ATE290592T1 - Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis - Google Patents
Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitisInfo
- Publication number
- ATE290592T1 ATE290592T1 AT99116671T AT99116671T ATE290592T1 AT E290592 T1 ATE290592 T1 AT E290592T1 AT 99116671 T AT99116671 T AT 99116671T AT 99116671 T AT99116671 T AT 99116671T AT E290592 T1 ATE290592 T1 AT E290592T1
- Authority
- AT
- Austria
- Prior art keywords
- human
- hepatitis virus
- immunodominant epitopes
- cell immunodominant
- amino acids
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93402718 | 1993-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290592T1 true ATE290592T1 (de) | 2005-03-15 |
Family
ID=8214764
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94931000T ATE236981T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
| AT99116671T ATE290592T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
| AT99116672T ATE274578T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94931000T ATE236981T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99116672T ATE274578T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6555114B1 (de) |
| EP (4) | EP0992580B1 (de) |
| JP (2) | JPH09504534A (de) |
| AT (3) | ATE236981T1 (de) |
| AU (1) | AU698878B2 (de) |
| CA (1) | CA2175692A1 (de) |
| DE (3) | DE69432475T2 (de) |
| DK (2) | DK0992580T3 (de) |
| ES (2) | ES2239819T3 (de) |
| PT (2) | PT992580E (de) |
| WO (1) | WO1995012677A2 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026306A1 (en) | 1993-05-12 | 1994-11-24 | Chiron Corporation | Conserved motif of hepatitis c virus e2/ns1 region |
| US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| ATE236981T1 (de) * | 1993-11-04 | 2003-04-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| JPH10503473A (ja) * | 1994-04-08 | 1998-03-31 | アメリカ合衆国 | 細胞傷害性tリンパ球刺激およびhcv曝露診断用c型肝炎ウイルスコアペプチド |
| CA2305847A1 (en) | 1997-11-06 | 1999-05-20 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes |
| DK1071955T4 (da) | 1998-04-17 | 2009-06-15 | Innogenetics Nv | Forbedrede immundiagnostiske assays, som anvender reduktionsmidler |
| AU3714499A (en) * | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
| NZ508812A (en) * | 1998-06-12 | 2002-11-26 | Aventis Pasteur | Peptides for the prevention or treatment of HIV |
| AU765940B2 (en) * | 1998-06-24 | 2003-10-02 | Innogenetics N.V. | Particles of HCV envelope proteins: use for vaccination |
| US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| DE69935599T2 (de) | 1998-08-21 | 2007-11-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Modifizierte hcv peptid-impfstoffe |
| DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
| US6858590B2 (en) * | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| WO2002020035A1 (en) * | 2000-09-01 | 2002-03-14 | Epimmune Inc. | Hla binding peptides and their uses |
| GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
| US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
| US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
| US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| CN1636050A (zh) | 2001-04-24 | 2005-07-06 | 基因创新有限公司 | 核心糖基化hcv包膜蛋白 |
| FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
| FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
| US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
| JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
| GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
| US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| EP1461080A2 (de) * | 2001-12-18 | 2004-09-29 | Innogenetics N.V. | Gereinigte hepatitis c virus hüllproteine zur diagnostischen und therapeutischen verwendung |
| US7201904B2 (en) | 2002-05-16 | 2007-04-10 | The General Hospital Corporation | Epitopes of hepatitis C virus |
| US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| AU2003248818A1 (en) * | 2002-07-02 | 2004-01-23 | Novartis Vaccines And Diagnostics, Inc. | Hcv fusion proteins with modified ns3 domains |
| AU2003283365A1 (en) * | 2002-11-08 | 2004-06-07 | Innogenetics N.V. | HCV vaccine compositions comprising E1 and NS3 peptides |
| AU2003303889A1 (en) * | 2003-01-07 | 2004-08-30 | Biomerieux | Polypeptides f' of the hepatitis c virus, epitopes, and the diagnostic and therapeutic applications thereof |
| US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| WO2006004362A1 (en) * | 2004-07-03 | 2006-01-12 | Mogam Biotechnology Research Institute | Supertype epitopes, oligonucleotides coding the same which induce effective ctl response against hcv and the use thereof |
| US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
| CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
| PL1797112T3 (pl) * | 2004-09-29 | 2011-04-29 | The Administrators Of The Tulane Educational Fund | Inhibitory wirusa zapalenia wątroby typu C |
| EP2460533A3 (de) * | 2004-10-18 | 2014-01-08 | Globeimmune, Inc. | Therapeutikum auf Hefebasis gegen chronische Hepatitis-C-Infection |
| CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| CA2623329A1 (en) * | 2005-10-13 | 2007-04-19 | Virexx Medical Corp. | Chimeric antigen containing hepatitis c virus polypeptide and fc fragment for eliciting an immune response |
| AU2007261399A1 (en) * | 2006-06-20 | 2007-12-27 | Metaproteomics, Llc | Reduced isoalpha acid based protein kinase modulation cancer treatment |
| EP2040745B1 (de) * | 2006-06-28 | 2012-12-05 | Statens Serum Institut | Expansion des t-zell-repertoirs, um subdominante epitope durch impfung mit antigenen, die als proteinfragmente oder peptidcocktails abgegeben werden, aufzunehmen |
| US8071561B2 (en) * | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| US20090214593A1 (en) * | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
| ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
| WO2010033841A1 (en) | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| CN107375919B (zh) | 2009-03-27 | 2022-07-29 | 台湾地区“中央研究院” | 抗病毒免疫的方法和组合物 |
| WO2010112733A1 (fr) * | 2009-03-30 | 2010-10-07 | bioMérieux | Support solide de détection du vhc |
| JP5930967B2 (ja) * | 2010-09-08 | 2016-06-08 | 学校法人 埼玉医科大学 | C型肝炎ウイルスリポソームワクチン |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
| EP2646459B1 (de) | 2010-12-02 | 2020-01-08 | Bionor Immuno AS | Peptidgerüstentwurf |
| JP6294076B2 (ja) | 2011-01-06 | 2018-03-14 | ビオノール イミュノ エーエスBionor Immuno As | 多量体ペプチド |
| IN2014KN02769A (de) | 2012-06-06 | 2015-05-08 | Bionor Immuno As | |
| WO2014129412A1 (ja) * | 2013-02-19 | 2014-08-28 | 国立大学法人神戸大学 | 免疫原性ポリペプチド表層発現ビフィズス菌 |
| JP2016512241A (ja) | 2013-03-14 | 2016-04-25 | アボット・ラボラトリーズAbbott Laboratories | 改良された抗体検出のためのhcvns3組換え抗原およびこの突然変異体 |
| MX362075B (es) | 2013-03-14 | 2019-01-07 | Abbott Lab | Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo. |
| WO2014143343A1 (en) * | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
| JP6449272B2 (ja) * | 2013-07-08 | 2019-01-09 | ナンジン レジェンド バイオテック カンパニー,リミテッドNanjing Legend Biotech Co.,Ltd. | タンパク質の血清半減期を増加する組成物及び方法 |
| AU2017332854B2 (en) | 2016-09-21 | 2024-11-14 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
| EP3765075A4 (de) * | 2018-03-16 | 2021-12-08 | The Governors of the University of Alberta | Hepatitis-c-virus-peptidzusammensetzungen und verfahren zur verwendung davon |
| CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
| JP2022518488A (ja) * | 2019-01-25 | 2022-03-15 | センティ バイオサイエンシズ インコーポレイテッド | タンパク質機能を制御するための融合構築物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US6027729A (en) | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| AU7679491A (en) * | 1990-04-04 | 1991-10-30 | Protos, Inc. | Hepatitis c virus protease inhibitors |
| US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
| KR0181517B1 (ko) | 1990-07-09 | 1999-04-01 | 나까하라 노부유끼 | 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도 |
| CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
| CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
| CA2055149A1 (en) * | 1990-11-08 | 1992-05-09 | Hiroaki Okamoto | Non-a, non-b hepatitis virus related antigen, antibody, detection systems, polynucleotides and polypeptides |
| EP0544861A4 (en) | 1991-06-13 | 1997-06-04 | Baxter Diagnostics Inc | Immunoassay for non-a non-b hepatitis |
| ES2188583T3 (es) * | 1991-06-24 | 2003-07-01 | Chiron Corp | Polipeptidos para el virus de la hepatitis c (hcv). |
| DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
| US5428145A (en) | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| AU2513592A (en) * | 1991-08-21 | 1993-03-16 | Abbott Laboratories | Hepatitis c assay utilizing recombinant antigens to ns1 |
| RU2212899C2 (ru) | 1991-09-13 | 2003-09-27 | Чирон Корпорейшн | Hcv иммунореактивные полипептидные композиции |
| AU2679492A (en) * | 1991-09-16 | 1993-04-27 | Abbott Laboratories | Hepatitis c assay |
| DK0625204T3 (da) * | 1992-02-04 | 2002-07-15 | Chiron Corp | Terapeutiske midler mod hepatitis |
| SG77551A1 (en) * | 1992-03-06 | 2005-04-28 | Innogenetics Nv | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing |
| EP0728764A4 (de) | 1993-10-19 | 1999-01-20 | Ajinomoto Kk | Peptide das eine immunantwort gegen hiv unduziert und arzneimittel die esenthaelt zur vorbeugung oder behandlung von aids |
| ATE236981T1 (de) * | 1993-11-04 | 2003-04-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 EP EP99116671A patent/EP0992580B1/de not_active Revoked
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 EP EP99116672A patent/EP0992581B2/de not_active Expired - Lifetime
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/en not_active Ceased
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 EP EP94931000A patent/EP0725824B1/de not_active Revoked
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 CA CA002175692A patent/CA2175692A1/en not_active Abandoned
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
- 1994-10-28 EP EP99116673A patent/EP0979867A3/de not_active Withdrawn
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
-
1997
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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