ATE154028T1 - Verfahren zur herstellung von azithromycin dihydrochloriden - Google Patents

Verfahren zur herstellung von azithromycin dihydrochloriden

Info

Publication number: ATE154028T1
Authority: AT; Austria
Prior art keywords: dihydrochlorides; azithromycin; producing; producing azithromycin; broad
Prior art date: 1994-04-15

Application number

AT95105285T

Other languages

English (en)

Inventor

Nevenka Lopotar

Stjepen Mutak

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-15

Filing date

1995-04-07

Publication date

1997-06-15

1995-04-07 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE154028T1 publication Critical patent/ATE154028T1/de

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
WUTMHODASJRZBL-KUJJYQHYSA-N Cl.Cl.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 Chemical compound Cl.Cl.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WUTMHODASJRZBL-KUJJYQHYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95105285T 1994-04-15 1995-04-07 Verfahren zur herstellung von azithromycin dihydrochloriden ATE154028T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR940251A HRP940251B1 (en)	1994-04-15	1994-04-15	Process for the preparation of azithromycin dihydrochloride

Publications (1)

Publication Number	Publication Date
ATE154028T1 true ATE154028T1 (de)	1997-06-15

Family

ID=10946105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95105285T ATE154028T1 (de)	1994-04-15	1995-04-07	Verfahren zur herstellung von azithromycin dihydrochloriden

Country Status (16)

Country	Link
EP (1)	EP0677530B1 (de)
JP (1)	JP3075681B2 (de)
CN (1)	CN1042033C (de)
AT (1)	ATE154028T1 (de)
BG (1)	BG61769B1 (de)
CA (1)	CA2146475C (de)
DE (1)	DE69500327T2 (de)
ES (1)	ES2104441T3 (de)
HR (1)	HRP940251B1 (de)
HU (1)	HU217553B (de)
PL (1)	PL177292B1 (de)
RO (1)	RO113737B1 (de)
RU (1)	RU2134271C1 (de)
SI (1)	SI9500124A (de)
SK (1)	SK281178B6 (de)
UA (1)	UA41902C2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
KR100431431B1 (ko) *	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
EP1648473B1 (de)	2003-07-24	2009-01-28	PLIVA HRVATSKA d.o.o.	Schnellösliches azithromycin in einzeldosisform
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
CN100343267C (zh) *	2005-08-05	2007-10-17	新昌国邦化学工业有限公司	阿奇霉素酒石酸盐的制备方法
CN100427499C (zh) *	2005-12-20	2008-10-22	山东诚创医药技术开发有限公司	一种阿奇霉素的可溶性盐及其制备方法
CN101092440B (zh) *	2007-07-19	2010-05-26	浙江尖峰药业有限公司	硫酸阿奇霉素的制备方法
CN102746350A (zh) *	2011-04-21	2012-10-24	常州泰康制药有限公司	盐酸阿奇霉素的制备方法
CN104045674B (zh) *	2014-05-21	2017-01-04	丽珠医药集团股份有限公司	一种阿奇霉素的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
SI8311553A8 (en) *	1983-07-18	1995-06-30	Pliva Pharm & Chem Works	Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones
CA2064634C (en) *	1991-04-04	1998-08-04	James V. Heck	9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions

1994
- 1994-04-15 HR HR940251A patent/HRP940251B1/xx not_active IP Right Cessation
1995
- 1995-04-06 CA CA002146475A patent/CA2146475C/en not_active Expired - Fee Related
- 1995-04-07 AT AT95105285T patent/ATE154028T1/de not_active IP Right Cessation
- 1995-04-07 DE DE69500327T patent/DE69500327T2/de not_active Expired - Fee Related
- 1995-04-07 EP EP95105285A patent/EP0677530B1/de not_active Expired - Lifetime
- 1995-04-07 ES ES95105285T patent/ES2104441T3/es not_active Expired - Lifetime
- 1995-04-11 RO RO95-00700A patent/RO113737B1/ro unknown
- 1995-04-11 UA UA95048323A patent/UA41902C2/uk unknown
- 1995-04-12 PL PL95308095A patent/PL177292B1/pl not_active IP Right Cessation
- 1995-04-13 SI SI9500124A patent/SI9500124A/sl not_active IP Right Cessation
- 1995-04-13 SK SK491-95A patent/SK281178B6/sk unknown
- 1995-04-13 CN CN95104228A patent/CN1042033C/zh not_active Expired - Fee Related
- 1995-04-13 JP JP07088166A patent/JP3075681B2/ja not_active Expired - Fee Related
- 1995-04-14 BG BG99580A patent/BG61769B1/bg unknown
- 1995-04-14 RU RU95105596A patent/RU2134271C1/ru not_active IP Right Cessation
- 1995-04-14 HU HU9501084A patent/HU217553B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2146475A1 (en)	1995-10-16
DE69500327T2 (de)	1998-01-08
HRP940251B1 (en)	1998-12-31
HU9501084D0 (en)	1995-06-28
HU217553B (hu)	2000-02-28
BG99580A (bg)	1995-12-29
BG61769B1 (bg)	1998-05-29
EP0677530B1 (de)	1997-06-04
ES2104441T3 (es)	1997-10-01
SK49195A3 (en)	1995-11-08
RU95105596A (ru)	1997-01-10
PL177292B1 (pl)	1999-10-29
SI9500124A (en)	1995-10-31
PL308095A1 (en)	1995-10-16
EP0677530A1 (de)	1995-10-18
CN1112566A (zh)	1995-11-29
HUT71840A (en)	1996-02-28
RO113737B1 (ro)	1998-10-30
JP3075681B2 (ja)	2000-08-14
CA2146475C (en)	1999-06-29
JPH0841058A (ja)	1996-02-13
SK281178B6 (sk)	2000-12-11
RU2134271C1 (ru)	1999-08-10
HRP940251A2 (en)	1997-06-30
CN1042033C (zh)	1999-02-10
UA41902C2 (uk)	2001-10-15
DE69500327D1 (de)	1997-07-10

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Legal Events

Date	Code	Title	Description
1998-01-15	UEP	Publication of translation of european patent specification
2007-01-15	REN	Ceased due to non-payment of the annual fee