ATE152127T1 - Muteine des menschlichen parathormons und ihre herstellung - Google Patents

Muteine des menschlichen parathormons und ihre herstellung

Info

Publication number: ATE152127T1
Authority: AT; Austria
Prior art keywords: amino acid; recombinant dna; human parathyroid; residue; parathyroid hormone
Prior art date: 1991-08-07

Application number

AT92113322T

Other languages

English (en)

Inventor

Tsunehiko Fukuda

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-07

Filing date

1992-08-05

Publication date

1997-05-15

1992-06-26 Priority claimed from JP4169713A external-priority patent/JPH05271279A/ja

1992-08-05 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE152127T1 publication Critical patent/ATE152127T1/de

Links

239000000199 parathyroid hormone Substances 0.000 title abstract 2
102000003982 Parathyroid hormone Human genes 0.000 title 1
108090000445 Parathyroid hormone Proteins 0.000 title 1
108020004511 Recombinant DNA Proteins 0.000 abstract 4
125000000539 amino acid group Chemical group 0.000 abstract 4
101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 abstract 3
101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 abstract 3
125000003275 alpha amino acid group Chemical group 0.000 abstract 3
102000058004 human PTH Human genes 0.000 abstract 3
238000006467 substitution reaction Methods 0.000 abstract 2
241000588724 Escherichia coli Species 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT92113322T 1991-08-07 1992-08-05 Muteine des menschlichen parathormons und ihre herstellung ATE152127T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP19805691		1991-08-07
JP4169713A JPH05271279A (ja)	1991-08-07	1992-06-26	ヒト副甲状腺ホルモンムテインおよびその製造法

Publications (1)

Publication Number	Publication Date
ATE152127T1 true ATE152127T1 (de)	1997-05-15

Family

ID=26492969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92113322T ATE152127T1 (de)	1991-08-07	1992-08-05	Muteine des menschlichen parathormons und ihre herstellung

Country Status (4)

Country	Link
EP (1)	EP0528271B1 (de)
AT (1)	ATE152127T1 (de)
CA (1)	CA2075408A1 (de)
DE (1)	DE69219242T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4415796A (en) *	1994-12-07	1996-06-26	Bionebraska, Inc.	Production of c-terminal amidated peptides from recombinant protein constructs
CA2178894A1 (en) *	1995-06-15	1996-12-16	Tsunehiko Fukuda	Parathyroid hormone derivatives and their use
AU3161997A (en) *	1996-06-21	1998-01-14	Francis Gossard	A novel hypertension related calcium regulated gene (hcarg)
US9585934B2 (en) *	2014-10-22	2017-03-07	Extend Biosciences, Inc.	Therapeutic vitamin D conjugates
WO2016065052A1 (en)	2014-10-22	2016-04-28	Extend Biosciences, Inc.	Insulin vitamin d conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3312928A1 (de) *	1983-04-11	1984-11-22	Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig	Human-parathormon produzierende hybridvektoren und human-parathormongen
EP0604706A1 (de) *	1986-10-22	1994-07-06	GAUTVIK, Kaare M., Dr.	Herstellung von humanem Parathormon mittels Mikroorganismen
EP0341963A3 (de) *	1988-05-09	1991-07-24	Merck & Co. Inc.	Parathyroidhormonhemmer
US5171670A (en) *	1989-05-12	1992-12-15	The General Hospital Corporation	Recombinant dna method for production of parathyroid hormone
CA2040264A1 (en) *	1990-04-12	1991-10-13	Tatsuhiko Kanmera	Parathyroid hormone antagonists

1992
- 1992-08-05 AT AT92113322T patent/ATE152127T1/de not_active IP Right Cessation
- 1992-08-05 EP EP92113322A patent/EP0528271B1/de not_active Expired - Lifetime
- 1992-08-05 DE DE69219242T patent/DE69219242T2/de not_active Expired - Fee Related
- 1992-08-06 CA CA002075408A patent/CA2075408A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0528271B1 (de)	1997-04-23
EP0528271A1 (de)	1993-02-24
DE69219242T2 (de)	1997-09-25
DE69219242D1 (de)	1997-05-28
CA2075408A1 (en)	1993-02-08

Similar Documents

Publication	Publication Date	Title
ATE123949T1 (de)	1995-07-15	B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
EP0355460A3 (de)	1991-04-03	Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
AU704515C (en)	2002-03-28	Novel protein and process for producing the same
EP0346429A4 (en)	1990-10-10	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
EP0235205A4 (de)	1989-08-09	Peptidanalogedes insulinähnlichen wachstumsfaktors-1 bei säugetieren.
EP0607297A4 (en)	1995-10-25	Hormone analogs with multiple ctp extensions.
SG52690A1 (en)	1998-09-28	Process for the production of biologically active protein (e.g. tgf)
ATE85810T1 (de)	1993-03-15	Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.
IL95057A0 (en)	1991-06-10	Recombinant gene coding for a protein such as urate oxidase
GB8727045D0 (en)	1987-12-23	Immunoglobulin e competitor
GR3031927T3 (en)	2000-03-31	Cysteine depleted il-6 muteins
ATE140008T1 (de)	1996-07-15	Polypeptid
ATE121754T1 (de)	1995-05-15	Vakzine gegen bordetella.
GB8821795D0 (en)	1988-10-19	New derivatives of human/bovine basic fibroplast growth factor
DE69219242D1 (de)	1997-05-28	Muteine des menschlichen Parathormons und ihre Herstellung
AU9026691A (en)	1992-06-11	New human recombinant gamma interferon
HUT62327A (en)	1993-04-28	Process for producing somatotropins modified in their alfa-helix 1 region and their combination with other mutants
IL93851A0 (en)	1990-12-23	Process for the expression of recombinant gene
ATE131175T1 (de)	1995-12-15	Protein mit fibroblasten-wachstumsfaktor- rezeptoraktivität.
BR1100940A (pt)	2000-08-01	Polipeptìdeos puros, sequências adn, molécula adn recombinada, célula hospedeira, processo de manipulação genética para produção de polipeptìdeo, e, uso de um polipeptìdeo
CA2087450A1 (en)	1992-01-17	Stable and bioactive modified somatotropins
DE69306273D1 (de)	1997-01-16	Mitogen für die glatte Muskulatur und dessen kodierende DNS
ATE141093T1 (de)	1996-08-15	Polypeptid
EP1295943A4 (de)	2005-11-16	Polypeptide mit aktivität der stimulierung von neutrophilen
JPS6474988A (en)	1989-03-20	Synthetic gene of cystatin c, corresponding recombinant plasmid and recombinant

Legal Events

Date	Code	Title	Description
1997-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties