ATE152724T1 - Synthetische verwandlung von bryostatin 2 in bryostatin 1 - Google Patents

Synthetische verwandlung von bryostatin 2 in bryostatin 1

Info

Publication number: ATE152724T1
Authority: AT; Austria
Prior art keywords: bryostatin; synthetic conversion; synthetic; conversion; converted
Prior art date: 1990-12-31

Application number

AT91311568T

Other languages

German (de)

English (en)

Inventor

George R Pettit

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-31

Filing date

1991-12-12

Publication date

1997-05-15

1991-12-12 Application filed by Univ Arizona filed Critical Univ Arizona

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE152724T1 publication Critical patent/ATE152724T1/de

Links

MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 title abstract 2
229960005539 bryostatin 1 Drugs 0.000 title abstract 2
LIPGUSBNMQRYNL-IZBIBDMISA-N bryostatin 2 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 LIPGUSBNMQRYNL-IZBIBDMISA-N 0.000 title abstract 2
238000006243 chemical reaction Methods 0.000 title 1
238000010511 deprotection reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Auxiliary Devices For Music (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
External Artificial Organs (AREA)
Medicines Containing Plant Substances (AREA)

AT91311568T 1990-12-31 1991-12-12 Synthetische verwandlung von bryostatin 2 in bryostatin 1 ATE152724T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/636,212 US5072004A (en)	1990-12-31	1990-12-31	Synthetic conversion of bryostatin 2 into bryostatin 1

Publications (1)

Publication Number	Publication Date
ATE152724T1 true ATE152724T1 (de)	1997-05-15

Family

ID=24550938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91311568T ATE152724T1 (de)	1990-12-31	1991-12-12	Synthetische verwandlung von bryostatin 2 in bryostatin 1

Country Status (10)

Country	Link
US (1)	US5072004A (fr)
EP (1)	EP0496160B1 (fr)
JP (1)	JP3225318B2 (fr)
AT (1)	ATE152724T1 (fr)
CA (1)	CA2057441C (fr)
DE (1)	DE69126011T2 (fr)
DK (1)	DK0496160T3 (fr)
ES (1)	ES2103788T3 (fr)
GR (1)	GR3023990T3 (fr)
MX (1)	MX9102830A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7256286B2 (en) *	1999-11-30	2007-08-14	The Board Of Trustees Of The Leland Stanford Junior University	Bryostatin analogues, synthetic methods and uses
ES2314056T3 (es) *	2001-05-02	2009-03-16	Blanchette Rockefeller Neurosciences Institute	Activadores de la anhidrasa carbonica para mejorar el aprendizaje y la memoria.
US20050065205A1 (en) *	2002-03-07	2005-03-24	Daniel Alkon	Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en)	2002-03-07	2004-11-30	Blanchette Rockefeller Neurosciences Institute	Methods for Alzheimer's Disease treatment and cognitive enhancement
US20080004332A1 (en) *	2002-03-07	2008-01-03	Alkon Daniel L	Methods for alzheimer's disease treatment and cognitive enhancement
TW201206425A (en)	2004-05-18	2012-02-16	Brni Neurosciences Inst	Treatment of depressive disorders
US20070054890A1 (en)	2005-07-29	2007-03-08	Alkon Daniel L	Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
US7754465B2 (en) *	2006-04-27	2010-07-13	James A Papp	Decontamination of biological agents
US20080025961A1 (en)	2006-07-28	2008-01-31	Alkon Daniel L	Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
WO2008100450A2 (fr)	2007-02-09	2008-08-21	Blanchette Rockefeller Neurosciences Institute	Effets thérapeutiques de bryostatines, de bryologues et d'autres substances apparentées sur l'altération de la mémoire induite par une ischémie/un accident vasculaire cérébral et une lésion cérébrale
EP3332797A3 (fr)	2007-02-09	2018-08-01	Blanchette Rockefeller Neurosciences Institute	Effets thérapeutiques des bryostatines, bryologues et autres substances apparentées sur les troubles de la mémoire et les lésions cérébrales suite à un traumatisme crânien
US20120027687A1 (en)	2010-07-08	2012-02-02	Alkon Daniel L	Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke
EP2605773A1 (fr)	2010-08-19	2013-06-26	Blanchette Rockefeller Neurosciences, Institute	Traitement de troubles cognitifs associés à des épines dendritiques mettant en uvre des activateurs de pkc
CA2855932A1 (fr)	2011-11-13	2013-05-16	Blanchette Rockefeller Neurosciences Institute	Activateurs de pkc et des combinaisons de ceux-ci
WO2016130969A1 (fr)	2015-02-13	2016-08-18	George Robert Pettit	Composés silstatine
US20180217163A1 (en)	2015-05-11	2018-08-02	Daniel L. Alkon	Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
WO2019094709A1 (fr)	2017-11-09	2019-05-16	Pettit George R	Composés de bétulastatine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4560774A (en) *	1982-11-17	1985-12-24	Arizona State University	Macrocyclic lactones
US4611066A (en) *	1984-08-10	1986-09-09	Arizona State University	Bryostatins 4 to 8
US4833257A (en) *	1986-07-28	1989-05-23	Arizona Board Of Regents	Compositions of matter and methods of using same

1990
- 1990-12-31 US US07/636,212 patent/US5072004A/en not_active Expired - Lifetime
1991
- 1991-12-11 CA CA002057441A patent/CA2057441C/fr not_active Expired - Fee Related
- 1991-12-12 EP EP91311568A patent/EP0496160B1/fr not_active Expired - Lifetime
- 1991-12-12 AT AT91311568T patent/ATE152724T1/de not_active IP Right Cessation
- 1991-12-12 DE DE69126011T patent/DE69126011T2/de not_active Expired - Fee Related
- 1991-12-12 ES ES91311568T patent/ES2103788T3/es not_active Expired - Lifetime
- 1991-12-12 DK DK91311568.9T patent/DK0496160T3/da active
- 1991-12-27 JP JP36135791A patent/JP3225318B2/ja not_active Expired - Fee Related
- 1991-12-27 MX MX9102830A patent/MX9102830A/es not_active IP Right Cessation
1997
- 1997-07-02 GR GR970401645T patent/GR3023990T3/el unknown

Also Published As

Publication number	Publication date
ES2103788T3 (es)	1997-10-01
GR3023990T3 (en)	1997-10-31
EP0496160A1 (fr)	1992-07-29
US5072004A (en)	1991-12-10
DE69126011T2 (de)	1997-09-25
DK0496160T3 (da)	1997-07-28
JPH0867683A (ja)	1996-03-12
JP3225318B2 (ja)	2001-11-05
MX9102830A (es)	1992-06-01
DE69126011D1 (de)	1997-06-12
CA2057441C (fr)	2002-06-11
EP0496160B1 (fr)	1997-05-07
CA2057441A1 (fr)	1992-07-01

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Legal Events

Date	Code	Title	Description
1997-12-15	UEP	Publication of translation of european patent specification
2005-09-15	REN	Ceased due to non-payment of the annual fee