ATE15387T1 - Verfahren zum bestimmen von enzym-inhibitorkomplexen. - Google Patents
Verfahren zum bestimmen von enzym-inhibitorkomplexen.Info
- Publication number
- ATE15387T1 ATE15387T1 AT81107730T AT81107730T ATE15387T1 AT E15387 T1 ATE15387 T1 AT E15387T1 AT 81107730 T AT81107730 T AT 81107730T AT 81107730 T AT81107730 T AT 81107730T AT E15387 T1 ATE15387 T1 AT E15387T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- enzyme inhibitor
- inhibitor
- antibody
- methods
- Prior art date
Links
- 229940125532 enzyme inhibitor Drugs 0.000 title abstract 3
- 239000002532 enzyme inhibitor Substances 0.000 title abstract 3
- 229940088598 enzyme Drugs 0.000 abstract 8
- 102000004190 Enzymes Human genes 0.000 abstract 7
- 108090000790 Enzymes Proteins 0.000 abstract 7
- 239000011159 matrix material Substances 0.000 abstract 3
- 239000013060 biological fluid Substances 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19216680A | 1980-09-30 | 1980-09-30 | |
| EP81107730A EP0048989B1 (de) | 1980-09-30 | 1981-09-29 | Verfahren zum Bestimmen von Enzym-Inhibitor-Komplexen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE15387T1 true ATE15387T1 (de) | 1985-09-15 |
Family
ID=22708529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81107730T ATE15387T1 (de) | 1980-09-30 | 1981-09-29 | Verfahren zum bestimmen von enzym-inhibitorkomplexen. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0048989B1 (de) |
| JP (1) | JPS5794660A (de) |
| AT (1) | ATE15387T1 (de) |
| CA (1) | CA1176560A (de) |
| DE (1) | DE3172143D1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3269008D1 (en) * | 1981-11-02 | 1986-03-20 | James Walter Ryan | Method for assaying proteases with tagged proteinaceous inhibitors |
| US4499186A (en) * | 1982-12-30 | 1985-02-12 | University Of Illinois, Board Of Trustees | Diagnosing autoimmune rheumatoid arthritis by measuring proteolytic activity of α2 -macroglobulin |
| JPS6134465A (ja) * | 1984-07-26 | 1986-02-18 | Teijin Ltd | ヒトα↓２−プラスミンインヒビタ−に対するモノクロ−ナル抗体を用いた免疫学的測定試薬及びキツト |
| DE3531778A1 (de) * | 1985-09-06 | 1987-03-12 | Behringwerke Ag | Verfahren zur bestimmung von proteaseinhibitoren |
| JPS6488368A (en) * | 1987-09-30 | 1989-04-03 | Shigeru Hayashi | Method for measuring complex of urokinase and urokinase inhibitor |
| GB9119102D0 (en) * | 1991-09-07 | 1991-10-23 | Biosyn Ltd | Bioimmunassay |
| GB9312638D0 (en) * | 1993-06-18 | 1993-08-04 | Hafslund Nycomed As | Assay |
| NL9301134A (nl) * | 1993-06-29 | 1995-01-16 | Inst Voor Agrotech Onderzoek | Werkwijze voor het detekteren en eventueel kwantificeren van aktiviteit van ten minste één protease-inhibitor in een te analyseren mengsel, alsmede toepassing van de werkwijze voor het bepalen van de (rest)aktiviteit van één (of meer) afzonderlijke (iso)type(s) protease-inhibitor(en) en toepassing van de werkwijze voor het bepalen van de totale (rest)aktiviteit van een mengsel eventueel na een verwerkingsproces zoals een proces ter verwijdering of inaktivatie van protease-inhibitor(en). |
| FI100557B (fi) * | 1994-08-26 | 1997-12-31 | Ulf-Haakan Stenman | Vapaan trypsinogeeni-2:n määritys |
| EP0759556A3 (de) * | 1995-07-24 | 1998-05-20 | BEHRINGWERKE Aktiengesellschaft | Verfahren zur Quantifizierung aktivierter Faktoren |
| CA2536150A1 (en) * | 2003-08-19 | 2005-02-24 | Novozymes A/S | Active-site titration of glycosyl hydrolases |
| US10690670B2 (en) * | 2013-01-20 | 2020-06-23 | Dyax Corp. | Assays for determining levels of plasma protease C1 inhibitor |
| WO2020214638A1 (en) | 2019-04-16 | 2020-10-22 | Dyax Corp. | Methods for quantitation of functional c1 esterase inhibitor (fc1-inh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7602422A (nl) * | 1976-03-08 | 1977-09-12 | Leuven Res & Dev Vzw | Trombosetest. |
| DE2836046A1 (de) * | 1978-08-17 | 1980-02-28 | Behringwerke Ag | Immunologisches bestimmungsverfahren |
| JPS5646465A (en) * | 1979-09-25 | 1981-04-27 | Seikagaku Kogyo Co Ltd | Measuring method for man pancreas secretory inhibiter in humor |
| JPS56118671A (en) * | 1980-02-22 | 1981-09-17 | Amano Pharmaceut Co Ltd | Measuring method of specific enzyme immunity of hybrid type protein |
| DE3016575A1 (de) * | 1980-04-30 | 1981-11-05 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur immunologischen bestimmung von enzymen, mittel zur durchfuehrung des verfahrens und seine verwandung |
-
1981
- 1981-09-29 CA CA000386866A patent/CA1176560A/en not_active Expired
- 1981-09-29 EP EP81107730A patent/EP0048989B1/de not_active Expired
- 1981-09-29 AT AT81107730T patent/ATE15387T1/de not_active IP Right Cessation
- 1981-09-29 DE DE8181107730T patent/DE3172143D1/de not_active Expired
- 1981-09-30 JP JP56154047A patent/JPS5794660A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0048989B1 (de) | 1985-09-04 |
| EP0048989A2 (de) | 1982-04-07 |
| EP0048989A3 (en) | 1982-05-12 |
| CA1176560A (en) | 1984-10-23 |
| JPS5794660A (en) | 1982-06-12 |
| JPH041304B2 (de) | 1992-01-10 |
| DE3172143D1 (en) | 1985-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |