ATE154357T1 - Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch - Google Patents

Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch

Info

Publication number: ATE154357T1
Authority: AT; Austria
Prior art keywords: opt; substd; halo; cycloalkyl; roco
Prior art date: 1990-03-01

Application number

AT93105234T

Other languages

English (en)

Inventor

Yasuhiro C O Sankyo C Morisawa

Akio C O Sankyo Company Saito

Toshimitsu C O Sankyo C Toyama

Susumu C O Sankyo Compa Kaneko

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-01

Filing date

1991-03-01

Publication date

1997-06-15

1991-03-01 Application filed by Sankyo Co filed Critical Sankyo Co

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE154357T1 publication Critical patent/ATE154357T1/de

Links

RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title abstract 3
239000003905 agrochemical Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000005843 halogen group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
-1 hydroxyimino Chemical group 0.000 abstract 1
FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT93105234T 1990-03-01 1991-03-01 Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch ATE154357T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP5076090		1990-03-01

Publications (1)

Publication Number	Publication Date
ATE154357T1 true ATE154357T1 (de)	1997-06-15

Family

ID=12867790

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT91301749T ATE133174T1 (de)	1990-03-01	1991-03-01	Milbemycinderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch
AT93105234T ATE154357T1 (de)	1990-03-01	1991-03-01	Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch
AT93105233T ATE166651T1 (de)	1990-03-01	1991-03-01	Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT91301749T ATE133174T1 (de)	1990-03-01	1991-03-01	Milbemycinderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT93105233T ATE166651T1 (de)	1990-03-01	1991-03-01	Milbemycinetherderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch

Country Status (14)

Country	Link
US (2)	US5346918A (de)
EP (3)	EP0552817B1 (de)
JP (1)	JP2622197B2 (de)
KR (1)	KR0168848B1 (de)
AT (3)	ATE133174T1 (de)
AU (1)	AU634864B2 (de)
CA (1)	CA2037414A1 (de)
DE (3)	DE69126534T2 (de)
DK (3)	DK0552817T3 (de)
ES (3)	ES2084767T3 (de)
GR (2)	GR3019205T3 (de)
HK (1)	HK1005731A1 (de)
NZ (1)	NZ237276A (de)
ZA (1)	ZA911533B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW202452B (de) *	1989-12-01	1993-03-21	Ciba Geigy Ag
JPH085894B2 (ja) *	1990-03-01	1996-01-24	三共株式会社	ミルベマイシンエーテル誘導体
RU2086552C1 (ru) *	1991-12-18	1997-08-10	Санкио Компани Лимитед	Производные 13-(замещенного тио)ацетоксимилбемицина, способ их получения, инсектицидная композиция и способ защиты растений
US5461168A (en) *	1992-09-01	1995-10-24	Sankyo Company, Limited	Processes for the production of 13-ether derivatives of milbemycins, and intermediates therefor
US5614470A (en) *	1994-04-01	1997-03-25	Sankyo Company, Limited	13-substituted milbemycin derivatives, their preparation and their use
AU3935495A (en) *	1994-11-24	1996-06-17	Sankyo Company Limited	13-etherified milbemycin derivative with insecticidal activity
GB0229804D0 (en) *	2002-12-20	2003-01-29	Syngenta Participations Ag	Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
EP1849363A1 (de) *	2006-03-09	2007-10-31	Cheminova A/S	Synergistische Kombinationen aus Glutaminsäure- und GABA-aktivierten Chloridkanälen agonistischen Pestiziden und mindestens eins von Vitamin E und Niacin
CN111885914B (zh) *	2017-10-27	2022-05-13	投资健康有限责任公司	使用芴衍生物制造扩增的造血干细胞的组合物和方法
CN111217828B (zh) *	2018-11-26	2022-11-25	浙江海正药业股份有限公司	一种乐平霉素的制备方法及其中间体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950360A (en) *	1972-06-08	1976-04-13	Sankyo Company Limited	Antibiotic substances
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4201861A (en) *	1977-10-03	1980-05-06	Merck & Co., Inc.	Acyl derivatives of C-076 compounds
US4173571A (en) *	1977-12-19	1979-11-06	Merck & Co., Inc.	13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
US4203976A (en) *	1978-08-02	1980-05-20	Merck & Co., Inc.	Sugar derivatives of C-076 compounds
US4200581A (en) *	1978-08-04	1980-04-29	Merck & Co., Inc.	Alkyl derivatives of C-076 compounds
JPS5632481A (en) *	1979-08-23	1981-04-01	Sankyo Co Ltd	Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4315023A (en) *	1979-09-06	1982-02-09	Westwood Pharmaceuticals, Inc.	1-Phenethylimidazole derivatives
US4289760A (en) *	1980-05-02	1981-09-15	Merck & Co., Inc.	23-Keto derivatives of C-076 compounds
JPS57120589A (en) *	1981-01-20	1982-07-27	Sankyo Co Ltd	5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide
JPS57190589A (en) *	1981-05-19	1982-11-24	Brother Ind Ltd	Sound displayable sewing machine
US4457920A (en) *	1981-09-03	1984-07-03	Merck & Co., Inc.	4a-Substituted avermectin compounds
US4423209A (en) *	1982-02-26	1983-12-27	Merck & Co., Inc.	Processes for the interconversion of avermectin compounds
JPS5916894A (ja) *	1982-07-21	1984-01-28	Sankyo Co Ltd	ミルベマイシンｄの５−アシルオキシ誘導体
JPS5920285A (ja) *	1982-07-23	1984-02-01	Sankyo Co Ltd	ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
JPS59108785A (ja) *	1982-11-25	1984-06-23	Sankyo Co Ltd	ミルベマイシン類の５−オキシム誘導体
US4469682A (en) *	1983-01-28	1984-09-04	Merck & Co., Inc.	Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
DE3519834C2 (de) *	1984-06-05	1993-12-16	American Cyanamid Co	Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4547491A (en) *	1984-07-18	1985-10-15	Merck & Co., Inc.	C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
EP0180539A1 (de) *	1984-09-18	1986-05-07	Ciba-Geigy Ag	13-Halo- und 13-Hydroximilbemycine
US4646541A (en) *	1984-11-13	1987-03-03	Columbia Gas System Service Corporation	Absorption refrigeration and heat pump system
US4696922A (en) *	1984-11-26	1987-09-29	Ciba-Geigy Corporation	5-azolylacetoxymilbemycins as ecto- and endoparasites
HUT39739A (en) *	1984-12-04	1986-10-29	Ciba Geigy Ag	Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) *	1984-12-14	1988-05-25	Ciba Geigy Ag	Pesticidal 13b-substituted milbemycin derivatives
IL78621A (en) *	1985-04-30	1991-06-30	American Cyanamid Co	Mylbemycin analogs,their preparation and pesticidal compositions containing them
JPS6289685A (ja) *	1985-05-31	1987-04-24	Sankyo Co Ltd	１３−ハロゲンミルベマイシン誘導体
CH669382A5 (en) *	1986-05-21	1989-03-15	Ciba Geigy Ag	13-0-substd. milbemycin derivs. - with insecticidal, acaricidal, nematocidal and anthelmintic activity, prepd. by etherification of 13-0 unsubstituted cpds
AU613521B2 (en) *	1988-09-02	1991-08-01	Sankyo Company Limited	13-substituted milbemycin derivatives, their preparation and use
US5015630A (en) *	1989-01-19	1991-05-14	Merck & Co., Inc.	5-oxime avermectin derivatives
RU2086552C1 (ru) *	1991-12-18	1997-08-10	Санкио Компани Лимитед	Производные 13-(замещенного тио)ацетоксимилбемицина, способ их получения, инсектицидная композиция и способ защиты растений

1991
- 1991-02-14 JP JP3020858A patent/JP2622197B2/ja not_active Expired - Lifetime
- 1991-02-27 US US07/661,833 patent/US5346918A/en not_active Expired - Fee Related
- 1991-02-28 KR KR1019910003395A patent/KR0168848B1/ko not_active Expired - Fee Related
- 1991-03-01 AT AT91301749T patent/ATE133174T1/de active
- 1991-03-01 CA CA002037414A patent/CA2037414A1/en not_active Abandoned
- 1991-03-01 EP EP93105233A patent/EP0552817B1/de not_active Expired - Lifetime
- 1991-03-01 ES ES91301749T patent/ES2084767T3/es not_active Expired - Lifetime
- 1991-03-01 AU AU72026/91A patent/AU634864B2/en not_active Ceased
- 1991-03-01 AT AT93105234T patent/ATE154357T1/de not_active IP Right Cessation
- 1991-03-01 ES ES93105234T patent/ES2104987T3/es not_active Expired - Lifetime
- 1991-03-01 AT AT93105233T patent/ATE166651T1/de not_active IP Right Cessation
- 1991-03-01 ZA ZA911533A patent/ZA911533B/xx unknown
- 1991-03-01 DK DK93105233T patent/DK0552817T3/da active
- 1991-03-01 DE DE69126534T patent/DE69126534T2/de not_active Expired - Fee Related
- 1991-03-01 DE DE69129498T patent/DE69129498T2/de not_active Expired - Fee Related
- 1991-03-01 EP EP91301749A patent/EP0448243B1/de not_active Expired - Lifetime
- 1991-03-01 DK DK91301749.7T patent/DK0448243T3/da active
- 1991-03-01 DE DE69116403T patent/DE69116403T2/de not_active Expired - Fee Related
- 1991-03-01 DK DK93105234.4T patent/DK0552818T3/da active
- 1991-03-01 NZ NZ237276A patent/NZ237276A/xx unknown
- 1991-03-01 EP EP93105234A patent/EP0552818B1/de not_active Expired - Lifetime
- 1991-03-01 ES ES93105233T patent/ES2117678T3/es not_active Expired - Lifetime
1994
- 1994-07-11 US US08/273,240 patent/US5604182A/en not_active Expired - Fee Related
1996
- 1996-03-05 GR GR960400609T patent/GR3019205T3/el unknown
1997
- 1997-08-26 GR GR970402182T patent/GR3024542T3/el unknown
1998
- 1998-06-03 HK HK98104832A patent/HK1005731A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2037414A1 (en)	1991-09-02
HK1005725A1 (en)	1999-01-22
US5346918A (en)	1994-09-13
ES2117678T3 (es)	1998-08-16
EP0552817A3 (en)	1993-10-06
HK1010456A1 (en)	1999-06-17
DE69116403D1 (de)	1996-02-29
EP0552817B1 (de)	1998-05-27
EP0552818A2 (de)	1993-07-28
AU7202691A (en)	1991-09-05
AU634864B2 (en)	1993-03-04
DE69126534T2 (de)	1998-02-05
ZA911533B (en)	1991-12-24
ES2084767T3 (es)	1996-05-16
ES2104987T3 (es)	1997-10-16
HK1005731A1 (en)	1999-01-22
DE69116403T2 (de)	1996-09-19
EP0448243B1 (de)	1996-01-17
DE69126534D1 (de)	1997-07-17
DE69129498D1 (de)	1998-07-02
KR0168848B1 (ko)	1999-01-15
ATE166651T1 (de)	1998-06-15
DE69129498T2 (de)	1999-03-04
ATE133174T1 (de)	1996-02-15
US5604182A (en)	1997-02-18
KR910016757A (ko)	1991-11-05
EP0552818A3 (en)	1993-10-06
DK0448243T3 (da)	1996-05-20
NZ237276A (en)	1993-04-28
GR3019205T3 (en)	1996-06-30
JP2622197B2 (ja)	1997-06-18
JPH04211087A (ja)	1992-08-03
GR3024542T3 (en)	1997-12-31
EP0552817A2 (de)	1993-07-28
EP0552818B1 (de)	1997-06-11
DK0552817T3 (da)	1999-01-25
EP0448243A1 (de)	1991-09-25
DK0552818T3 (da)	1998-01-19

Legal Events

Date	Code	Title	Description
1997-12-15	UEP	Publication of translation of european patent specification
2002-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE133174T1 (de)	1996-02-15	Milbemycinderivate, ihre herstellung und ihr therapeutischer und agrochemischer gebrauch
AU2819992A (en)	1993-05-13	Hiv protease inhibitors useful for the treatment of aids
DE69115313D1 (de)	1996-01-25	3-Tetrazolylthiomethyl-Cephalosporin-Antibiotika
ES450391A1 (es)	1977-11-16	Un procedimiento para la preparacion de derivados del acido 2-(m-fenoxifenil)-propionico.
FR2375235A1 (fr)	1978-07-21	Nouveaux diazabicyclo(3,3,1)nonanes, leur procede de preparation et medicament les contenant
GB1445803A (en)	1976-08-11	Soluble salt of a cephalosporin
IT1048274B (it)	1980-11-20	Esteri di penicilline e di cefauosporine
FI97883B (fi)	1996-11-29	Menetelmä lääkeaineena käyttökelpoisen glyserolijohdannaisen valmistamiseksi
ES475659A1 (es)	1979-10-16	Un procedimiento para la preparacion de derivados de cefa- losporina.
IT1036078B (it)	1979-10-30	Composizione antibatterica per anima i
US3381001A (en)	1968-04-30	Synthetic penicillins
IE36346B1 (en)	1976-10-13	Antibacterial agents and a process for the preparation thereof
FR2191882A1 (en)	1974-02-08	Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids
FR2123545A1 (en)	1972-09-08	(2-hydroxy (or alkoxy)imino)acylamido penicillanic and - cephalosporanic acids - useful as antibiotics and intermediates
FR2205334A1 (en)	1974-05-31	2-Aryl-phthalazine-1-acetic acid derivs - diuretics and saluretics, prepd. from 2-naphthol-1-sulphonic acid
ES420660A1 (es)	1976-04-16	Un metodo para la produccion de un compuesto de penicilina.
FR2194424A1 (en)	1974-03-01	Trialkoxybenzoylpeptide derivs - for treatment of cardiac disorders
FR2257292A2 (en)	1975-08-08	Piperazine derivs as antibacterial agents - esp. 7-piperazinyl-1-vinyl-1,8-naphthyridine or-quinoline-4-oxo-3-carboxylic acids
FR2428639A1 (fr)	1980-01-11	Nouvelles thenylamines, leur proecede de preparation et leur application en therapeutique
NL7413717A (en)	1975-04-22	Heterocyclic N-acyl derivs of amoxicillin and epicillin - broad-spectrum antibacterials esp. active against Pseudomonas spp.
NL7510483A (en)	1977-03-08	Alpha-ureido-thienylacetamido-cephalosporanic acids - with broad-spectrum antibacterial activity for oral or parenteral admin., for disinfection and as additives for animal feeds
CH519516A (de)	1972-02-29	Verfahren zur Herstellung neuer O-Desacetyl-7-N-acylamino-cephalosporansäurederivaten
FR2208654A2 (en)	1974-06-28	Heterocyclic esters of 5,5-dialkyl-8-substd 1,2,3,4-tetrahydro - -5h-(1)-benzopyrano(3,4-d)-pyridin-10-ols - with analgesic and mild
ES8503687A1 (es)	1985-03-16	Un procedimiento para preparar compuestos de cefem.
GB1283099A (en)	1972-07-26	Penicillin derivatives