ATE154363T1 - Synthetische polypeptide als inhibitoren von hiv- 1 - Google Patents

Synthetische polypeptide als inhibitoren von hiv- 1

Info

Publication number
ATE154363T1
ATE154363T1 AT93200863T AT93200863T ATE154363T1 AT E154363 T1 ATE154363 T1 AT E154363T1 AT 93200863 T AT93200863 T AT 93200863T AT 93200863 T AT93200863 T AT 93200863T AT E154363 T1 ATE154363 T1 AT E154363T1
Authority
AT
Austria
Prior art keywords
hiv
polypeptides
inhibitors
infections
synthetic polypeptides
Prior art date
Application number
AT93200863T
Other languages
English (en)
Inventor
Shibo Jiang
Kang Lin
A Robert Neurath
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Application granted granted Critical
Publication of ATE154363T1 publication Critical patent/ATE154363T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93200863T 1992-03-26 1993-03-25 Synthetische polypeptide als inhibitoren von hiv- 1 ATE154363T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/859,923 US5444044A (en) 1992-03-26 1992-03-26 Synthetic polypeptides as inhibitors of HIV-1

Publications (1)

Publication Number Publication Date
ATE154363T1 true ATE154363T1 (de) 1997-06-15

Family

ID=25332065

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93200863T ATE154363T1 (de) 1992-03-26 1993-03-25 Synthetische polypeptide als inhibitoren von hiv- 1

Country Status (9)

Country Link
US (2) US5444044A (de)
EP (1) EP0565164B1 (de)
JP (1) JP3587538B2 (de)
KR (1) KR100269818B1 (de)
AT (1) ATE154363T1 (de)
AU (1) AU667078B2 (de)
CA (1) CA2092519C (de)
DE (1) DE69311427T2 (de)
ES (1) ES2107609T3 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
DE69326069T2 (de) * 1992-07-20 2000-03-23 Duke University, Durham Zusammensetzungen die die hiv replikation inhibieren
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US20070202127A1 (en) * 1993-06-07 2007-08-30 Duke University Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
US6818740B1 (en) 1997-04-17 2004-11-16 Whitehead Institute For Biomedical Research Inhibitors of HIV membrane fusion
US6841657B2 (en) 1997-04-17 2005-01-11 Whitehead Institute For Biomedical Research Inhibitors of HIV membrane fusion
US6150088A (en) 1997-04-17 2000-11-21 Whitehead Institute For Biomedical Research Core structure of gp41 from the HIV envelope glycoprotein
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
WO1999048513A1 (en) * 1998-03-23 1999-09-30 Trimeris, Inc. Methods and compositions for peptide synthesis
US6747126B1 (en) 1998-07-30 2004-06-08 Whitehead Institute For Biomedical Research Peptide inhibitors of HIV entry
US7960504B2 (en) * 1998-07-30 2011-06-14 Whitehead Institute For Biomedical Research Inhibitors of HIV membrane fusion
US6596497B1 (en) 1999-03-17 2003-07-22 New York Blood Center, Inc. Screening of antiviral compounds targeted to the HIV-1 gp41 core structure
ES2296665T3 (es) * 1999-12-16 2008-05-01 Whitehead Institute For Biomedical Research Proteina cinco-helice.
US20030082525A1 (en) * 1999-12-16 2003-05-01 Whitehead Institute For Biomedical Research Five-Helix protein
NZ520754A (en) 2000-02-10 2004-02-27 Panacos Pharmaceuticals Inc Identifying compounds that disrupt formation of critical gp41 six-helix bundle and conformations necessary for HIV entry thereby blocking virus entry to the cell
CA2403718A1 (en) * 2000-03-17 2001-09-27 Panacos Pharmaceuticals, Inc. A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins
US20030125515A1 (en) * 2001-07-11 2003-07-03 Genfa Zhou End-locked five-helix protein
AU2002351176A1 (en) * 2001-11-29 2003-06-17 Mymetics, Corp. Peptides and use thereof in therapeutic agents against hiv infection
AU2003277378A1 (en) * 2002-10-16 2004-05-04 Panacos Pharmaceuticals, Inc. Method for detecting viral inactivating agents
WO2005060350A2 (en) * 2003-12-22 2005-07-07 Yeda Research & Development Co. Ltd. Diastereomeric peptides useful as inhibitors of membrane protein assembly
US7811577B2 (en) * 2004-06-01 2010-10-12 Merck Sharp & Dohme Corp. Covalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity
ATE516048T1 (de) * 2004-06-01 2011-07-15 Merck Sharp & Dohme Mit hiv gp41 in wechselwirkung stehende menschliche antikörper
CN101115498A (zh) * 2005-01-24 2008-01-30 耶达研究与发展有限公司 用于免疫调节的HIV-1 gp41融合肽
JP2008534640A (ja) * 2005-04-05 2008-08-28 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー タンパク質の機能部位またはエピトープの遮蔽方法
JP4831410B2 (ja) * 2006-02-28 2011-12-07 東亞合成株式会社 抗ウイルス性ペプチドおよび抗ウイルス剤
JP4788958B2 (ja) * 2006-02-28 2011-10-05 東亞合成株式会社 抗ウイルス性ペプチドおよびその利用
AU2009260479A1 (en) * 2008-05-28 2009-12-23 New York Blood Center Bifunctional molecules for inhibiting HIV entry
CN102307588A (zh) * 2009-02-09 2012-01-04 纽约血库公司 用于治疗或预防hiv感染的三聚体hiv融合抑制剂
WO2011140092A1 (en) 2010-05-03 2011-11-10 New York Blood Center, Inc. Bifunctional molecules for inactivating hiv and blocking hiv
EP2447277A1 (de) 2010-10-28 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Impfstoffzusammensetzungen auf Basis von modifizierten gp41-Immunogenen
CN113498417B (zh) 2020-02-05 2022-11-01 山西锦波生物医药股份有限公司 多肽、其制备方法和用途
CN119613503B (zh) * 2024-07-22 2026-02-06 山西锦波生物医药股份有限公司 可抑制类mers冠状病毒感染的多肽及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586575B1 (fr) * 1985-08-30 1991-09-06 Lepage Pierre Alain Programmateur d'efforts pour l'entrainement du cycliste
EP0269712A4 (de) * 1986-06-12 1990-06-26 Biogen Nv An der pathogenese einer hiv-infektion beteiligte peptide.
EP0330359A3 (de) * 1988-02-25 1991-06-05 Bio-Rad Laboratories, Inc. Zusammensetzung, verwendbar zur Diagnose und Behandlung von HIV-I-Infektion
AU608413B2 (en) * 1988-03-30 1991-03-28 Abbott Laboratories Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1

Also Published As

Publication number Publication date
EP0565164B1 (de) 1997-06-11
ES2107609T3 (es) 1997-12-01
CA2092519A1 (en) 1993-09-27
JP3587538B2 (ja) 2004-11-10
CA2092519C (en) 2003-03-18
EP0565164A1 (de) 1993-10-13
DE69311427T2 (de) 1998-02-12
KR100269818B1 (ko) 2000-10-16
US5444044A (en) 1995-08-22
DE69311427D1 (de) 1997-07-17
JPH06340698A (ja) 1994-12-13
US5840843A (en) 1998-11-24
AU3537293A (en) 1993-09-30
KR930019695A (ko) 1993-10-18
AU667078B2 (en) 1996-03-07

Similar Documents

Publication Publication Date Title
ATE154363T1 (de) Synthetische polypeptide als inhibitoren von hiv- 1
DE69432475D1 (de) Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis
ES2075040T3 (es) 2',3'-dideoxi-2',2'-difluoronucleosidos.
TW262468B (de)
DK0590006T3 (da) Syntetiske pulmonære surfaktantpeptider
ATE174382T1 (de) Retrovirus aus der hiv-gruppe und dessen verwendung
DE59007550D1 (de) Verfahren zur Stabilisierung einer festen pharmazeutischen Zubereitungsform von cyclischen Aminosäuren.
EA199700221A1 (ru) Замещенный аминокислотой гидроксиэтиламиносульфонамид в качестве ингибиторов ретровирусной протеазы
ATE286978T1 (de) Rekombinante hiv-2 antigenen, abgeleitete aus synthetischen dns
DK0617968T3 (da) HIV-proteaseinhibitorer i farmaceutiske kombinationer til behandling af AIDS
MY135057A (en) Dolastatin 15 derivatives
ATE211384T1 (de) Verwendung von adenosinantagonisten zur vorbeugung und behandlung von pankreatitis und ulcera
NO921829L (no) Nytt polypeptid, samt anti-hiv-medikament fremstilt derav
ATE215952T1 (de) Hiv-proteaseinhibitoren
DK0604183T3 (da) HIV-protease-inhibitorer anvendelige i behandlingen af AIDS
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
DK0579363T3 (da) Behandling af tropisk spastisk parese med peptid T
EA199800661A1 (ru) Ингибиторы аспартильных протеаз
DK0394194T3 (da) Beskyttede aminosyrer og fremgangsmåde til fremstilling deraf
DK0789764T3 (da) Ny familie af proteaseinhibitorer og andre biologisk aktive substanser
WO1994004565A3 (en) Ipnv vaccine
RU95109909A (ru) Способ ингибирования ретровирусной инфекции, ингибитор протеазы, кодирующая его нуклеиновая кислота и способ рекомбинантного продуцирования серинового ингибитора
AU4426689A (en) Recombinant polypeptides of the hemorragic septicemy virus of fish
ATE100318T1 (de) Verwendung von chinolyl- und isochinolyloxazol-2- onen zur herstellung eines arzneimittels zur verhinderung der ansteckungsfaehigkeit von mit glykoproteinen umhuellten viren.
RU93046287A (ru) Аминодиольные ингибиторы протеза

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties