ES2104987T3 - Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica. - Google Patents

Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.

Info

Publication number
ES2104987T3
ES2104987T3 ES93105234T ES93105234T ES2104987T3 ES 2104987 T3 ES2104987 T3 ES 2104987T3 ES 93105234 T ES93105234 T ES 93105234T ES 93105234 T ES93105234 T ES 93105234T ES 2104987 T3 ES2104987 T3 ES 2104987T3
Authority
ES
Spain
Prior art keywords
alkyl
nnhr9c
hydrogen
nitro
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93105234T
Other languages
English (en)
Inventor
Yasuhiro Morisawa
Akio Saito
Toshimitsu Toyama
Susumu Kaneko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2104987T3 publication Critical patent/ES2104987T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I): EN QUE: R1 ES UNA VARIEDAD DE GRUPOS ORGANICOS; R2 ES HIDROGENO, HALOGENO, CIANO, NITRO, ALQUILO OPCIONALMENTE SUSTITUIDO, ALCOXI, ALCOXIALCOXI O UN GRUPO DE LA FORMULA: -(CH2)NNHR9 -(CH2)NNHR9COR6 -(CH2)NNHR9COCOR6 -(CH2)NNHR9COCOOR7 -(CH2)NNHR9CHR6NHCOR6 -(CH2)NNHR9CHR6NHCONHR6 -(CH2)NNHR9CHR6NHCOOR7 -(CH2)NNHR9C(=Y)YR6 -(CH2)NNHR9C(=Y)NR6R6 -(CH2)NNHR9C(=Y)NR6NR6R6 -(CH2)NNHR9C(=Y)NR6NHZ -(CH2)NNHR9C(=NR10)NHR10 -(CH2)NNHR9C(=NR10)R6 O -(CH2)NNHR9SOMR6 (EN QUE M ES 1 O 2; N ES 0, 1 O 2; R6 ES UNA VARIEDAD DE GRUPOS ORGANCIOS; R7 ES ALQUILO, CICLOALQUILO O ARALQUILO; R9 ES HIDROGENO O ALQUILO; R10 ES CUALQUIERA DE ENTRE R6, O CIANO, NITRO, -COOR7 O -COR6; Y ES OXIGENO O AZUFRE; Z ES -COOR7, -COR6 O -SO2R6); Q ES METILENO, ETILENO O -OCH2; P ES METILENO, ETILENO, OXIGENO O UN ENLACE SENCILLO; V Y W REPRESENTAN CADA UNO METILENO, CARBONILO O TIOCARBONILO; R3 Y R4 SON HIDROGENO, ALQUILO O ALCOXI; R11 ES ALQUILO, ALCOXI, ALQUILTIO, ALCANOILOXI, ALCOXICARBONILO, HALOGENO, CIANO, NITRO, AMINO, MONO INO, CARBAMILO, MONO12 ES HIDROGENO O ALQUILO; R13 ES ALQUILO; R5 ES METILO, ETILO, ISOPROPILO O SEC-BUTILO; Y X ES HIDROXI, ALCANOILOXI O HIDROXIIMINO] Y LAS SALES Y ESTERES DE LOS MISMOS QUE TIENE ACTIVIDADES ANTELMINTICAS, ACARICIDAS E INSECTICIDAS VALIOSAS. TAMBIEN SE PRESENTAN LOS METODOS PARA LA PREPARACION DE LOS COMPUESTOS.
ES93105234T 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica. Expired - Lifetime ES2104987T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5076090 1990-03-01

Publications (1)

Publication Number Publication Date
ES2104987T3 true ES2104987T3 (es) 1997-10-16

Family

ID=12867790

Family Applications (3)

Application Number Title Priority Date Filing Date
ES93105234T Expired - Lifetime ES2104987T3 (es) 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.
ES93105233T Expired - Lifetime ES2117678T3 (es) 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.
ES91301749T Expired - Lifetime ES2084767T3 (es) 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES93105233T Expired - Lifetime ES2117678T3 (es) 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.
ES91301749T Expired - Lifetime ES2084767T3 (es) 1990-03-01 1991-03-01 Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.

Country Status (14)

Country Link
US (2) US5346918A (es)
EP (3) EP0448243B1 (es)
JP (1) JP2622197B2 (es)
KR (1) KR0168848B1 (es)
AT (3) ATE166651T1 (es)
AU (1) AU634864B2 (es)
CA (1) CA2037414A1 (es)
DE (3) DE69126534T2 (es)
DK (3) DK0552817T3 (es)
ES (3) ES2104987T3 (es)
GR (2) GR3019205T3 (es)
HK (3) HK1005725A1 (es)
NZ (1) NZ237276A (es)
ZA (1) ZA911533B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202452B (es) * 1989-12-01 1993-03-21 Ciba Geigy Ag
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
KR0171426B1 (ko) * 1991-12-18 1999-02-01 가와무라 요시부미 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도
AU666750B2 (en) * 1992-09-01 1996-02-22 Novartis Animal Health K.K. Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US5614470A (en) * 1994-04-01 1997-03-25 Sankyo Company, Limited 13-substituted milbemycin derivatives, their preparation and their use
AU3935495A (en) * 1994-11-24 1996-06-17 Sankyo Company Limited 13-etherified milbemycin derivative with insecticidal activity
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
EP3700334B1 (en) * 2017-10-27 2026-04-08 Immunebridge Inc. Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene
CN111217828B (zh) * 2018-11-26 2022-11-25 浙江海正药业股份有限公司 一种乐平霉素的制备方法及其中间体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4315023A (en) * 1979-09-06 1982-02-09 Westwood Pharmaceuticals, Inc. 1-Phenethylimidazole derivatives
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
JPS57120589A (en) * 1981-01-20 1982-07-27 Sankyo Co Ltd 5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide
JPS57190589A (en) * 1981-05-19 1982-11-24 Brother Ind Ltd Sound displayable sewing machine
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS5916894A (ja) * 1982-07-21 1984-01-28 Sankyo Co Ltd ミルベマイシンｄの５−アシルオキシ誘導体
JPS5920285A (ja) * 1982-07-23 1984-02-01 Sankyo Co Ltd ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
US4646541A (en) * 1984-11-13 1987-03-03 Columbia Gas System Service Corporation Absorption refrigeration and heat pump system
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
CH669382A5 (en) * 1986-05-21 1989-03-15 Ciba Geigy Ag 13-0-substd. milbemycin derivs. - with insecticidal, acaricidal, nematocidal and anthelmintic activity, prepd. by etherification of 13-0 unsubstituted cpds
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
KR0171426B1 (ko) * 1991-12-18 1999-02-01 가와무라 요시부미 13-(치환 티오) 아세톡시밀베마이신 유도체, 그의 제조방법 및 농화학적 용도

Also Published As

Publication number Publication date
ATE154357T1 (de) 1997-06-15
DE69129498T2 (de) 1999-03-04
EP0552817A3 (en) 1993-10-06
DE69116403T2 (de) 1996-09-19
GR3019205T3 (en) 1996-06-30
JP2622197B2 (ja) 1997-06-18
EP0552818A3 (en) 1993-10-06
ATE166651T1 (de) 1998-06-15
DK0448243T3 (da) 1996-05-20
HK1005725A1 (en) 1999-01-22
KR910016757A (ko) 1991-11-05
ZA911533B (en) 1991-12-24
AU7202691A (en) 1991-09-05
DE69116403D1 (de) 1996-02-29
EP0552817A2 (en) 1993-07-28
ATE133174T1 (de) 1996-02-15
US5604182A (en) 1997-02-18
CA2037414A1 (en) 1991-09-02
EP0552818A2 (en) 1993-07-28
DE69126534T2 (de) 1998-02-05
KR0168848B1 (ko) 1999-01-15
EP0552817B1 (en) 1998-05-27
JPH04211087A (ja) 1992-08-03
HK1005731A1 (en) 1999-01-22
EP0552818B1 (en) 1997-06-11
NZ237276A (en) 1993-04-28
US5346918A (en) 1994-09-13
DE69129498D1 (de) 1998-07-02
DK0552818T3 (da) 1998-01-19
EP0448243B1 (en) 1996-01-17
DE69126534D1 (de) 1997-07-17
HK1010456A1 (en) 1999-06-17
ES2084767T3 (es) 1996-05-16
EP0448243A1 (en) 1991-09-25
GR3024542T3 (en) 1997-12-31
DK0552817T3 (da) 1999-01-25
AU634864B2 (en) 1993-03-04
ES2117678T3 (es) 1998-08-16

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