Austria
Prior art keywords
radical
pharmaceutical compositions
general formula
production
compositions containing
Prior art date
Application number
AT94908385T
Other languages
English (en)
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Jean-Pierre Pulicani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE151763T1 publication Critical patent/ATE151763T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94908385T 1993-03-02 1994-02-28 Taxolderivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen. ATE151763T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9302370A FR2702212B1 (fr) 1993-03-02 1993-03-02 Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE151763T1 true ATE151763T1 (de) 1997-05-15

Family

ID=9444565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94908385T ATE151763T1 (de) 1993-03-02 1994-02-28 Taxolderivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.

Country Status (19)

Country Link
US (2) US5556877A (de)
EP (1) EP0687259B1 (de)
JP (1) JP3782443B2 (de)
KR (1) KR960701034A (de)
AT (1) ATE151763T1 (de)
AU (1) AU683449B2 (de)
CZ (1) CZ223795A3 (de)
DE (1) DE69402694T2 (de)
DK (1) DK0687259T3 (de)
ES (1) ES2101513T3 (de)
FI (1) FI954111A0 (de)
FR (1) FR2702212B1 (de)
GR (1) GR3023162T3 (de)
NO (1) NO953452D0 (de)
NZ (1) NZ262137A (de)
PL (1) PL310441A1 (de)
SK (1) SK107295A3 (de)
WO (1) WO1994020484A1 (de)
ZA (1) ZA941387B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
WO1997045105A1 (en) 1996-05-24 1997-12-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
FR2750989B1 (fr) * 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
KR100225535B1 (ko) 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US20030157187A1 (en) * 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE256117T1 (de) 1999-05-17 2003-12-15 Bristol Myers Squibb Co Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
AU776767B2 (en) 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C10 heterosubstituted acetate taxanes as antitumor agents
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
EP2276755A4 (de) 2008-03-31 2011-05-04 Univ Florida State Res Found C(10)-ethylester- und c(10)-cyclopropylester-substituierte taxane
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
US10550093B2 (en) 2015-07-01 2020-02-04 The Research Foundation For The State University Of New York Third generation taxoids and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
WO1993021173A1 (en) * 1992-04-17 1993-10-28 Abbott Laboratories Taxol derivatives
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JP3782443B2 (ja) 2006-06-07
WO1994020484A1 (fr) 1994-09-15
US5556877A (en) 1996-09-17
US5654449A (en) 1997-08-05
JPH08509959A (ja) 1996-10-22
ES2101513T3 (es) 1997-07-01
FR2702212B1 (fr) 1995-04-07
FI954111A7 (fi) 1995-09-01
SK107295A3 (en) 1996-06-05
DK0687259T3 (da) 1997-05-26
ZA941387B (en) 1994-09-29
GR3023162T3 (en) 1997-07-30
DE69402694T2 (de) 1997-10-16
DE69402694D1 (de) 1997-05-22
NO953452L (no) 1995-09-01
PL310441A1 (en) 1995-12-11
AU683449B2 (en) 1997-11-13
AU6144694A (en) 1994-09-26
KR960701034A (ko) 1996-02-24
FR2702212A1 (fr) 1994-09-09
FI954111L (fi) 1995-09-01
FI954111A0 (fi) 1995-09-01
EP0687259B1 (de) 1997-04-16
EP0687259A1 (de) 1995-12-20
NO953452D0 (no) 1995-09-01
NZ262137A (en) 1997-11-24
CZ223795A3 (en) 1995-12-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name